7,213 research outputs found
Perancangan Sistem Informasi Pengelola Barang/Inventaris Di Jc Komp
No full textInventory information system is a system used to enter inventory data into the database, so that there are no errors in input, output data, and reporting based on the desired data. based on surveys and interviews with jc comp personnel, information was obtained that the existing system in the jc comp warehouse section is still manual. therefore, the system that will be created by the author is the result of a replication of the existing system in the jc comp warehouse section. in addition to the process of input and output of goods, this information system is also equipped with features for creating data reports, input and output of goods, and searching for goods data by item name. with the inventory information system is expected to be useful for the warehouse parts jc comp. By implementing this system in the jc comp warehouse, it is hoped that it can reduce errors that may occur. this system is also expected to further speed up the process of input, output, and report generation, which in turn will help the jc comp warehouseSistem Informasi Persediaan Barang adalah sebuah sistem yang digunakan untuk memasukkan data-data persediaan barang ke dalam database, sehinggga tidak terjadi kesalahan dalam input, output data, dan pembuatan laporan berdasarkan data yang diinginkan. Berdasarkan survey dan wawancara dengan bagian personalia Jc Komp, didapatkan informasi bahwa sistem yang ada dibagian gudang Jc Komp masih manual. Oleh karena itu, sistem yang akan dibuat oleh penulis adalah hasil replikasi dari sistem yang telah ada dibagian gudang Jc Comp. Selain proses input dan output barang, pada sistem informasi ini juga dilengkapi fitur pembuatan laporan data, input, dan output barang, dan pencarian data barang berdasarkan nama barang. Dengan adanya Sistem Informasi persediaan barang ini diharapkan dapat bermanfaat bagi bagian gudang Jc Komp. Dengan diterapkannya sistem ini pada bagian gudang Jc Comp, maka diharapkan dapat mengurangi kesalahan-kesalahan yang mungkin terjadi. Sistem ini juga diharapkan dapat lebih mempercepat proses input, output, dan pembuatan laporan yang pada akhirnya dapat membantu bagian gudang Jc Komp
Amenable L-2-Theoretic Methods and Knot Concordance
No full textWe reveal new structures in the topological knot concordance group. As a key ingredient, we develop obstructions using L-2-theoretic methods for amenable groups in Strebel's class recently introduced by Orr and the author. Concerning (h)-solvable knots, which are defined in terms of certain Whitney towers of height h in bounding 4-manifolds, we show the following: for any n>1, there are (n)-solvable but non-(n. 5)-solvable (and therefore nonslice) knots, which are not detected by prior methods using Cochran-Orr-Teichner L-2-signature obstructions as well as Levine algebraic obstructions and Casson-Gordon invariants.X1197sciescopu
Investigation of damage in laminated carbon fibre composites using high resolution computed tomography
No full textLaminated fibre reinforced polymer matrix composites have been used in design and manufacture for more than 50 years, exploiting desirable material properties such as high specific strength and stiffness, enabling large weight savings to be made on structural components. To take full advantage of this class of materials a comprehensive knowledge of behaviour under different service conditions is required. This thesis illustrates the degree to which this is currently achieved, and describes the motivation and progression of an experimental and theoretical analysis of the static damage growth in carbon fibre reinforced polymers.Notched carbon fibre-epoxy cross-ply composite samples have been manufactured and loaded in uni-axial tension. Synchrotron radiation computed tomography (SRCT) has been used to characterise in 3-D the initiation and evolution of damage during in situ loading. Characteristic splitting, off-axis matrix cracking, interlaminar cracking and fibre failure within the samples were identified and the interaction of the damage mechanisms during crack growth has been evaluated. Splitting in the plies aligned with the loading direction was studied in greater detail, including measurements of crack opening displacement and shear deformation at crack flanks.3-D finite element models of splitting have been developed based on