33 research outputs found
Optimal Designs of Wound Field Switched Flux Machines with Different DC Windings Configurations
No full textWound field switched flux (WFSF) machines exhibits characteristics of the simple robust rotor, flexible flux-adjustable capability, and no risk of demagnetization. However, they suffer from a poor torque density compared with permanent magnet machines due to the saturation. Therefore, in this paper, two WFSF machines with single- and double-layer DC windings, respectively, are optimized for the maximum torque. The end-winding (EW) lengths differ in these two machines, which can affect the optimal design. Design parameters including the DC to armature winding copper loss ratio, slot area ratio and split ratio are optimized when two machines have the same copper loss and overall sizes. In addition, the influence of the flux density ratio, total copper loss, air-gap length and aspect ratio on the optimal split ratio is investigated using the finite element method and results are explained through the analytical model accounting for the saturation. It is discovered that the EWs have no effect on the optimal copper loss ratio, which is unity. In terms of the slot area ratio, the machine with single-layer DC windings prefers smaller DC slot areas than armature slot areas. In the WFSF machine with longer EWs, the optimal split ratio becomes smaller. Moreover, compared with other parameters, the flux density ratio can significantly affect the optimal split ratio
Genome Sequence of Rhodoferax antarcticus ANT.BRT; A Psychrophilic Purple Nonsulfur Bacterium from an Antarctic Microbial Mat
Get PDFabstract: Rhodoferax antarcticus is an Antarctic purple nonsulfur bacterium and the only characterized anoxygenic phototroph that grows best below 20 °C. We present here a high-quality draft genome of Rfx. antarcticus strain ANT.BR[superscript T], isolated from an Antarctic microbial mat. The circular chromosome (3.8 Mbp) of Rfx. antarcticus has a 59.1% guanine + cytosine (GC) content and contains 4036 open reading frames. In addition, the bacterium contains a sizable plasmid (198.6 kbp, 48.4% GC with 226 open reading frames) that comprises about 5% of the total genetic content. Surprisingly, genes encoding light-harvesting complexes 1 and 3 (LH1 and LH3), but not light-harvesting complex 2 (LH2), were identified in the photosynthesis gene cluster of the Rfx. antarcticus genome, a feature that is unique among purple phototrophs. Consistent with physiological studies that showed a strong capacity for nitrogen fixation in Rfx. antarcticus, a nitrogen fixation gene cluster encoding a molybdenum-type nitrogenase was present, but no alternative nitrogenases were identified despite the cold-active phenotype of this phototroph. Genes encoding two forms of ribulose 1,5-bisphosphate carboxylase/oxygenase were present in the Rfx. antarcticus genome, a feature that likely provides autotrophic flexibility under varying environmental conditions. Lastly, genes for assembly of both type IV pili and flagella are present, with the latter showing an unusual degree of clustering. This report represents the first genomic analysis of a psychrophilic anoxygenic phototroph and provides a glimpse of the genetic basis for maintaining a phototrophic lifestyle in a permanently cold, yet highly variable, environment.The final version of this article, as published in Microorganisms, can be viewed online at: http://www.mdpi.com/2076-2607/5/1/
Progress of titanium-based laminated materials by powder metallurgy
Get PDFBased on the increasingly severe working environment, properties of titanium materials are facing the new challenges as the superior combination of strength and ductility. The design of laminated structure provides a new idea to achieve the remarkable strength-ductility enhancement of titanium-based materials. In recent years, titanium-based laminated materials have become the research hotspot. Titanium-based laminated materials obtained by different preparation techniques show excellent mechanical properties. Powder metallurgy technology has numerous advantages of simple and efficient process, by which the component control and the optimization of mechanical properties can be easily achieved. The main types and metallurgical processing of titanium-based laminated materials were described in this paper. The research progress of titanium-based laminated materials obtained by powder metallurgy was introduced, and strengthening and toughening mechanism of the high-performance titanium-based laminated structure materials was summarized. Finally, the basic research and practical application of the titanium-based laminated materials were prospected briefly
Radiation Dose Reduction by Using CT with Iterative Model Reconstruction in Patients with Pulmonary Invasive Fungal Infection
No full textClinical, radiological, pathological and prognostic aspects of intraventricular oligodendroglioma: comparison with central neurocytoma
No full textEstablishment of a novel quantum dots-encoded microbead-based flow cytometric method for quantification of soluble FcεRIα in serum
No full textMagnetic/Fluorescent Barcodes Based on Cadmium‐Free Near‐Infrared‐Emitting Quantum Dots for Multiplexed Detection
No full textCombined DLL3-targeted bispecific antibody with PD-1 inhibition is efficient to suppress small cell lung cancer growth
No full textBackground Small cell lung cancer (SCLC) accounts for 15% of lung cancers, and the primary treatment of this malignancy is chemotherapy and radiotherapy. Delta-like 3 (DLL3) is an attractive target for SCLC immunotherapy since its expression is highly restricted to SCLC with a neglectable appearance on normal adult tissues. In the current study, we aimed to explore the efficacy of DLL3-targeted SCLC immunotherapy via the engagement of T cell.Methods As a proof of concept, we constructed DLL3-targeted bispecific antibody and chimeric antigen receptor (CAR)-modified T cells. In vitro and in vivo tumor-suppression activity of these treatments alone or in combination with a Program Death-1 (PD-1) inhibitory antibody was evaluated.Results In vitro studies showed that both DLL3 bispecific antibody and CAR-T efficiently killed DLL3-positive cancer cells, including the native SCLC cell lines H446, H196, H82, and the artificial A431 cells that were forcefully overexpressing DLL3. In vivo studies in xenograft mouse models demonstrated that both bispecific antibody and CAR-T suppressed the tumor growth, and combination therapy with PD-1 inhibitory antibody dramatically improved the efficacy of the DLL3 bispecific antibody, but not the CAR-T cells.Conclusions Our results demonstrated that DLL3-targeted bispecific antibody plus PD-1 inhibition was effective in controlling SCLC growth
A partial least squares-based stimulus frequency recognition model for steady-state visual evoked potentials detection
No full textQuantum Dots: Magnetic/Fluorescent Barcodes Based on Cadmium‐Free Near‐Infrared‐Emitting Quantum Dots for Multiplexed Detection (Adv. Funct. Mater. 42/2016)
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