4,689 research outputs found
Elaine M. Alexander: 2023 Cook Prize Gold Medal Acceptance Speech
No full textAuthor Elaine M. Alexander gives an acceptance speech for Anglerfish: The Seadevil of the Deep, illustrated by Fiona Fogg (Candlewick)https://educate.bankstreet.edu/cook/1007/thumbnail.jp
Pseudomelanoma follow-up of a recurrent naevus with dermoscopy and reflectance confocal microscopy
No full textPseudomelanom
Kenneth M Alexander - Author and Artist
No full textI was born to Dennis and Kathleen Alexander in a single motor garage at 21 Limerick Road in Athlone. In those days, the midwife would do her rounds on a bicycle at the time when the stork was seen flying over the now-collapsed, missing going, gone forever Athlone Towers. Either that or she went to the foot of Table Mountain and placed a hollowed out pumpkin with a precision cut hole in one side. The monkey would come, stick his or her hand in the hole, grab some pips and in trying to pull its hand out in a fist, it gets stuck. The midwife then pounces on the helpless monkey, knocks it out with her case, and then stuffs "it" into that same black case and off she motors on her "dik" wheel bicycle to deliver the latest addition to an Athlone family. The monkey cries with relief when let out of the case. I have since moved on from that belief system. For some reason, the majority of the employers I worked for still believe that. In fact, far too many white people still do. To them we are monkeys and they pay us with peanuts
Case Report: melanoma and melanocytic nevus differentiation with reflectance confocal microscopy. [v1; ref status: indexed, http://f1000r.es/5mr]
No full textHistorically, melanoma has been typically diagnosed by naked-eye examination and confirmed with invasive biopsy. However, recently the use of reflectance confocal microscopy enables non-invasive bedside diagnosis of clinically equivocal lesions. We present a case in which reflectance confocal microscopy was used to evaluate two skin lesions in the same patient confirming the diagnosis of a melanoma and potentially avoiding invasive biopsy in the second benign melanocytic lesion. Clinicians should be aware of the availability of new non-invasive technologies that can aid in early diagnosis of malignant skin tumors and potentially reduce the number of benign lesion excisions
Alexander, the Crown Prince
No full textThe Life of Alexander by Plutarch and the Alexander Romance by Ps.-Callisthenes are the only two sources that deal with Alexander’s birth, childhood and youth. Both works deliver a large number of anectodes: but only in the case of Plutarch’s biography do these anecdotes maintain a firm connection with reality. In the Alexander Romance, the author offers the reader a story full of plot twists. Alexander’s youth ended abruptly in the autumn of 336, when his father Philip II was murdered in Aigai, during the ceremonies organized to celebrate the wedding between Cleopatra, Philip’s daughter and Alexander’s sister, and the king of Epirus, Alexander called Molossos: the crown prince became king in a sudden and most unexpected way
Odoardo Fialetti (1573-c.1638): the interrelation of Venetian art and anatomy, and his importance in England
No full textBolognese artist Odoardo Fialetti (1573 – c.1638) is a fascinating figure upon which curiously little work has been done. Though he is a rarely discussed pupil of Tintoretto, Fialetti’s oeuvre is vast (some 55 known paintings and approximately 450 prints) and incredibly diverse. His work encompasses religious subjects, portraits, books on drawing and sport, maps, and illustration for treatises on city defences, literary texts, and anatomy. His work was influential for several hundred years after his death, not only in Venice and northern Italy, but also in France where his designs were used as decoration on faïence produced at Nevers, and England, where his paintings were much admired at court. Fialetti’s close association with Sir Henry Wotton, and the careful copy of his drawing book made by Alexander Browne in the mid-seventeenth century, attest to his impact on the formation of an Italianate sensibility in the appreciation of the visual arts in Early Modern England. In the realm of science, Fialetti’s influence can be deduced from his drawings of curiously animated cadavers in detailed landscapes to those of future generations of anatomists and illustrators throughout Europe. Because of the diverse associations and projects throughout his career, the study of Fialetti is inherently interdisciplinary, encompassing the history of art, history of science and history of the Venetian book trade, as well as crossing geographical boundaries in linking Venetian art and English tastes of the late renaissance and early baroque. Through examination of his extant oeuvre, as well as discussion of lost work, I aim to recognise Fialetti’s status as an artist responding to contemporary artistic debates (disegno versus colorito), a changing cultural climate and the burgeoning importance of the printed medium
Convolutional Neural Network Approach to Classify Skin Lesions Using Reflectance Confocal Microscopy
No full textWe propose an approach based on a convolutional neural network to classify skin lesions using the reflectance confocal microscopy (RCM) mosaics. Skin cancers are the most common type of cancers and a correct, early diagnosis significantly lowers both morbidity and mortality. RCM is an in-vivo non-invasive screening tool that produces virtual biopsies of skin lesions but its proficient and safe use requires hard to obtain expertise. Therefore, it may be useful to have an additional tool to aid diagnosis. The proposed network is based on the ResNet architecture. The dataset consists of 429 RCM mosaics and is divided into 3 classes: melanoma, basal cell carcinoma, and benign naevi with the ground-truth confirmed by a histopathological examination. The test set classification accuracy was 87%, higher than the accuracy achieved by medical, confocal users. The results show that the proposed classification system can be a useful tool to aid in early, noninvasive melanoma detection
Hedging with Stochastic and Local Volatility
No full textWe derive the local volatility hedge ratios that are consistent with a stochastic instantaneous volatility and show that this ‘stochastic local volatility’ model is equivalent to the market model for implied volatilities. We also show that a common feature of all Markovian single factor stochastic volatility models, (log)normal mixture option pricing models and ‘sticky delta’ models is that they predict incorrect dynamics for implied volatility. As a result they over-hedge the Black-Scholes model in the presence of a market skew and this explains the poor delta hedging performance of these models reported in the literature. Whilst the traditional ‘sticky tree’ local volatility models do not possess this unfortunate property, they cannot be used for pricing without exogenous and ad hoc smoothing of results. However the stochastic local volatility framework allows one to extend a good pricing model into a good hedging model. The theoretical results are supported by an empirical analysis of the hedging performance of seven models, each with different volatility characteristics, on the SP500 index skew.Local volatility, stochastic volatility, implied volatility, hedging, dynamic delta hedging, volatility dymamics
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