the observed damage and specimen microstructure from the SRCT results. Thermal residual stress and mechanical loading conditions were simulated for comparison with the experimental findings. Effects of local microstructural inhomogeneities were also embedded in models of varying complexity to assess the degradation of the results or model predictions due to simplifications or homogenisation. Significant discrepancy was found between the measured experimental data and finite element predictions due to simplifications in the model. Likely candidates for the over-prediction of crack growth include the effects of transverse ply cracks, delaminations and the lack of symmetrical damage formulation. Of particular significance is the confirmation that, via qualitative observations and quantitative data extraction, SRCT has facilitated the first known instance of direct full field comparison of model predictions for composite damage for a practical engineering layup
Dynamics of Network Formation Processes in the Co-Author Model
No full textThis article studies the dynamics in the formation processes of a mutual consent network in game theory setting: the Co-Author Model. In this article, a limited observation is applied and analytical results are derived. Then, 2 parameters are varied: the number of individuals in the network and the initial probability of the links in the network in its initial state. A simulation result shows a finding that is consistent with an analytical result for a state of equilibrium while it also shows different possible equilibria.Dynamics, Network, Game Theory, Model,Simulation, Equilibrium, Complexity
Malignant transformation by H‐ras results in aberrant regulation of ribonucleotide reductase gene expression by transforming growth factor‐β1
No full textRibonucleotide reductase is a key rate-limiting and regulatory step in DNA synthesis and plays a crucial role in the coordination of DNA synthesis, DNA repair, and cell proliferation. The present study demonstrates a link between alterations in TGF-beta(1) regulation during malignant conversion and the expression of ribonucleotide reductase. H-ras-transformed mouse 10T1/2 cell lines exhibiting malignant potential were examined for possible TGF-beta(1)-mediated alterations in ribonucleotide reductase expression. Selective induction of ribonucleotide reductase gene expression occurred, since only H-ras-transformed highly metastatic cells exhibited marked elevations in ribonucleotide reductase expression, whereas nontransformed normal 10T1/2 cells were unaffected by TGF-beta(1) treatment. These changes occurred without any detectable modifications in DNA synthesis rates, suggesting that these changes were regulated by a novel mechanism independent of the S-phase of the cell cycle. Furthermore, this TGF-beta(1)-mediated regulation of ribonucleotide reductase expression was shown to occur through an autocrine mechanism. TGF-beta(1)-modulated regulation of ribonucleotide reductase expression requires de novo protein synthesis and involves, at least in part, transcriptional and post-transcriptional events. Furthermore, evidence is presented to suggest a possible role for protein kinase C-mediated events, protein phosphatases, and G-protein-coupled events in the TGF-beta(1)-mediated regulation of ribonucleotide reductase expression in H-ras-transformed malignant cells. TGF-beta(1) regulation of ribonucleotide reductase in highly malignant cells appears to be complex and multifaceted and constitutes an integral part of an altered growth regulatory program. (C) 1995 Wiley-Liss, Inc.PT: J; CR: ALBERT DA, 1989, J CELL PHYSIOL, V138, P129 AMARA FM, 1993, NUCLEIC ACIDS RES, V21, P4803 AMARA FM, 1994, J BIOL CHEM, V269, P6709 BJORKLUND S, 1990, BIOCHEMISTRY-US, V29, P5452 BRUNNER AM, 1989, J BIOL CHEM, V264, P13660 CHAMBARD JC, 1987, NATURE, V326, P800 CHAN AK, 1993, BIOCHEMISTRY-US, V32, P12835 CHEN FY, 1993, EMBO J, V12, P3977 CHOY BK, 1989, BIOCHEM BIOPH RES CO, V162, P1417 COHEN P, 1990, TRENDS BIOCHEM SCI, V15, P98 CORY JG, 1972, CANCER RES, V32, P1301 EGAN SE, 1987, MOL CELL BIOL, V7, P830 EGAN SE, 1987, SCIENCE, V238, P202 FELGNER PL, 1987, P NATL ACAD SCI USA, V84, P7413 FISCHER JB, 1988, J BIOL CHEM, V263, P2808 GENTRY LE, 1988, MOL CELL BIOL, V8, P4162 GOUGH NM, 1988, ANAL BIOCHEM, V173, P93 GREENBERG AH, 1989, INVAS METAST, V9, P360 GRUPPUSO PA, 1991, J BIOL CHEM, V266, P3444 HARDS RG, 