170,397 research outputs found
The Cimicifuga racemosa special extract BNO 1055 prevents hot flashes in ovariectomized rats
No full textHot flashes are a disorder of thermoregulation due to the lack of estrogens and are the most common and characteristic climacteric complaint. Hormone replacement therapy is the gold standard treatment but now its use is limited due to several side effects. Need therefore arises to search for non-estrogenic alternatives. It is well established that extracts of Cimicifuga racemosa (CR) ease climacteric complaints but solid animal experimental data supporting such effects are not available. The availability of sensitive transponders which record subcutaneous temperature continuously enables nowadays experiments in rats to establish whether they have hot flashes following ovariectomy (Seidlova-Wuttke et al. 2003) and if so, whether they can be influenced by the extract of CR BNO 1055. Intact Sprague-Dawley rats (n = 16) were acclimatized and their subcutaneous body temperature was measured in 5 min intervals and mean values from 3 h recordings were calculated. Thereafter, the rats were ovx and fed either with soy free (sf) or CR BNO 1055 (25 mg/animal/day) food. Temperature was recorded again after acute and sub-acute application of CR. In individual intact animals temperature was stable over the 3 h recording period. Following ovx temperature pulses appeared with peaks occurring every 20-40 min. These fluctuations were not seen in CR BNO 1055 treated animals resulting in significantly higher mean temperatures in ovx in comparison to intact or ovx CR BNO treated rats. This reduction of hot flashes by BNO 1055 outlasted the experimental period of 3 weeks. These results suggest that the ovx rats and the new temperature-sensitive device may be useful for the study of hot flashes. Furthermore the results prove that the CR BNO 1055 exerts hot flash reducing effects. (C) 2010 Elsevier GmbH. All rights reserved
The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers
No full textObjectives: In the present study, therapeutic effects of the Cimicifuga racemosa preparation CR BNO 1055 (Klimadynon(R)/Menofem(R)) on climacteric complaints, bone metabolism and endometrium will be compared with those of conjugated estrogens (CE) and placebo. The question whether CR BNO 1055 contains substances with selective estrogen receptor modulator (SERM) activity will be investigated. Methods: Sixty-two evaluable postmenopausal women were included in the double-blind, randomized, multicentre study, and treated either with CR BNO 1055 (daily dose corresponding to 40 mg herbal drug), 0.6 mg CE, or matching placebo, for 3 months. Menopausal symptoms were assessed by the, menopause rating scale (MRS) and a diary. Levels of CrossLaps (marker of bone degradation) were determined by ELECSYS system and bone-specific alkaline phosphatase (marker of bone formation) by an enzymatic assay. Endometrial thickness was measured via transvaginal ultrasound; vaginal cytology was also studied. The primary efficacy criterion was the change from baseline to end point in the MRS. Change from baseline was analyzed for the secondary variables too. Results: CR BNO 1055 proved to be equipotent to CE and superior to placebo in reducing climacteric complaints. Under both preparations, beneficial effects on bone metabolism have been observed in the serum. CR BNO 1055 had no effect on endometrial thickness, which was significantly increased by CE. Vaginal superficial cells were increased under CE and CR BNO 1055 treatment. Conclusion: The results concerning climacteric complaints and on bone metabolism indicate an equipotent effect of CR BNO 1055 in comparison to 0.6 mg CE per day. It is proposed that CR BNO 1055 contains substances with SERM activity, i.e. with desired effects in the brain/hypothalamus, in the bone and in the vagina, but without exerting uterotrophic effects. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved
Effects of 20-OH ecdysone, a spinach (Spinacia oleracea) derived steroid, on metabolic and temperature regulatory parameters
No full textEffects of 20-OH ecdysone, a spinach (Spinacia oleracea) derived steroid, on metabolic and temperature regulatory parameters
No full textEffects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study
No full textObjectives: In this study, the effects of the Cimicfuga racemosa (CR) preparation CR BNO 1055 on markers of bone metabolism, hormones, sex hormone-binding globulin (SHBG), lipid metabolism, vaginal maturity, and routine laboratory parameters were compared with those of conjugated estrogens (CE) and placebo. Design: Sixty-two postmenopausal women were included in this double-blind study. Treatment duration with CR (daily dose corresponds to 40 mg of herbal drug), CE (0.6 mg/day), or placebo was 12 weeks. Markers of bone turnover (bone-specific alkaline phosphatase, CrossLaps), estradiol, follicle-stimulating hormone, luteinizing hormone, SHBG, triglycerides, total cholesterol, high-density cholesterol, low-density cholesterol, and routine clinical chemistry parameters were determined from blood samples. Vaginal "maturity index" was determined from vaginal smears. Results: The analyses of bone turnover markers indicated beneficial effects for CR and CE on bone metabolism. CR stimulated osteoblast activity, whereas CE inhibited osteoclast activity. Whereas CE showed strong estrogenic effects on vaginal mucosa, CR showed weak estrogenlike activity. No significant effects were seen on coagulation markers and liver enzymes in the blood. CR was well tolerated. Conclusion: These results suggest that CR has beneficial bone remodeling and weak estrogen-like effects in the vaginal mucosa
The Tombs of the Caliphs
No full textback: "C. Wuttke: Gräber der Kalifen -- The tombs of the caliphs - Les Tombeaux des Califes : R130. R. & J. D."Reproduction of an oil painting of two tombs at sundow
In drei Schritten zum wissenschaftlichen Poster
No full textPoster und Abstract “In drei Schritten zum wissenschaftlichen Poster” von P. Helwig, E. Kautz und C. Mina, Handreichung erarbeitet im EW-Kurs “Studierende auf der DHd-Konferenz“, WS 2020/2021, unter der Leitung von Dr. Ulrike Wuttke, Vertretungsprofessorin am Fachbereich Informationswissenschaften der Fachhochschule Potsdam.
