356 research outputs found
Supplemental Material, appendix - Generalized Inflated Discrete Models: A Strategy to Work with Multimodal Discrete Distributions
No full textSupplemental Material, appendix for Generalized Inflated Discrete Models: A Strategy to Work with Multimodal Discrete Distributions by Tianji Cai, Yiwei Xia, and Yisu Zhou in Sociological Methods & Research</p
sj-docx-1-tan-10.1177_17562864241227304 – Supplemental material for Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study
No full textSupplemental material, sj-docx-1-tan-10.1177_17562864241227304 for Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study by Weiyi Zhong, Yiwei Xia, Yunqing Ying, Yi Wang, Lumeng Yang, Xiaoniu Liang, Qianhua Zhao, Jianjun Wu, Zonghui Liang, Xiaoxiao Wang, Xin Cheng, Ding Ding and Qiang Dong in Therapeutic Advances in Neurological Disorders</p
sj-docx-2-tan-10.1177_17562864241227304 – Supplemental material for Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study
No full textSupplemental material, sj-docx-2-tan-10.1177_17562864241227304 for Cerebral pulsatility in relation with various imaging markers of cerebral small vessel disease: a longitudinal community-based study by Weiyi Zhong, Yiwei Xia, Yunqing Ying, Yi Wang, Lumeng Yang, Xiaoniu Liang, Qianhua Zhao, Jianjun Wu, Zonghui Liang, Xiaoxiao Wang, Xin Cheng, Ding Ding and Qiang Dong in Therapeutic Advances in Neurological Disorders</p
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Dialoguing with the World: Xue Yiwei and His Traveling with Marco Polo
No full textThis essay introduces the author Xue Yiwei and his Traveling with Marco Polo, a creative collection that dialogues with Invisible Cities by the postmodern Italian writer Italo Calvino. While Calvino imagines a young Marco Polo describing the fantastic sights of fifty-five cities to an aging Kublai Khan, Xue Yiwei joins the conversation and provides a meticulous explication of each one of Calvino’s cities. Furthermore, Traveling with Marco Polo expands the imaginary cityscapes to include oblique commentaries on the past, present, and future of China as well as the profound meditation on the city as a microcosm of our world. The result is a daring literary experiment that is representative of Xue’s oeuvre overall: at once giving a powerful literary representation of modern Chinese history while engaging in dialogue with writers from all over the world
gidm: A command for generalized inflated discrete models
No full textIn this article, we describe the gidm command for fitting generalized inflated discrete models that deal with multiple inflated values in a distribution. Based on the work of Cai, Xia, and Zhou (Forthcoming, Sociological Methods & Research: Generalized inflated discrete models: A strategy to work with multimodal discrete distributions), generalized inflated discrete models are fit via maximum likelihood estimation. Specifically, the gidm command fits Poisson, negative binomial, multinomial, and ordered outcomes with more than one inflated value. We illustrate this command through examples for count and categorical outcomes
In vitro tendon tissue engineering
No full textTendon, ligament, and joint capsular injuries represent 45% of the 32 million musculoskeletal injuries each year in the United States. Tendon injuries are especially common, requiring surgical repair for the shoulder’s rotator cuff tendons (51,000 per year), the Achilles tendon (44,000 per year), and the patellar tendon (42,000 per year). Tissue engineering provides an alternative in the treatment of tendon lesions through replacement of an injured tendon segment. The purpose of this study was to develop a tendon construct in vitro for clinical reconstructive surgery. Human tenocytes were isolated from hamstring tendons of patients who had undergone anterior cruciate ligament (ACL) surgeries. These tenocytes were cultured with culture media (α-MEM) supplemented with various concentrations of foetal bovine serum (FBS) (0%, 1%, 5% and 10%) and in the presence of different growth factors such as PDGFBB (0, 5, 10 and 50ng/ml), basic FGF (0, 5, 10 and 50ng/ml), IGF-1 (0, 10 and 50ng/ml) and TGFβ-3 (0, 1 and 10ng/ml). Fractional factorial design was utilized to select the combinations of growth factors that supported the following criteria: (1) the maximal cell proliferation with a minimum differentiation of the tenocytes in the presence of the least concentration of FBS possible and (2) maintaining cell survival and promoting tenocyte differentiation in FBS free culture media. The results have shown that: (i) The tenocyte cell number when cultured for 14 days in media supplemented with 1% FBS, 50ng/ml PDGFBB and 50ng/ml bFGF matched that of the positive control (10% FBS-treated cells). Not only was the collagen synthesis significantly reduced in these growth factor-treated cultures compared to positive control tenocytes, but also a significant inhibition of the mRNA expression of various tenocyte differentiation markers (Scleraxis, Tenomodulin, Collagen type I and Decorin) was evident. IGF-1 did not promote significant cell proliferation under low serum conditions but did induce tenocyte differentiation in vitro. Examination of the cell morphology confirmed that tenocytes were capable of less differentiation when cultured with 1% FBS, 50ng/ml PDGFBB and 50ng/ml bFGF, this culture condition was termed “the expansion phase”; (ii) The cell survival was maintained for up to 14 days in serum free culture media supplemented with 50ng/ml IGF-1 and 10ng/ml TGFβ-3 whilst cell differentiation was enhanced and evident by the increase in collagen synthesis and cell morphology. Furthermore, mRNA expression of the aforementioned cell differentiation markers were also significantly increased, this culture condition was termed “the differentiation phase”; (iii) By combining the culture condition optimized for the expansion and differentiation phase sequentially, it was possible to maintain a long term 2-D tenocyte culture in vitro for up to 28 days. In these cultures, the presence of dense collagen formation was clearly evident whereas in positive control group (10% FBS group) such observation was not noted even after prolonged culturing period of up to 45 days. These results suggested that the sequential treatment of tenocytes with growth factors identified for the expansion and differentiation phases was significantly more superior than the standard 10% FBS treatment; (iv) By combining the expansion and differentiation phases