1981, J CELL PHYSIOL, V106, P309 HOWE PH, 1989, CANCER RES, V49, P6024 HURTA RAR, 1990, BIOCHIM BIOPHYS ACTA, V1087, P165 HURTA RAR, 1991, J BIOL CHEM, V266, P24897 HURTA RAR, 1992, BIOCH CELL BIOL, V70, P1081 HURTA RAR, 1992, J BIOL CHEM, V267, P7066 HURTA RAR, 1994, J CELL PHYSL, V158, P187 JAKOWLEW SB, 1988, ONCOGENE RES, V2, P135 KATAOKA R, 1993, J BIOL CHEM, V268, P19851 KIM SJ, 1990, MOL CELL BIOL, V10, P1492 LE AQ, 1992, J BIOL CHEM, V267, P1072 LEWIS WH, 1978, J CELL PHYSL, V94, P287 LUTTRELL LM, 1988, J BIOL CHEM, V263, P6134 MCCLARTY GA, 1986, SOMAT CELL MOLEC GEN, V12, P121 MCCLARTY GA, 1987, BIOCHEMISTRY-US, V26, P8004 MCCLARTY GA, 1990, J BIOL CHEM, V265, P7539 MUKHERJEE R, 1987, J BIOL CHEM, V262, P13697 NICOLSON GL, 1984, CANCER METAST REV, V3, P25 NISHIZUKA Y, 1986, SCIENCE, V233, P305 PELECH SL, 1990, BIOCHEM CELL BIOL, V68, P1297 PENTTINEN RP, 1988, P NATL ACAD SCI USA, V85, P1105 PERTOVAARA L, 1989, MOL CELL BIOL, V9, P1255 PHILLIPS DR, 1986, BIOCHEMISTRY-US, V25, P7355 RAGHOW R, 1987, TRENDS BIOCHEM SCI, V12, P358 RALPH RK, 1990, BIOESSAYS, V12, P121 ROBERTS AB, 1988, BRIT J CANCER, V57, P594 SAMUEL SK, 1992, EMBO J, V11, P1599 SASSA T, 1989, BIOCHEM BIOPH RES CO, V159, P939 SCHWARZ LC, 1988, CANCER RES, V48, P6999 SCHWARZ LC, 1990, GROWTH FACTORS, V3, P115 SPORN MB, 1990, CELL REGUL, V1, P875 STEEPER JR, 1970, ANAL BIOCHEM, V34, P123 TAMM I, 1978, ADV VIRUS RES, P187 THELANDER L, 1980, J BIOL CHEM, V255, P7426 ULLMAN B, 1979, P NATL ACAD SCI USA, V76, P1074 WAKEFIELD LM, 1987, J CELL BIOL, V105, P965 WEBER G, 1983, CANCER RES, V43, P3466 WEINBERG G, 1981, P NATL ACAD SCI USA, V78, P2447 WEINBERG RA, 1989, ONCOGENES MOL ORIGIN, P46 WILDER PJ, 1991, CANCER RES, V51, P5898 WRIGHT JA, 1989, INT ENCY PHARM THERA, V128, P89 WRIGHT JA, 1990, ANTICANCER RES, V10, P1247 WRIGHT JA, 1990, BIOCH CELL BIOL, V68, P1364 WRIGHT JA, 1993, CRIT REV ONCOGENESIS, V4, P473 YOUNG S, 1987, BIOCHEM J, V244, P775; NR: 64; TC: 25; J9: J CELL BIOCHEM; PG: 14; GA: QJ118Source type: Electronic(1
High-level polyomavirus JC viruria following long-term steroid therapy
No full textCASE REPORT JC virus is a highly seroprevalent ubiquitous polyomavirus which is acquired at an early age through respiratory or oral route, Thereafter JCV establishes persistent, but mainly asymptomatic, infections in various tissues, including the genitourinary tract and brain Corresponding author Cristina Costa, MD S.C.D.U. Virologia Azienda Ospedaliero-Universitaria San Giovanni Battista di Torino Via Santena, 9 -10126 Torino E-mail: [email protected] increasing with age, with adult prevalence rate often between 15% and 60
Engineering Framework to Utilize Miniaturized Charpy Type SE(B) Specimens to Predict Jc of Full Sized Specimens
No full textAbstractThis paper introduces our experience of using miniature Charpy type SE(B) specimen in obtaining fracture toughness Jc of a material in the ductile to brittle transition temperature (DBTT) region. Width W x thickness B of 2 x 2 mm, 3 x 3 mm and 10 x 10 mm were chosen as miniature specimens and 25 x 25 mm were chosen as full sized specimen. 0.55% carbon steel JIS S55C, whose tensile to yield stress ratio σTS/σYS was equal to 1.8 was chosen as a material to simulate a degraded (embrittled) material in the DBTT region. Focus was placed on whether cleavage fracture could be predicted for these miniaturized specimens. Another focus was placed on whether the Jc of full sized specimen is predictable from the test results of the miniature sized specimens, in case cleavage fracture were observed. The results showed that the modified Ritch-Knott-Rice (RKR) failure criterion (which predicts the onset of cleavage fracture when the crack opening stress measured at 4 times the crack-tip opening displacement exceeds this σ22c) could predict whether cleavage fracture would occur or not. Another finding was that, in case cleavage fracture was observed though, the critical value σ22c in the modified RKR failure criterion was independent of specimen size, and thus, Jc of the full sized specimen is predictable from the miniature specimen test results, though M = (W-a)σYS/Jc was smaller than ASTM E1921 requirement of 30. Here, a and σYS are crack length and yield strength, respectively
Supplementary_file_-_Lay_health_worker_role_description - The lay health worker–patient relationship in promoting pulmonary rehabilitation (PR) in COPD: What makes it work?