Für den Hintergrund siehe auch: https://ulrikewuttke.wordpress.com/?p=213
Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17 beta in ovariectomized rats
No full textWhether urinary incontinence in the postmenopause can be prevented or delayed by estrogens is currently controversially debated. Ovariectomized (ovx) rats have been successfully used as models in the past years but plant derived substances with estrogenic effects in the lower urinary tract have not been studied so far. Therefore we compared the effects of a 3 months lasting oral administration of estradiol 17 beta (E2) with those of the phytoestrogens equol, genistein and puerarin. They were ovariectomized, fed with test substance containing food and then anaesthetized and catheterized with a biluminal catheter having one outlet in the bladder and another in the urethra at the level of the urethral sphincter. Urethral and bladder pressure were recorded during a 240 s period of retrograde bladder filling (2 x 0.5 ml within 30 s with 1 min filling intermission). Bladder and urethra pressures were highest in the E2 > puerarin > equol > genistein treated animals. Phytoestrogen and E2 treatment resulted in consistently higher urethral than the bladder pressures during the filling period and in the filled status whereas bladder often exceeded urethral pressures in ovx controls. In summary, we demonstrate significant improvement of urethral closure mechanism under E2 and phytoestrogen administration that can be assumed to be beneficial for prevention or therapy of postmenopausal urge incontinence. (C) 2009 Elsevier Inc. All rights reserved.European network of Excellence CASCADE [Food-CT-2004-506319
Wuttke, Karl Friedrich Adolf
No full textTiedja, Johannes. - Tittmann, Daniel Christian. - Tittmann, Daniel. - Tittmann, Karl Christian. - Treschow, Niels. - Troitzsch, Johann Gottlob. - Troschel, Jakob Elias. - Varrentrapp, Franz. - Vater, Johann Severin. - Villers, Charles François Dominique de. - Vol(c)kmar, Gustav Hermann Joseph Philipp. - Vorbrodt, Gustav Theodor Ferdinand Franz. - Wuttke, Karl Friedrich Adolf. - In: Biographisch-bibliographisches Kirchenlexikon / begr. u. hrsg. von Friedrich Wilhelm Bautz. Fortgef. von Traugott Bautz. - Herzberg : Bautz. - Bd. 12. (1997). - Sp. 43-67, 193-197, 201-230, 458-474, 567-578, 581-617, 1123-1140, 1146-1167, 1402-1414, 1570-1588. - Bd. 13. (1998). - Sp. 74-84. - Bd. 14 (1998). - Sp. 200-24
20-OH-Ecdysone Prevents Hot Flushes in Ovariectomized Rats
No full textHot flushes are due to the lack of estrogens and are the most characteristic climacteric complaints. Hormone replacement therapy was the standard treatment but now its use is limited because of side effects. Need therefore arises to search for non-estrogenic alternatives. The molting hormone 20-beta-hydroxyecdysone (Ecd) is produced by several plants including spinach and has no estrogenic or androgenic properties but enhances GABAergic effects in neurons. Since GABAergic compounds can ameliorate hot flushes, we investigated the effects of Ecd on subcutaneous body temperature of intact and ovariectomized (ovx) rats. The subcutaneous body temperature was recorded at 5-min intervals over a period of 3 hours. Rats were then ovx, and skin temperatures were recorded after an acute intravenous (5 mg) and during subchronic and chronic oral application of Ecd (73 mg/animal/day). For additional control purposes, a group of ovx rats received food containing estradio1-17 beta (E2). Skin temperature in individual ovx animals fluctuated largely with peaks (hot flushes) occurring every 20-40 minutes. Following the i.v. treatment with Ecd, skin temperature dropped by more than 1 degrees C, an effect much larger than in the controls. One and two weeks later, hot flushes were only seen in ovx controls but not in intact, E2-, or Ecd-treated animals. As a consequence, E2 and Ecd intake significantly (p < 0.05) reduced the mean temperature in ovx rats during the various time points of the study. These results suggest that Ecd is efficient to prevent hot flushes in ovx rats.VerdeVital Gmb
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