optimized for the 2-D cultures, it was possible to maintain human tenocytes in a 3-D scaffold (Bombix silk) for up to 28 days. The tendon like constructs that were formed, macroscopically and microscopically resembled the human hamstring tendon. This observation was confirmed by using H&E; staining, scanning electron microscopy and by detecting collagen type I immunohistochemically; (v) It was possible to further validate these findings using in vivo animal models. This was undertaken by implanting the tenocytes cultured sequentially in the defined culture media described above, into the quadriceps of Balb/c nude male mice for up to 30 days. The nature and specificity of the tendon like structure that was formed after this implantation was investigated by H&E; staining and immunohistochemistry. It was revealed that the culture conditions that were optimized during the expansion and differentiation phases were suitable for generating a human tendon reconstruct; a finding which is of significance due to its potential for tendon reconstructive surgery
New Insights into Materialism and Conspicuous Consumption in China
No full textThis paper provides insights based on recent literature and findings that relate to materialism and conspicuous consumption among Chinese consumers. There is a specific focus on gender related issues and implications on consumer well-being. Our work is intended to assist in both conceptual and hypothesis development for other interested scholars.Peer reviewe
Exploring Causal Factors Influencing Enterprise Architecture Failure
No full textOrganizations have adopted Enterprise Architecture (EA) for managing their IT-landscape and ensuring coherence among projects and activities. There is much work about approaches, methods, and tools for EA based on the assumption that their use will create business value. However, the failure of many EA efforts results in the need to investigate the factors influencing EA failure in practice. In this paper, we used a literature review to identify ten EA failure factors. Then we employed the grey-DEMATEL method to explore and analyze the influence of the ten EA failure factors based on the input of five EA experts. The result shows that failure factors are not in isolation, and they can be divided into either causal or effect factors. The factors do not have equal importance but differ in the levels of influence. For the causal factors, the ranking from most to least important is the inability to handle complexity, lack of proven EA methodology, lack of EA knowledge, lack of communication, and lack of tools. For the effect factors, the factors are a lack of support, too high effort, lack of motivation, parallel processes, and unused artifacts. We recommend practitioners to pay more attention to the five causal factors in their EA efforts. Further research is needed to generalize the findings, to understand the dependencies among factors, and to take into account situational dependency of EA failure.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Information and Communication Technolog
Site-Specific Ground Motions for Dynamic Analyses in Regions of Lower Seismicity
No full text© 2022 Yiwei HUSite-specific dynamic analyses of structures have many advantages over traditional code spectrum procedures in regions of lower seismicity. The prime reason is that the site-specific response spectra and accelerograms are more realistic representations of earthquake actions for a structure located on a unique construction site. Developing site-specific ground motions requires a comprehensive understanding of regional seismic hazard analyses, soil condition analyses and site response analyses. Guidelines or facilities for performing site-specific dynamic analyses in accordance with the design code are unavailable to engineering practitioners in Australia.
The primary objective of this thesis is to develop a computationally effective method to generate response spectra and accelerograms for site-specific dynamic analysis in intraplate regions of lower seismicity, with a focus on the Southeastern Australia (SEA) region. Based on the proposed method, this thesis provides suites of ground motions in compliance with the Australian standard for direct engineering applications.
The conditional mean spectrum (CMS) methodology was first reviewed and its challenges for application in intraplate regions were overcome by employing a diversity of ground motion prediction expressions (GMPEs) and the uniform seismicity model. Three different schemes using a weighted averaging of candidate GMPEs were adopted, and a comparison of predictions demonstrated only minor differences confirming the robustness of the modelling.
The constructed CMS were targeted for sourcing ground motions to define seismic hazard at the bedrock level. The bedrock motions were amplified through soil column models to simulate site amplification effects. Subsoil information retrieved from multiple borehole records from the same site was sampled to construct soil column models to achieve conservative estimations of soil amplification ratio at the fundamental period of vibration of the structure to account for resonance. The sampling process involves closed-form expressions for determining the shear strain profile in a soil column considering degradation in the shear modulus of the soil in seismic conditions.
The applications of resultant site-specific response spectra and accelerograms, following a ground motion selection scheme proposed by the author, were demonstrated with nonlinear time history analysis for structural design and multiple stripe analysis for risk assessment.
This thesis is concluded with three outcomes: (1) a ground motion database for site-specific seismic design based on twenty sites that typify subsoil profiles in SEA, (2) an online program at https://quakeadvice.org/ for generating ground motions with user-defined borehole information, and (3) suites of ground motions for risk assessment of structures following the multiple stripe analysis method
UGent-T2K at the 2nd DialDoc Shared Task: A Retrieval-Focused Dialog System Grounded in Multiple Documents
No full textThis research received funding from the Flemish Government under the "Onderzoeksprogramma Artificiele Intelligentie (AI) Vlaanderen" programme. The first author was supported by China Scholarship Council (201806020194). We thank the anonymous reviewers whose comments helped to improve our work
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