1,720,956 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Undersökning av interaktionen mellan LRH-1 och ERβ
No full textÄggstockarna är komplexa och dynamiska organ där ägglossning är en av de viktigaste funktionerna. Ägglossningen regleras av flera olika hormoner, varav en är östrogen i form av östradiol (E2). E2 är även ligand för flera olika receptorer, bland annat den nukleära östrogenreceptorn β som aktiveras vid interaktion med E2. Detta resulterar i en translokation av proteinet till cellkärnan där det binder till specifika DNA-motif som kallas östrogenrespons-element (ERE). I sin tur reglerar detta gener som är viktiga för välfungerade äggstockar och ägglossning. En tidigare studie har funnit en potentiell interaktion mellan ERβ och leverreceptor-homolog 1 (LRH-1) genom analys av ERβs cistrome. Likt ERβ är LHR-1 en nukleär receptor som genom att binda till DNA-motiv reglerar associerade gener. Denna studie visade att nästan 45% av alla sekvenser bundna av ERβs också innehöll motivet NR5A, vilket är den sekvens som LRH-1 binder till. Dessutom fann studien att regioner som bands av båda proteinerna vanligtvis inkluderade båda motiven, eller endast NR5A. Därmed kunde en slutsats om att LRH-1 och ERβ till stor del har ett gemensamt cistrom dras, och föreslagna interaktionsmekanismer var antingen rekrytering av ERβ genom LRH-1 eller samtidig eller kompetitiv binding vid gemensamma regioner. Syftet med detta projekt var att fördjupa förståelsen för “crosstalk” mellan ERβ och LRH-1 genom att först konfirmera gen- och proteinuttrycket av dessa i olika musvävnader med hjälp av qPCR och western blot. Sedan genomfördes en analys av LRH-1s kromatininteraktioner i både äggstock och lever via kromatinimmunoprecipitering (ChIP). Det konstaterades att genuttrycket för Esr2 var högt i äggstock, lågt i tjocktarm samt lunga och nära noll i tunntarm, mjälte och lever. Uttrycket av Nr5a2 var också högst i äggstocken. följt av lever och tjocktarm. Visst uttryck kunde påvisas i tunntarm men inget varken mjälte eller lunga. Detta styrktes av resultaten från analysen av proteinuttrycket som visade på uttryck av ERβ i äggstock och av LRH-1 i äggstock och lever. Inga slutsatser kunde dras kring interaktionerna mellan LRH-1 och kromatin då regioner där LRH-1 förväntades binda inte var anrikade i jämförelse med negativa kontrollregioner, och experimenten var därmed inte lyckade.The ovaries are complex and dynamic organs where ovulation is one of the most important events. The ovulatory process is regulated by numerous hormones, one of which is estrogen in the form of estradiol (E2). E2 is also a ligand for different receptors, including nuclear estrogen receptor β (ERβ, Esr2), that is activated upon interaction with E2. This results in translocation of the protein into the nucleus where it binds to DNA motifs called estrogen response elements (ERE). In turn, this regulates genes that are important for a well functioning ovary and ovulation. A previous study found a potential interaction between ERβ and liver receptor homolog 1 (LRH-1, Nr5a2) through analysis of the ERβ cistrome. Similarly to ERβ, LRH-1 is a nuclear receptor and binds to DNA motifs to regulate associated genes. It was revealed that almost 45% of sequences bound by ERβ also contained a motif, NR5A, which is the target sequence for LRH-1. Additionally, it was found that sites bound by both proteins commonly contained either both motifs or only NR5A. It was concluded that LRH-1 and ERβ share a large extent of their cistrome, and proposed interactions were ERβ-recruitment by LRH-1 or simultaneous or competitive binding at shared sites. The aim of this project was to deepen the understanding of the crosstalk between ERβ and LRH-1 by first confirming the gene and protein expression in various tissues from mice using qPCR and western blot. Then, an analysis of the chromatin interactions of LRH-1 in both ovary and liver was performed using chromatin immunoprecipitation (ChIP) experiments. It was found that gene expression of Esr2 was predominant in the ovary, low in colon and lung, and close to none in small intestine, spleen and liver. Expression of Nr5a2 was highest in the ovary followed by the liver and colon. Some expression was exhibited in the small intestine and close to none in the spleen and lung. This was supported by the protein expression analysis that indicated presence of ERβ in the ovary, and LRH-1 in the ovary and liver. No conclusions can be drawn about the LHR-1 chromatin interactions as expected target regions showed no enrichment in comparison to negative control regions, and the experiments were therefore unsuccessful.
