1,721,032 research outputs found
Evaluation of [68Ga]Ga-PSMA-11 PET/CT in the early therapeutic assessment of metastatic castration-resistant prostate cancer patients treated by first-line novel hormonal agents
No full textMonitoring treatment response in metastatic castration-resistant prostate cancer (mCRPC) remains a major challenge. Conventional strategies, based on PSA levels and standard imaging, often provide delayed or ambiguous information and fail to capture tumor heterogeneity, leading to late identification of non-responders and potentially worse outcomes. This thesis investigated [⁶⁸Ga]Ga-PSMA-11 PET/CT as a dynamic biomarker for early therapy response assessment in mCRPC patients initiating androgen receptor pathway inhibitors (ARPIs), with the aim of determining whether early imaging changes could predict long-term clinical outcomes.
Across three studies, we explored the feasibility, prognostic value, and biological interpretation of early sequential [⁶⁸Ga]Ga-PSMA-11 PET/CT. The first study showed that global tumor response at 4 weeks was strongly associated with the 12-week response, highlighting the potential of early imaging to detect early treatment resistance, while cautioning against misinterpretation due to a possible flare phenomenon. The second study showed that while this flare was relatively common, affecting about one in four patients, it was generally of low magnitude. The third study demonstrated that interlesional heterogeneity, with progression in only a subset of lesions despite global stability or favorable response, was associated with early treatment failure and poor survival, underscoring the prognostic and potentially predictive value of lesion-level assessment using [⁶⁸Ga]Ga-PSMA-11 PET/CT.
Overall, these findings support the clinical relevance of early imaging and interlesional heterogeneity analysis, warranting further investigation to refine the prediction of treatment efficacy and failure in mCRPC. This approach could identify high-risk patients overlooked by standard criteria, enabling earlier treatment adaptation and potentially improving outcomes. This work establishes the foundation for a more dynamic, personalized, and biologically informed model to mCRPC management
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Imagerie de l'int\ue9grine \u3b1v\u3b23 par tomographie \ue0 \ue9mission de positons au [18F]FPRGD2 combin\ue9e \ue0 une tomodensitom\ue9trie
No full textImagerie de l'intégrine αvβ3 par tomographie à émission de positons au [18F]FPRGD2 combinée à une tomodensitométrie
No full textLES RADIOTRACEURS AUTRES QUE LE PSMA-LIGAND POUR L’IMAGERIE TEP DU CANCER DE PROSTATE
Get PDFLa TEP/TDM ciblant l’antigène membranaire spécifique de la prostate (PSMA) est la technique d’imagerie de choix du cancer de prostate, elle a cependant des limites. L’objectif de cette revue est de présenter les radiotraceurs autres que ceux ciblant le PSMA pour l’imagerie TEP du cancer de prostate
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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