21,090 research outputs found
Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus
No full textThe nuclear import of assembled spliceosomal subunits, the uridine rich small nuclear ribonucleoprotein particles U snRNPs , is mediated by a nuclear import receptor adaptor couple of importin amp; 946; Imp amp; 946; and snurportin1 SPN1 . In contrast to any other characterized active nuclear import, the Imp amp; 946; SPN1 U snRNP complex does not require RanGTP for the terminal release from the nuclear basket of the nuclear pore complex NPC . The crystal structure of Imp amp; 946; 127 876 in complex with the Imp amp; 946; binding IBB domain of SPN1 1 65 at 2.8 resolution reveals that Imp amp; 946; adopts an open conformation, which is unique for a functional Imp amp; 946; cargo complex, and rather surprisingly, it resembles the conformation of the Imp amp; 946; RanGTP complex. As binding of RanGTP to Imp amp; 946; usually triggers the release of import complexes from the NPC, we propose that by already mimicking a conformation similar to Imp amp; 946; RanGTP the independent dissociation of Imp amp; 946; SPN1 from the nuclear basket is energetically aide
Report on Meteorological Research March 1, 1935 (m-1)
No full textThe object of the report was to elucidate in detail the various features of the research program in meteorology being carried on at the Daniel Guggenheim Airship Institute in Akron, Ohio. Mr. L. J. Fangman, of the U.S. Weather Bureau, was collaborating with the author in carrying out work such as a study of autographic records of the various meteorological elements during frontal passages with a view to the possible prediction of the intensity of the accompanying disturbance as it may affect the operation of aircraft and a study of atmospheric gustiness with a view to finding the dependence between frequency end amplitude of velocity fluctuations and the vertical temperature and velocity gradients
Thermodynamic analysis of H1 nuclear import - Receptor tuning of importin beta/importin7
No full textThe nuclear import of H1 linker histones is mediated by a heterodimer of transport receptors, known as importin beta and importin7. Interestingly, both importins separately interact with H1, but only as a dimer they facilitate the translocation through the nuclear pore. We identified the H1 binding site of importin7, comprising two extended acidic loops near the C terminus of importin7. The analysis of the H1 import complex assembly by means of isothermal titration calorimetry revealed that the formation of a receptor heterodimer in vitro is an enthalpy-driven process, whereas subsequent binding of H1 to the heterodimer is entropy-driven. Furthermore, we show that the importin beta binding domain of importin7 plays a key role in the activation of importin7 by importin beta. This process is allosterically regulated by importin beta and accounts for a specific tuning of the activity of the importin beta center dot importin7 heterodimer. The results presented here provide new insights into cellular strategies to even energy balances in nuclear import and point toward a general regulation of importin beta-related nuclear import processes
(Fourth) Report on Meteorological Activities at the DGAI (8-1-36)(Weather Bureau Copy)
No full textThis report is on the investigations of frontal phenomena at the Daniel Guggenheim Airship Institute in Akron, Ohio from January 1, 1935 through August 1, 1936. The investigation was carried out with the cooperation of the U.S. Bureau of Aeronautics, the U.S. Weather Bureau, the California Institute of Technology, and the Guggenheim Airship Institute. Mr. R.C. Robinson of the Weather Bureau cooperated with the author in carrying out the investigation. The object of the investigation was to determine the intensity of the atmospheric disturbances (i.e. rapidity of wind shift and gustiness) accompanying the passage of cold fronts, along with a study of the characteristics of the air masses involved and other features which might affect the intensity of the disturbance. The report treated thirty cold fronts which passed the station during 1935 to 1936
Archives and Images as Repositories of Time, Language, and Forms from the Past: A Conversation with Daniel Eisenberg
No full textDaniel Akech
No full textabstract: Daniel was a little boy when the war came to his village. He witnessed people being shot and running for shelter. There was no food or water so he drank urine and ate tree leaves.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 24Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Daniel Emmett postcard
No full textPostcard of Daniel Emmett and his home in Mount Vernon, Ohio. Emmett is considered to be the author of the antebellum song "Dixie," written in 1859, which became the unofficial song of the Confederate soldiers during the American Civil War. He was born in Mount Vernon in 1815 and taught himself the fiddle, and later became associated with minstrel shows and helped to define that genre. Minstrel shows traveled around the United States, presenting skits and musical performances. Emmett also composed many other songs, including "Old Dan Tucker," "Turkey in the Straw," and "The Blue Tail Fly." He died in 1904
Daniel Jau Maper
No full textabstract: Daniel Jau Maper was herding cattle when Arabs attacked his village.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 27Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Daniel A. Ngor
No full textWhen Daniel was five years old Arab soldiers attacked his village.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age : 23Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Personal Papers (MS 80-0002)
No full textLetter from Mary T. Steyn of The Readers Digest to Daniel W. Kempner providing some information on the author of an article he was asking about
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