Undersökning av interaktionen mellan LRH-1 och ERβ
No full textÄggstockarna är komplexa och dynamiska organ där ägglossning är en av de viktigaste funktionerna. Ägglossningen regleras av flera olika hormoner, varav en är östrogen i form av östradiol (E2). E2 är även ligand för flera olika receptorer, bland annat den nukleära östrogenreceptorn β som aktiveras vid interaktion med E2. Detta resulterar i en translokation av proteinet till cellkärnan där det binder till specifika DNA-motif som kallas östrogenrespons-element (ERE). I sin tur reglerar detta gener som är viktiga för välfungerade äggstockar och ägglossning. En tidigare studie har funnit en potentiell interaktion mellan ERβ och leverreceptor-homolog 1 (LRH-1) genom analys av ERβs cistrome. Likt ERβ är LHR-1 en nukleär receptor som genom att binda till DNA-motiv reglerar associerade gener. Denna studie visade att nästan 45% av alla sekvenser bundna av ERβs också innehöll motivet NR5A, vilket är den sekvens som LRH-1 binder till. Dessutom fann studien att regioner som bands av båda proteinerna vanligtvis inkluderade båda motiven, eller endast NR5A. Därmed kunde en slutsats om att LRH-1 och ERβ till stor del har ett gemensamt cistrom dras, och föreslagna interaktionsmekanismer var antingen rekrytering av ERβ genom LRH-1 eller samtidig eller kompetitiv binding vid gemensamma regioner. Syftet med detta projekt var att fördjupa förståelsen för “crosstalk” mellan ERβ och LRH-1 genom att först konfirmera gen- och proteinuttrycket av dessa i olika musvävnader med hjälp av qPCR och western blot. Sedan genomfördes en analys av LRH-1s kromatininteraktioner i både äggstock och lever via kromatinimmunoprecipitering (ChIP). Det konstaterades att genuttrycket för Esr2 var högt i äggstock, lågt i tjocktarm samt lunga och nära noll i tunntarm, mjälte och lever. Uttrycket av Nr5a2 var också högst i äggstocken. följt av lever och tjocktarm. Visst uttryck kunde påvisas i tunntarm men inget varken mjälte eller lunga. Detta styrktes av resultaten från analysen av proteinuttrycket som visade på uttryck av ERβ i äggstock och av LRH-1 i äggstock och lever. Inga slutsatser kunde dras kring interaktionerna mellan LRH-1 och kromatin då regioner där LRH-1 förväntades binda inte var anrikade i jämförelse med negativa kontrollregioner, och experimenten var därmed inte lyckade.The ovaries are complex and dynamic organs where ovulation is one of the most important events. The ovulatory process is regulated by numerous hormones, one of which is estrogen in the form of estradiol (E2). E2 is also a ligand for different receptors, including nuclear estrogen receptor β (ERβ, Esr2), that is activated upon interaction with E2. This results in translocation of the protein into the nucleus where it binds to DNA motifs called estrogen response elements (ERE). In turn, this regulates genes that are important for a well functioning ovary and ovulation. A previous study found a potential interaction between ERβ and liver receptor homolog 1 (LRH-1, Nr5a2) through analysis of the ERβ cistrome. Similarly to ERβ, LRH-1 is a nuclear receptor and binds to DNA motifs to regulate associated genes. It was revealed that almost 45% of sequences bound by ERβ also contained a motif, NR5A, which is the target sequence for LRH-1. Additionally, it was found that sites bound by both proteins commonly contained either both motifs or only NR5A. It was concluded that LRH-1 and ERβ share a large extent of their cistrome, and proposed interactions were ERβ-recruitment by LRH-1 or simultaneous or competitive binding at shared sites. The aim of this project was to deepen the understanding of the crosstalk between ERβ and LRH-1 by first confirming the gene and protein expression in various tissues from mice using qPCR and western blot. Then, an analysis of the chromatin interactions of LRH-1 in both ovary and liver was performed using chromatin immunoprecipitation (ChIP) experiments. It was found that gene expression of Esr2 was predominant in the ovary, low in colon and lung, and close to none in small intestine, spleen and liver. Expression of Nr5a2 was highest in the ovary followed by the liver and colon. Some expression was exhibited in the small intestine and close to none in the spleen and lung. This was supported by the protein expression analysis that indicated presence of ERβ in the ovary, and LRH-1 in the ovary and liver. No conclusions can be drawn about the LHR-1 chromatin interactions as expected target regions showed no enrichment in comparison to negative control regions, and the experiments were therefore unsuccessful.
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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