1,721,012 research outputs found
Clin Liver Dis (Hoboken)
Full text linkU2G PS000658/PS/NCHHSTP CDC HHS/United States2018-08-16T00:00:00Z30123492PMC6094390vault:3071
Recommended from our members
Unveiling the Veil: Racial Disparities and Liver Transplantation Barriers Experience from the United States Southwestern Region Center
No full textBackground: Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, yet disparities in access and outcomes persist, particularly among racial and ethnic minorities. This study aims to investigate barriers encountered by LT candidates at different stages and to assess racial disparities in referral, evaluation, listing, and post-transplant outcomes.Methods: A retrospective cohort study was conducted from January 1, 2012, to December 31, 2022, at Banner University Medical Center-Phoenix. Adult LT-referred patients were analyzed for demographic and clinical variables, including race, body mass index (BMI), primary disease, Model for End-Stage Liver Disease (MELD) score, and post-transplant outcomes. Barriers were categorized into social, financial, and clinical factors. Statistical analyses included comparative tests, competing-risk regression, and multivariable Cox proportional hazards analysis.
Results: Among 2,877 referrals, Native Americans accounted for 8.8%, with disparities observed in evaluation (39%) and listing (53%) compared to non-Hispanic whites (51% and 64%, respectively). Financial issues were prominent barriers for Native Americans (15.5%) and Hispanics (19.81%). Waitlist mortality was significantly higher for Native Americans (SHR: 5.26, p=0.005) and Hispanics (SHR: 2.92, p=0.017) compared to non-Hispanic whites. Graft survival did not significantly differ by race.
Conclusion: This study underscores persistent racial disparities and barriers in LT access and outcomes, particularly among Native American and Hispanic populations. Financial issues and waitlist mortality disproportionately affect minority groups. Efforts to address these disparities should focus on improving access to evaluation and addressing social determinants of health. Further research is needed to explore underlying factors contributing to these disparities and to implement targeted interventions to ensure equitable access to LT for all patients.Release after 06/19/202
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Watch out for the Saurkraut: Weissella confusa endocarditis in a liver transplant candidate
No full textContent available: Audio Recordin
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct-Acting Antiviral-Experienced Hepatitis C Virus Patients: A Systematic Review and Meta-Analysis
No full text: About 5% of chronic hepatitis C (CHC) patients experienced treatment failure with direct-acting antiviral (DAA) treatment. The global data on the practice and treatment outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) in DAA-experienced CHC patients remains sparse. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of SOF/VEL/VOX as a salvage treatment in DAA-experienced CHC patients. We searched five electronic databases from inception to 31 January 2023. The study outcomes were SVR12 and treatment-related adverse effects, with subgroup analysis performed based on genotype, cirrhosis, HCC, prior SOF/VEL exposure, and region. We identified and analyzed data from 24 studies (2877 DAA-experienced CHC patients); 17.2% had prior SOF/VEL exposure, 25% received ribavirin with SOF/VEL/VOX, and 42% had pre-treatment resistance-associated substitution (RAS) testing performed. Eastern Mediterranean had a higher pooled SVR12 than the America and Europe regions (p < 0.05). Predictors of SOF/VEL/VOX failure were genotype 3, active HCC, baseline cirrhosis, and prior SOF/VEL. Baseline RAS mutation and ribavirin supplementation were not associated with higher SVR12. Treatment discontinuation because of drug-related adverse events was uncommon (10 studies, 0.2%). In summary, SOF/VEL/VOX is efficacious and safe for retreatment in DAA-experienced CHC patients, even with RAS mutation. Our findings support SOF/VEL/VOX as a first-line rescue treatment for DAA-experienced CHC patients
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
