244,341 research outputs found
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
Differential Equations of Some Classes of Special Functions via the Factorization Method
No full textLet {P n(x)} n=0∞ be a sequence of polynomials of degree n. We define two sequences of differential operators Φ n and ψ n satisfying the following properties Φ n(P n(x))=P n-1(x), Ψ n(Pn(x)) = P n+1(x). By constructing these two operators for some classes of special functions, we determine their differential equations via the factorization method introduced in [3]. We illustrate our method by including classical orthogonal polynomials, d-orthogonal polynomials, confluent hypergeometric functions and hypergeometric functions as the applications. Copyright 2004 Eudoxus Press, LLC
TOPS Imaging with TerraSAR-X: Mode Design and Performance Analysis
No full textThis paper reports about the performed investigations for the implementation of the wide swath TOPS imaging mode with TerraSAR-X. The TOPS mode overcomes the limitations imposed by the ScanSAR mode by steering the antenna along-track during the acquisition of a burst. In this way, a uniform signal to noise ratio (SNR) is achieved, and consequently, scalloping and an azimuth-dependent distributed target ambiguity ratio (DTAR) are avoided. However, the use of electronically steered antennas leads to a quantization of the steering law and a non-ideal pattern for squinted angles (grating lobes and main lobe reduction). The former provokes spurious peaks, while the latter introduces a slight scalloping and DTAR deterioration. These effects are analyzed and quantified for TerraSAR-X and a TOPS system design approach is presented. Next, the requirements concerning interferometry are investigated. Finally, several results are shown with TerraSAR-X data, including a comparison between the TOPS and ScanSAR modes and the reporting of first TOPS interferometric results
Reynolds numbers near the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the mean-flow Reynolds number ReU and the rms fluctuation Reynolds number ReV in turbulent Rayleigh-Bénard convection as a function of the Rayleigh number Ra for 4 x 1011 < Ra < 2 1014 and Pr ' 0:8. Both can be described by the same power law with an effective exponent = 0:44, in agreement with predictions for ReU but in disagreement with predictions for ReV
Preface
No full textThe MDEF Workshop has been held at the University of Urbino since 2000. The 2014 Workshop is particularly dedicated to Carl Chiarella for his 70th birthday. As the second home (along with the University of Bielefeld, another second home), Carl visited Urbino in 1998 for the first time and the visit has become an almost annual event since then. In order to commemorate the occasion, a number of Carl’s colleagues from around the world gladly agreed to contribute chapters to a special book dedicated to this event. The book is the outcome of this process. It contains the latest developments in nonlinear economic dynamics, financial market modeling, and quantitative finance, the three most active research areas Carl has been involved in
Replication Data for Xiaobin He: Between Legitimacy and Socioemotional Wealth: Family Ownership and the Party Branches Building of Chinese Private Enterprises
No full textThis file contains datasets and Stata codes used for the paper: He, X., & Liu, J. 2022. Between Legitimacy and Socioemotional Wealth: Family Ownership and the Party Branches Building of Chinese Private Enterprises. Management and Organization Review.(forthcoming)
Introduction
No full textThis book reflects the state of the art on nonlinear economic dynamics, financial market modelling and quantitative finance. It contains eighteen papers with topics ranging from disequilibrium macroeconomics, monetary dynamics, monopoly, financial market and limit order market models with boundedly rational heterogeneous agents to estimation, time series modelling and empirical analysis, and from risk management of interest-rate products, futures price volatility and American option pricing with stochastic volatility to evaluation of risk and derivatives of electricity market. The book illustrates some of the most recent research tools in these areas and will be of interest to economists working in economic dynamics and financial market modelling, to mathematicians who are interested in applying complexity theory to economics and finance, and to market practitioners and researchers in quantitative finance interested in limit order, futures and electricity market modelling, derivative pricing and risk management
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