4,685 research outputs found
Stylos kai edraiōma tēs ekklēsias, sive, Dissertatio de iustificatione hominis
No full textquam ... sub praesidio ... Ioh. Henrici Heideggeri ... placido eruditorum examini subiicit Andreas Steinerus, Vitod. author & respondens, ad diem Octobris loco horisque solitisDiss. Hohe Schule Zürich, 167
Effects of sevoflurane anesthesia on cognitive function and cholinergic signaling
No full textIn recent years, concerns have been raised regarding the potential negative impact of anesthetic drugs in postoperative cognitive dysfunction. This thesis is an attempt to contribute to the understanding of the underlying mechanisms. Previous animal studies have suggested that volatile anesthetics can cause long-lasting cognitive alterations in various settings. Based on the strong association between cholinergic function and cognitive performance, we have focused our studies on the long-term effects of volatile anesthetics on cholinergic neurotransmission.By using a combination of laboratory animal experiments and molecular biology techniques in cultured cells, we have described effects of sevoflurane anesthesia on cognitive function and cholinergic signaling. Our studies on spontaneous exploratory behavior, anxiety, object memory and analyses of behavioral organization in mice show that for some aspects of cognitive performance sevoflurane can cause long-lasting effects, while other aspects are unaltered by anesthesia. We have shown that age and preexisting cholinergic dysfunction are factors that influence the results. A normal cholinergic system, as represented by young wild type mice, seems to protect from behavioral alterations after anesthesia.Our results suggest that sevoflurane causes a sustained attenuation in acetylcholine-induced phosphorylation of important intracellular kinases. We have linked our findings to signaling via muscarinic acetylcholine receptors, and we have also demonstrated that the effect of sevoflurane is not likely exerted by reducing the receptor population on the cell surface, nor by altering the total amount of receptor protein available for ligand binding.The overall conclusion from the results of this thesis is that under certain experimental conditions, sevoflurane induces long-lasting alterations both in animal behavior and in cellular signaling.List of scientific papersI. Wiklund A, Granon S, Cloëz-Tayarani I, Faure P, le Sourd AM, Sundman E, Changeux JP, Eriksson LI. Sevoflurane anesthesia alters exploratory and anxiety-like behavior in mice lacking the beta2 nicotinic acetylcholine receptor subunit. Anesthesiology. 2008 Nov;109(5):790-8. https://doi.org/10.1097/ALN.0b013e31818a379a II. Wiklund A, Granon S, Faure P, Sundman E, Changeux JP, Eriksson LI. Object memory in young and aged mice after sevoflurane anaesthesia. Neuroreport. 2009 Oct 28;20(16):1419-23. https://doi.org/10.1097/WNR.0b013e328330cd2b III. Wiklund A, Gustavsson D, Ebberyd A, Sundman E, Schulte G, Jonsson Fagerlund M, Eriksson L.I. Prolonged attenuation of acetylcholine-induced phosphorylation of ERK 1/2 in PC12 cells following sevoflurane exposure. [Submitted]IV. Wiklund A, Gustavsson D, Ebberyd A, Mkrtchian S, Jonsson Fagerlund M, Eriksson L.I, Schulte G. Muscarinic acetylcholine receptor gene expression profile in PC12 cells following sevoflurane exposure. [Manuscript]</p
Author: Andreas Johannis Prytz
No full textAn edition of the consecration sermons in Gothenburg Cathedral 1633 by Superintendent Andreas Johannis Prytz, with introductory comments. The first sermon deals with the need for Church buildings, the second with the consecration of a new Church
We must combine conservation of nature with benefits to society. Interview by Gaby Allheilig with Andreas Heinimann on IPBES' Global Assessment Report on Biodiversity and Ecosystem Services
No full textOn 6 May 2019, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) presented its report on the state of biodiversity and ecosystem services worldwide. The first such assessment since 2005, it concludes that biodiversity and ecosystem loss has reached the point where it threatens human well-being. The researchers involved recommend several urgent measures to political decision-makers. Andreas Heinimann of CDE was the one Swiss scientist who worked as a lead author on a chapter of the report
To athanaton tēs psychēs, sive, Dissertatio de animae immortalitate, ex naturae & sanae rationis lumine demonstrata
No full textquam ... sub praesidio ... Iohannis Lavateri ... publicae ac placidae disquisitioni submittit Andreas Steinerus, Vitod. author & respondens ...Dedikation an Johannes Lavater, Jacob Meyer, Joh. Jacob Schaedler und Jacob Hegner auf dem Titelbl. versoDiss. Hohe Schule Zürich, 167
Family Virtues and Social Critique: Andreas Latzko’s Anti-War Prose (1917-1918)
No full textBetween 1917 and 1918, the Austro-Hungarian author Andreas Latzko (1876-1943) wrote three separate publications against the Great War: Menschen im Krieg (1917), Friedensgericht (1918), and Der letzte Mann (published 1919). Literary historians tend to bypass these works, and the few who note them chiefly focus on the best-selling novella cycle Menschen im Krieg (1917). It is usually presented as an example of expressionist political prose, or as a mixture of social satire and aesthetic shock-tactics that chiefly remains indebted to realist traditions, albeit with occasional incursions into expressionistic styles..
Short laws for finite groups and residual finiteness growth
No full text We prove that for every n ∈ N n \in \mathbb {N} and δ > 0 \delta >0 there exists a word w n ∈ F 2 w_n \in F_2 of length O ( n 2 / 3 log ( n ) 3 + δ ) O(n^{2/3} \log (n)^{3+\delta }) which is a law for every finite group of order at most n n . This improves upon the main result of Andreas Thom [Israel J. Math. 219 (2017), pp. 469–478] by the second named author. As an application we prove a new lower bound on the residual finiteness growth of non-abelian free groups. </p
Value quantification
No full textThis chapter explores the concept and practice of value quantification, emphasizing its crucial role in effectively communicating product offerings in industrial markets. Rather than relying solely on product characteristics, successful sales strategies involve translating unique selling points into quantifiable customer-specific economic value. The chapter synthesizes existing marketing and pricing literature, presenting a comprehensive model that categorizes benefits and sacrifices into quantitative and qualitative dimensions relevant to both B2B and B2C contexts. The author delineates a systematic approach for quantifying customer value, highlighting practical methodologies such as economic value analysis and conjoint analysis. Furthermore, the chapter underscores the managerial implications of value quantification, including enhanced pricing strategies, improved negotiation positions, reduced discounting, and performance-based pricing opportunities. Through detailed frameworks and real-world examples, the chapter provides actionable insights for effectively leveraging quantified value to gain competitive advantage and drive customer purchasing decisions
Sammlung von Merckwürdigkeiten der Natur und Alterthümern des Erdbodens, welche petrificirte Cörper enthält / aufgewiesen und beschrieben von Georg Wolffgang Knorr
No full textVorlageform des Erscheinungsvermerks: Nürnberg, zu finden bey dem Author. Gedruckt bey Andreas Bieling
Sammlung von Merckwürdigkeiten der Natur und Alterthümern des Erdbodens, welche petrificirte Cörper enthält
No full textaufgewiesen und beschrieben von Georg Wolffgang KnorrVorlageform des Erscheinungsvermerks: Nürnberg, zu finden bey dem Author. Gedruckt bey Andreas Bieling
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