503 research outputs found
DEEP - A tool for differential expression effector prediction
No full textHigh-throughput methods for measuring transcript abundance, like SAGE or microarrays, are widely used for determining differences in gene expression between different tissue types, dignities (normal/malignant) or time points. Further analysis of such data frequently aims at the identification of gene interaction networks that form the causal basis for the observed properties of the systems under examination. To this end, it is usually not sufficient to rely on the measured gene expression levels alone; rather, additional biological knowledge has to be taken into account in order to generate useful hypotheses about the molecular mechanism leading to the realization of a certain phenotype. We present a method that combines gene expression data with biological expert knowledge on molecular interaction networks, as described by the TRANSPATH(1) database on signal transduction, to predict additional - and not necessarily differentially expressed - genes or gene products which might participate in processes specific for either of the examined tissues or conditions. In a first step, significance values for over-expression in tissue/condition A or B are assigned to all genes in the expression data set. Genes with a significance value exceeding a certain threshold are used as starting points for the reconstruction of a graph with signaling components as nodes and signaling events as edges. In a subsequent graph traversal process, again starting from the previously identified differentially expressed genes, all encountered nodes 'inherit' all their starting nodes' significance values. In a final step, the graph is visualized, the nodes being colored according to a weighted average of their inherited significance values. Each node's, or sub-network's, predominant color, ranging from green (significant for tissue/condition A) over yellow (not significant for either tissue/condition) to red (significant for tissue/condition B), thus gives an immediate visual clue on which molecules - differentially expressed or not - may play pivotal roles in the tissues or conditions under examination. The described method has been implemented in Java as a client/server application and a web interface called DEEP (Differential Expression Effector Prediction). The client, which features an easy-to-use graphical interface, can freely be downloaded from the following URL: http://deep.bioinf.med.uni-goettingen.de
Engelgemeinschaft im irdischen Gottesdienst : Studien zu Texten aus Qumran und dem Neuen Testament
No full textThe motif of liturgical communion with angels appears in early Jewish and New Testament texts. Michael R. Jost offers the first exegetical analysis of all relevant passages from the Dead Sea Scrolls and the New Testament and places them within traditio-historical developments from the Hebrew Bible to rabbinical and patristic texts. By giving special consideration to the respective performances of liturgical texts, the author reconstructs each groups' experience of angelic communion. In his analysis of the liturgical communion of the yaḥad, Jost presents new insights not only for Qumran researchbut also for New Testament scholarship and the understanding of the early Christian communities and communal liturgies
Memorial for Jost Delbrück
No full textOn November 6, 2020, Jost Delbruck--the renowned scholar, author, and teacher of public international law who spent almost his whole academic life commuting between the Law School of Kiel University in Germany and Indiana University Maurer School of Law--passed away, only a few days after his 85th birthday. Hundreds of friends, colleagues, pupils, and former students on both sides of the Atlantic mourn for an extraordinary, brilliant, and inspiring person. His close ties to Kiel and Bloomington alike influenced the intellectual life of both Law Schools. The impact of his work remains visible to this day
Another remark on a result of Ding-Jost-Li-Wang
No full textLet be a compact Riemann surface, be a positive smooth function
on . It is well known the functional achieves its minimum under
Ding-Jost-Li-Wang condition. This result was generalized to nonnegative by
Yang and the author. Later, Sun and Zhu (arXiv:2012.12840) showed
Ding-Jost-Li-Wang condition is also sufficient for achieves its minimum
when changes sign, which was reproved later by Wang and Yang (J. Funct.
Anal. 282: Paper No. 109449, 2022) and Li and Xu (Calc. Var. 61: Paper No. 143,
2022) respectively using flow approach. The aim of this note is to give a new
proof of Sun and Zhu's result. Our proof is based on the variational method and
the maximum principle.Comment: 13 pages. To appear on Proc. AM
Jost function method on a Lagrange mesh
No full textIn a new formalism of the Jost function method, the coupled first-order differential equations are solved on a Lagrange mesh. To this end, we modify the original definition of the expansion in the Lagrange basis by adding an inhomogeneous term. Bound and scattering states within a simple potential model are obtained with reasonable accuracy. Further, we apply the present formalism to solve scattering states of the 4He+n system in order to examine the applicability to a realistic nuclear problem. © The Author(s) 2013.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Microbial extracellular polymeric substances in the environment, technology and medicine
No full textMicrobial biofilms exhibit a self-produced matrix of extracellular polymeric substances (EPS), including polysaccharides, proteins, extracellular DNA and lipids. EPS promote interactions of the biofilm with other cells and sorption of organics, metals and chemical pollutants, and they facilitate cell adhesion at interfaces and ensure matrix cohesion. EPS have roles in various natural environments, such as soils, sediments and marine habitats. In addition, EPS are relevant in technical environments, such as wastewater and drinking water treatment facilities, and water distribution systems, and they contribute to biofouling and microbially influenced corrosion. In medicine, EPS protect pathogens within the biofilm against the host immune system and antimicrobials, and emerging evidence suggests that EPS can represent potential virulence factors. By contrast, EPS yield a wide range of valuable products that include their role in self-repairing concrete. In this Review, we aim to explore EPS as a functional unit of biofilms in the environment, in technology and in medicine.</p
Jost Wilhelm Ernst Delbrück
No full textJost W. E. Delbrück was born in the town of Pyrzyce, in northwest Poland, on November 3rd, 1935. After WW II, he received his secondary education in Germany, before studying law and political science at Kiel University. He came to America in 1959 to study at both the Indiana University School of Law and the I.U. Department of Political Science. This culminated in his receiving his Masters of Law in 1960. He then returned to Germany and completed his examinations in law. In 1963, he returned to I.U. as a research fellow in the methodology of law, political theory, and sociology.
