74 research outputs found
Hırs ve Başarı
No full textOrison Swett Marden's Hırs ve Başarı (Ambition and Success) is an inspirational self-help book focused on unlocking individual potential and living a fulfilling life. The author defines ambition not merely as a desire but as a divine impulse that constantly propels humans upward and forward. The book explains how a healthy ambition can overcome obstacles such as inertia, procrastination, and dissatisfaction, transforming an ordinary life into an extraordinary success story. While criticising "unworthy ambitions" focused solely on material gain, Marden emphasises the importance of "noble ambitions" centred on character development and contribution to society. Touching on the impact of the environment and the choice of friends on success, the author advocates the power of envisioning oneself in a better position and remaining loyal to that vision. The work conveys the message that, regardless of age or circumstances, humans can determine their own destiny by activating their latent powers.Orison Swett Marden'in Hırs ve Başarı adlı eseri, bireysel potansiyeli açığa çıkarma ve tatmin edici bir yaşam sürme üzerine odaklanan ilham verici bir kişisel gelişim kitabıdır. Yazar, hırsı (ambition) sadece bir istek değil, insanı sürekli yukarıya ve ileriye taşıyan, Tanrısal bir dürtü olarak tanımlar. Kitapta, sağlıklı bir hırsın; atalet, erteleme ve tatminsizlik gibi engelleri nasıl aşabileceği ve sıradan bir yaşamı nasıl olağanüstü bir başarı öyküsüne dönüştürebileceği anlatılır. Marden, sadece maddi kazanç odaklı "değersiz hırsları" eleştirirken, karakter gelişimini ve topluma katkıyı merkeze alan "asil hırsların" önemini vurgular. Çevrenin ve arkadaş seçiminin başarı üzerindeki etkisine değinen yazar, kişinin kendini daha iyi bir konumda hayal etmesinin (vizyonun) ve bu hayale sadık kalmasının gücünü savunur. Eser, yaş veya koşullar ne olursa olsun, insanın içindeki gizli güçleri harekete geçirerek kendi kaderini tayin edebileceği mesajını verir
Obesidad en la altura
No full textObesity is considered an epidemic disease. It is a risk factor for diabetes mellitus type 2 and some other metabolic and neoplastic disorders. The national and worldwide prevalence of obesity at high altitude and the relation between obesity and chronic and acute hypoxia at high altitude are revised.La obesidad es considerada como una epidemia. Es un factor de riesgo para el desarrollo de diabetes mellitus de tipo 2 y otras comorbilidades. Se revisa la prevalencia de obesidad en la altura a nivel nacional y mundial, así como también la relación entre hipoxia crónica y aguda con la obesidad
Temporal trends in obesity defined by the relative fat mass (RFM) index among adults in the United States from 1999 to 2020: a population-based study
No full textObjectives The body mass index (BMI) largely underestimates excess body fat, suggesting that the prevalence of obesity could be underestimated. Biologically, women are known to have higher body fat than men. This study aimed to compare the temporal trends in general obesity by sex, ethnicity and age among adults in the USA using the relative fat mass (RFM), a validated surrogate for whole-body fat percentage and BMI.Design Population-based study.Setting US National Health and Nutrition Examination Survey, from 1999–2000 to 2017–March 2020.Participants A representative sample of adults 20–79 years in the USA.Main outcome measures Age-adjusted prevalence of general obesity. RFM-defined obesity was diagnosed using validated cut-offs to predict all-cause mortality: RFM≥40% for women and ≥30% for men. BMI-defined obesity was diagnosed using a cut-off of 30 kg/m2.Results Analysis included data from 47 667 adults. Among women, RFM-defined obesity prevalence was 64.7% (95% CI 62.1% to 67.3%) in 2017–2020, a linear increase of 13.9 percentage points (95% CI 9.0% to 18.9%; p<0.001) relative to 1999–2000. In contrast, the prevalence of BMI-defined obesity was 42.2% (95% CI 39.4% to 45.0%) in 2017–2020. Among men, the corresponding RFM-defined obesity prevalence was 45.8% (95% CI 42.0% to 49.7%), a linear increase of 12.0 percentage points (95% CI 6.6% to 17.3%; p<0.001). In contrast, the prevalence of BMI-defined