6,419 research outputs found
The Effects of a "Fat Tax" on the Nutrient Intake of French Households
No full textThis article assesses the effects of a "fat tax" on the nutrient intake of French households across different income groups using a method that estimates the nutrient elasticities of French households. We estimate a complete demand system by aggregating an individual demand system over cohorts. The use of a cohort model is justified by the incompleteness of our data. We find that a "fat tax" would have ambiguous and extremely small effects on the nutrient intake of French households, and its associated economic welfare costs would be similarly weak.Household survey data, demand system, nutrient elasticities., Food Consumption/Nutrition/Food Safety,
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
No full textWaist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions
Old and new in fat grafting
No full textThe author traces the evolution of fat grafting over the years and shows the potential clinical applications in the different areas of the body
Regulation of fat-stimulated neurotensin secretion in healthy subjects
No full textCONTEXT: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release. OBJECTIVE: The aim of this study was to investigate whether CCK mediated the effect of intraduodenal (ID) fat on neurotensin secretion via CCK-1 receptors. SETTING: This was a single center study; 34 male volunteers were studied in consecutive, randomized, double-blind, cross-over studies. SUBJECTS AND METHODS: CCK and neurotensin release were quantified in: 1) 12 subjects receiving an ID fat infusion with or without 60 mg orlistat, an irreversible inhibitor of gastrointestinal lipases, in comparison to vehicle; 2) 12 subjects receiving ID long chain fatty acids (C18s), ID medium chain fatty acids, or ID vehicle; and 3) 10 subjects receiving ID C18 with and without the CCK-1 receptor antagonist dexloxiglumide or ID vehicle plus iv saline (placebo). Hormone concentrations were measured by specific RIA systems. RESULTS: ID fat induced a significant increase in CCK and neurotensin concentrations (P > 0.001-0.002). Inhibition of fat hydrolysis by orlistat abolished both effects. C18 stimulated CCK and neurotensin release (P > 0.001, respectively), whereas medium chain fatty acid was ineffective. Dexloxiglumide administration partially blocked the effect of C18 on neurotensin; the effect was only present in the first phase of neurotensin secretion. CONCLUSIONS: Generation of C18 through hydrolysis of fat is a critical step for fat-induced stimulation of neurotensin in humans; the signal is in part mediated via CCK release and CCK-1 receptors
Exercising exclusions : Space, visibility, and monitoring of the exercising fat female body
No full textThe author’s aim is to inspect the position of the fat (female) body in the field of exercise. Specifically, the author is interested in fat women’s experiences of their treatment while exercising in public, and argues that, in particular, public spaces for exercise, such as gyms and swimming pools, are currently discursively and concretely constructed as “exclusive” spaces for the normative bodied. Bodies that are deemed non-normative, such as fat bodies, are often made either invisible or intolerable in the discourse of physical activity and exercise. Consequently, public spaces for exercise such as gyms or swimming pools are seen as out of bounds for non-normative bodies and this is reflected in fat people’s experiences of their treatment doing exercise. Fat women in particular experience disrespectful treatment in such places: they are harassed, ridiculed, and commented on. As the material, the author uses a public discussion concerning fat people and exercise that took place in the Finnish media in the spring of 2015, and the author aims to show that to make physical activity and exercise more attractive to fat people, more attention should be paid to its discursive and practical construction as a space for all bodies.peerReviewe
Comparison of obesity and metabolic syndrome prevalence using fat mass index, body mass index and percentage body fat.