No full textSupplementary_file_-_Lay_health_worker_role_description for The lay health worker–patient relationship in promoting pulmonary rehabilitation (PR) in COPD: What makes it work? by Gill Gilworth, Simon Lewin, Alison J Wright, Stephanie JC Taylor, Rachel Tuffnell, Lauren Hogg, Nicholas S Hopkinson, Sally J Singh and Patrick White in Chronic Respiratory Disease</p
Teamwork reduces physiological stress in junior surgeons
No full textObjective:
The quality of teamwork depends not only on communication
skills but also on team familiarity and hierarchical structures. The aim of the
present study is to evaluate the physiological impact of close teamwork between
senior and junior surgeons performing elective open abdominal surgery for six
months in stable teams.
Methods:
Physiological measurements of the main and junior surgeons were
taken in a total of 40 procedures. Cumulative stress was assessed by the mea-
surements of urine catecholamines (Adrenaline, Noradrenaline, Dopamine, Metanephrine, Normetanephrine). Heart rate variability was measured to
assess temporal aspects of stress. The procedures were observed by a trained
team of work psychologists. Direct observations of distractors, team inter-
actions and communication were performed. Specific questionnaires were
filled by members of the surgical team that include surgeons, nurses and
anesthetists.
Results:
In junior surgeons, physiological stress is reduced over a period
of close collaboration. Case-related communication is not stressful. However,
tension within the surgical team is associated with increased levels of cat-
echolamine in the urine of the senior surgeon. The difficulty of the oper-
ation impacts on heart-rate variability of the junior but not of the senior
surgeon.
Conclusion:
Junior surgeons may require months of teamwork within one
stable team in order to reduce levels of physiological stress. Senior surgeons are
more resistant to stressful clinical situations compared to junior surgeons but
are vulnerable to tension within the surgical team
Early stages of development of rat brain tumors induced by JC virus: a sequential histological and immunohistochemical study.
No full textIn order to clarify the origin of JC virus-induced brain tumors in rats, the development of tumors was sequentially analyzed histologically and immunohistochemically. Twenty-two of 30 rats (73%), which were intracerebrally inoculated with JC virus within 24 h of birth (group 1), developed, as a group, 45 brain tumors after 12 to 26 weeks. Seventeen of 27 rats (63%), which were inoculated on the 7th day after birth (group 2), developed 37 brain tumors as a group after a time 12 to 40 weeks. The tumors were found exclusively in the cerebrum. The microtumors, which were defined as tumors less than 2 mm in diameter, were located in the subependymal plate around the ventricular system. The microtumors and most part of the macrotumors consisted of cells of undifferentiated neuroectodermal nature, showing nuclear palisades and Homer-Wright-pseudorosette-like structures. Some tumor cells of macrotumors had an astrocytic nature and were positive for glial fibrillary acidic protein, S-100, Leu 7, and vimentin. In conclusion, the target cells of JC virus in rats may be undifferentiated subependymal cells of the cerebrum. The tumor cells show partial glial differentiation as they grow.</p
- …