obesity was 42.0 (95% CI 37.8% to 46.3%). The highest prevalence of RFM-defined obesity across years was observed in older adults (60–79 years) and Mexican Americans, in women and men. Conversely, the highest prevalence of BMI-defined obesity across years was observed in middle-age (40–59 years) and older adults, and in African American women.Conclusions The use of a surrogate for whole-body fat percentage revealed a much higher prevalence of general obesity in the USA from 1999 to 2020, particularly among women, than that estimated using BMI, and detected a disproportionate higher prevalence of general obesity in older adults and Mexican Americans
Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases
No full textAssociation of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality
No full textAbstract Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly investigated. In addition, no study has compared the associations of RFM and waist circumference (a surrogate for intra-abdominal fat) with cause-specific mortality and all-cause mortality. In the present study, we addressed these knowledge gaps. We used data from the US National Health and Nutrition Examination Survey (NHANES) 1999–2018. NHANES III was used for validation. Analyses included 46,535 adults (mean age 46.5 years). During a median follow-up time of 9.7 years, 6,101 participants died (743 from diabetes; 1,514 from heart disease). Compared with BMI and WC, RFM was more strongly associated with diabetes-related mortality in both women and men, adjusting for age, ethnicity, education, and smoking status. All anthropometric measures were similarly strongly associated with heart disease mortality and all-cause mortality. RFM showed greater predictive discrimination of mortality. Similar results were found in NHANES III (n = 14,448). In conclusion, RFM is strongly associated with diabetes-related mortality, heart disease mortality, and all-cause mortality, and outperforms conventional adiposity measures for prediction of mortality
Chlamydia pneumoniae y aterosclerosis: Mecanismos patogénicos
No full textAtherosclerosis is a chronic inflammatory process in which macrophages, smooth muscle cells, T lymphocytes, and several chemical mediators intervene. In recent years, the finding of Chlamydia pneumoniae in arterial atherosclerotic plaques has suggested an etiological role; however, whether C. pneumoniae causes atherosclerosis or precipitates or favors atheroesclerosis progression remains uncertain. We review studies published on-line or available in Lima specialized libraries regarding C. pneumoniae and atherosclerosis association, with special emphasis on the pathogenic role of this bacteria.La aterosclerosis es un proceso inflamatorio crónico en donde intervienen macrófagos, células musculares lisas y linfocitos T, además de un conjunto de mediadores químicos. En los últimos años, el hallazgo de Chlamydia pneumoniae en placas ateroscleróticas en diferentes regiones de nuestro cuerpo ha sugerido un rol etiológico de este microorganismo en el proceso de aterogénesis. Sin embargo, todavía es incierto si la C. pneumoniae es el agente causal de la aterosclerosis o si constituye un factor que precipita o favorece su progresión. Se ha hecho una revisión de artículos publicados hasta la actualidad, disponibles como texto completo vía internet o en las bibliotecas especializadas de Lima, acerca de la asociación entre C. pneumoniae y aterosclerosis, poniendo énfasis en el rol patogénico de esta bacteria
Defining cutoffs to diagnose obesity using the relative fat mass (RFM): Association with mortality in NHANES 1999–2014
No full textGardner-Webb Prepares Nursing Veteran for Next Step in her Career
No full textRobin Sherrill (’16) of Statesville, N.C., has been in the nursing profession for 27 years. Throughout that time, she’s discovered the truth in this quote from author Orison Swett Marden: “If you do not feel yourself growing in your work and your life broadening and deepening, if your task is not a perpetual tonic to you, you have not found your place.”https://digitalcommons.gardner-webb.edu/gardner-webb-newscenter-archive/1892/thumbnail.jp
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