49,172 research outputs found
High-Resolution Simulation on Structure Formation with Extremely Light Bosonic Dark Matter
No full textHeterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Full text linkIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Isolation and characterization of adult stem cells derived from human rotator cuff tendons
No full textWave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
Value at Induced Risk (VaIR): Pohang template matching catalog and cut seismogram
No full text# README is written by J.-U. Woo ([email protected]).
Template earthquake catalog for Pohang earthquakes and cut seismogram at PHA2 station
Suggested citation for the uploaded catalog:
1. C. Langenbruch, W. L. Ellsworth, J.-U. Woo and D. J. Wald, 2020, Value at Induced Risk: Injection-induced seismic risk from low-probability, high-impact events. Geophysical Research Letters, 47, e2019GL085878. http://doi.org/10.1029/2019GL085878.
Further citations for Pohang seismicity:
2. W.L. Ellsworth, D. Giardini, J. Townend, S. Ge, and T. Shimamoto, 2019, Triggering of the Pohang, Korea, Earthquake (MW 5.5) by Enhanced Geothermal System Stimulation. Seismological Research Letters, 90(5), 1844-1858.
3. K.-K. Lee, W.L. Ellsworth, D. Giardini, J. Townend, S. Ge, T. Shimamoto, I.-W. Yeo, T.-S. Kang, J. Rhie, D.-H. Sheen, C. Chang, J.-U. Woo, C. Langenbruch, 2019, Managing injection-induced seismic risks. Science, 364(6442), 730-732.
4. (Citation for the hypoDD location of the earthquakes in the catalog) J.‐U. Woo, M. Kim, D.‐H. Sheen, T.‐S. Kang, J. Rhie, F. Grigoli, W.L. Ellsworth, D. Giardini, 2019, An In‐Depth Seismological Analysis Revealing a Causal Link Between the 2017 MW 5.5 Pohang Earthquake and EGS Project, JGR solid earth, doi:10.1029/2019JB018368.
Description:
[1] VaIR.gz : Cut seismogram at PHA2 station. Each SAC file is named as "(station name).(ID of event).(component; E/N/Z).sac".
[2] Table_S1.txt : Template earthquake catalog.</p
The roles of clustered membrane proteins in T-cell signaling
Full text linkThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 157-163).Humans, like most other jawed vertebrates, are equipped with an adaptive immune system that can respond to diverse pathogens. Mature T cells, one of the most important immune cells generated from the thymus through a rigorous selection processes, are key orchestrators of the immune responses. Although many of the key signaling molecules in T cells have been discovered, the underlying mechanisms of how some of these signaling molecules interact with each other in space and time to trigger T cell activation have not yet been established. Furthermore, recent experimental results demonstrate that the membrane is a highly organized structure with some membrane proteins inhomogeneously distributed into clusters, which are often called protein islands or protein clusters. The roles of these clustered proteins remain to be established. For my thesis, to gain insights into the roles of protein islands in early T cell signaling, I have focused on important clustered proteins such as the T-cell receptor (TCR) and Linker of activated T cells (Lat). Active ZAP-70 molecules, which phosphorylate tyrosine residues of Lat molecules, are generated from the clustered TCR molecules. Using spatial Gillespie simulation and mathematical modeling, I found that clustered proteins may suppress the probability of spurious triggering of T cells. This finding may suggest an important role of clustered proteins, which may be relevant to other signaling networks and other cell types with spatially clustered proteins in the membrane. In addition, I have examined how the spatial organization of membrane proteins and the diffusivity of molecules affect the steady-state levels of key molecules required for T-cell activation: RasGTP and fully phosphorylated ITAM. I have also studied the correlation between the peptide repertoire presented by antigen-presenting cells in the thymus and the generation of autoreactive T cells as well as the TCR repertoire of peripheral T cells.by Woo K. Chung.Ph.D
E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel)
Full text linkArsip Kuliah Online 2010: E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel
Letter from Carl Hayden to P. J Moran
No full textLetter from Carl T. Hayden to P. J. Moran concerning the alignment of the road to Bright Angel Trail
E-book : "industrial Transformations In The Developing World (author: Michael T. Rock & David. P Angel)
Full text linkArsip Kuliah Online 2010: E-book : "industrial Transformations In The Developing World (author: Michael T. Rock & David. P Angel
Letter from P. J. Moran to Carl Hayden
No full textLetter from P. J. Moran to Carl T. Hayden inquiring when construction will begin on the approach road to Bright Angel Trai
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