1,720,969 research outputs found
Crystallography of vitamin B12 proteins
No full textThis review deals with results from crystallographic studies on proteins that interact with the essential micronutrient cobalamin (vitamin B12). Both B12-dependent enzymes and B12-transport proteins are described with an emphasis on structural aspects of cobalamin and its protein environment
Vitamin B12 Transport Proteins: Crystallographic Analysis of beta-axial Ligand Substitutions in Cobalamin Bound to Transcobalamin
No full text
A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography.
No full textDiscovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe–Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture
Biocrystallographic study on drug resistant variants of HIV protease with new inhibitors
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