Over the next 50 years, Delbrück became a renowned scholar, author and teacher of international law and German constitutional law. He was awarded his doctorate from Kiel University in 1964 and continued his post-doctoral studies at the The Hague Academy of International Law. In 1972, he became a professor of Law at the Georg-Ausust University at Göttingen and Director of its Institute of Political Science and Theory of the State. He served as the Dean of the Faculty of Laws at the University of Kiel from 1979 to 1981, as well as serving as President and Rector of the University from 1985 to 1989.
In addition to his academic career, Delbrück served as a Judge, on the Administrative Court of Appeal Schleswig-Holstein and was a member of the Permanent Court of Arbitration in The Hague. From 1997 until 2001, he served as President of the German Association of International Law. He also served as a delegate of the Federal Republic of Germany to the UN Human Rights Committee and is a member of the funding commission of the German Society for Peace and Conflict Research.
In 1991, he was appointed to the faculty of the Indiana University School of Law, teaching courses in international and European Community law and serving as a Resident Fellow of the Indiana University Institute for Advanced Study. Delbrück received an honorary doctorate from the Faculty of Humanities, Social Science, and Education of the Ott von Guericke University in 2006 and was inducted into the Indiana University School of Law Academy of Law Alumni Fellows in 1992.
Jost Delbrück died in Kiel, Germany, in November 2020.https://www.repository.law.indiana.edu/notablealumni/1103/thumbnail.jp
Jost Wilhelm Ernst Delbrück
No full textJost W. E. Delbrück was born in the town of Pyrzyce, in northwest Poland, on November 3rd, 1935. After WW II, he received his secondary education in Germany, before studying law and political science at Kiel University. He came to America in 1959 to study at both the Indiana University School of Law and the I.U. Department of Political Science. This culminated in his receiving his Masters of Law in 1960. He then returned to Germany and completed his examinations in law. In 1963, he returned to I.U. as a research fellow in the methodology of law, political theory, and sociology.
Over the next 50 years, Delbrück became a renowned scholar, author and teacher of international law and German constitutional law. He was awarded his doctorate from Kiel University in 1964 and continued his post-doctoral studies at the The Hague Academy of International Law. In 1972, he became a professor of Law at the Georg-Ausust University at Göttingen and Director of its Institute of Political Science and Theory of the State. He served as the Dean of the Faculty of Laws at the University of Kiel from 1979 to 1981, as well as serving as President and Rector of the University from 1985 to 1989.
In addition to his academic career, Delbrück served as a Judge, on the Administrative Court of Appeal Schleswig-Holstein and was a member of the Permanent Court of Arbitration in The Hague. From 1997 until 2001, he served as President of the German Association of International Law. He also served as a delegate of the Federal Republic of Germany to the UN Human Rights Committee and is a member of the funding commission of the German Society for Peace and Conflict Research.
In 1991, he was appointed to the faculty of the Indiana University School of Law, teaching courses in international and European Community law and serving as a Resident Fellow of the Indiana University Institute for Advanced Study. Delbrück received an honorary doctorate from the Faculty of Humanities, Social Science, and Education of the Ott von Guericke University in 2006 and was inducted into the Indiana University School of Law Academy of Law Alumni Fellows in 1992.
Jost Delbrück died in Kiel, Germany, in November 2020.https://www.repository.law.indiana.edu/notablealumni/1103/thumbnail.jp
Zheng He's Maritime Voyages (1405-1433) and China's Relations with the Indian Ocean World: A Multilingual Bibliography.
No full textA&HCIBOOK REVIEW219-2207
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