No full textBackgroundAccurate obesity classification is important so that appropriate intervention can be instituted to modify metabolic risk factors. Commonly utilized body mass index (BMI) and percentage body fat (PBF) are influenced by lean mass whereas fat mass index (FMI) measures only body fat. This study compares the prevalence of obesity and metabolic risk factors with FMI, BMI and PBF using DXA (dual-energy x-ray absorptiometry).Methods489 women randomly recruited from the electoral roll were stratified into 4 age groups; 40-49, 50-59, 60-69 and 70-79 years from 2000 to 2001. Clinical data and DXA body composition were obtained. Statistical analyses were performed using Medcalc v15 (Ostend, Belgium) with significance level at p = 0.05 (two-tailed).ResultsThere was higher prevalence of obesity using PBF compared to BMI and FMI (p0.05).ConclusionPBF classified more obesity than BMI and FMI because of its low pre-determined threshold. The greater difference with PBF compared to BMI and FMI from the 50-59 decade onwards can be attributed to age-related lean mass loss. BMI had the lowest sensitivity for obesity diagnosis. BMI under-classified obesity in the overweight category compared to FMI due to its inability to differentiate lean mass. However, there was no significant difference in the prevalence of metabolic risk factors between BMI and FMI-obesity categories indicating that fat location may influence metabolic dysregulation
DIFFERENCES IN SEGMENTAL FAT ACCUMULATION BY SEX AND ETHNICITY: AN INTERNATIONAL APPROACH
No full textJ. A. Wong, S. P. Shultz
Seattle University, Seattle, WA
Total excess fat on the body impacts obesity-related co-morbidity risk; however, the location of fat stores affects the severity of these health risks. While body composition may differ across sex and ethnicity, there has been little research on the relationship between these factors and fat accumulation patterns. Purpose: The purpose of this study was to examine segmental fat accumulation patterns by sex and ethnicity using international datasets. Methods: An amalgamated dataset of DXA-measured variables compiled segmental mass for bone mineral content, lean mass, and fat mass for each participant; percentage of segment fat (PSF) was calculated. A total of 30,587 adults (N=16,490 females) from 13 datasets were included in the study. An 8 (ethnicity) x 3 (segment) ANOVA was used to examine differences in regional fat mass and PSF for females; Arab datasets were female-only so a 7 (ethnicity) x 3 (segment) ANOVA compared the same variables in males. Results: All populations followed the same segmental fat mass accumulation in the ascending order (armsConclusion: Greater absolute and relative fat accumulation in the trunk could place European Caucasian females and most males (excluding Mexican and Black males) at a higher risk of visceral fat deposition and associated co-morbidities. Greater relative fat accumulation in the appendages may increase difficulty with activities that require moving mass
Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis
No full textNutrition during development affects risk of future cardiovascular disease. Relatively little is known about whether the amount and type of fat in the maternal diet affect vascular function in the offspring. To investigate this, pregnant and lactating rats were fed either 7%(w/w) or 21%(w/w) fat enriched in either18:2n-6, trans fatty acids, saturated fatty acids, or fish oil. Their offspring were fed 4%(w/w) soybean oil from weaning until day 77. Type and amount of maternal dietary fat altered acetylcholine (ACh)-mediated vaso-relaxation in offspring aortae and mesenteric arteries, contingent on sex. Amount, but not type, of maternal dietary fat altered phenylephrine (Pe)-induced vasoconstriction in these arteries. Maternal 21% fat diet decreased 20:4n-6 concentration in offspring aortae. We investigated the role of ?6 and ?5 desaturases, showing that their inhibition in aortae and mesenteric arteries reduced vasoconstriction, but not vaso-relaxation, and the synthesis of specific pro-constriction eicosanoids. Removal of the aortic endothelium did not alter the effect of inhibition of ?6 and ?5 desaturases on Pe-mediated vasoconstriction. Thus arterial smooth muscle 20:4n-6 biosynthesis de novo appears to be important for Pe-mediated vasoconstriction. Next we studied genes encoding these desaturases, finding that maternal 21% fat reduced Fads2 mRNA expression and increased Fads1 in offspring aortae, indicating dysregulation of 20:4n-6 biosynthesis. Methylation at CpG -394 bp 5' to the Fads2 transcription start site predicted its expression. This locus was hypermethylated in offspring of dams fed 21% fat. Pe treatment of aortae for 10 minutes increased Fads2, but not Fads1, mRNA expression (76%; P<0.05). This suggests that Fads2 may be an immediate early gene in the response of aortae to Pe. Thus both amount and type of maternal dietary fat induce altered regulation of vascular tone in offspring though differential effects on vaso-relaxation, and persistent changes in vasoconstriction via epigenetic processes controlling arterial polyunsaturated fatty acid biosynthesis
Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation
No full textScope
Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype.
Methods and results
Female C57Bl/6 mice were randomized to low or normal folate diets (0.4 or 2 mg folic acid/kg diet) prior to and during pregnancy and lactation. At 4 wk of age, offspring were randomized to high- or low-fat diets, weighed weekly and food intake assessed at 9 and 18 wk old. Adiposity was measured at 3 and 6 months. Plasma glucose and triacylglycerol (TAG) concentrations were measured at 6 months.
Maternal folate supply did not influence adult offspring body weight or adiposity. High-fat feeding post weaning increased body weight and adiposity at 3 and 6 months (p > 0.001). Maternal low folate lowered plasma glucose (p = 0.010) but increased plasma TAG (p = 0.048). High-fat feeding post weaning increased plasma glucose and TAG (p = 0.023, p = 0.049 respectively). Offspring from folate-depleted (but not folate-adequate) dams had 30% higher TAG concentration when fed the high-fat diet from weaning (p = 0.005 for interaction).
Conclusion
Inadequate maternal folate intake has long-term effects on offspring metabolism, manifested as increased circulating TAG, particularly in offspring with high-fat intake post weaning
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