1,799 research outputs found
Meeting with the Hebrew author Elias Hurwitz
No full textWhite paper; handpainted; on the reverse of Luftwaffe uniform pattern. Digitized posters are related to the activities of Jewish displaced persons drawn from the Records of Displaced Persons Camps and Centers in Germany (RG 294.2) Italy (RG 294.3) and Austria (RG 294.4) held by YIVO Archives. Please consult the historical note for those record groups for further information.Digital ImageDigital finding aid available
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
No full textLigation of the cell-surface Fas molecule by its ligand (Fas-L) or agonistic anti-Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis. In some leukemia cell lines, cytotoxic drugs induce expression of Fas-L, which may contribute to cell killing through the ligation of Fas. The involvement of Fas, Fas-L, and caspase 8 was studied in the killing of B-cell chronic lymphocytic leukemia (B-CLL) cells by chlorambucil, fludarabine, or gamma radiation. Spontaneous apoptosis was observed at 24-hour incubation, with additional apoptosis induced by each of the cytotoxic treatments. Although Fas mRNA expression was elevated after exposure to chlorambucil, fludarabine, or gamma radiation, Fas protein levels only increased after irradiation. Therefore, Fas expression may be regulated by multiple mechanisms that allow the translation of Fas mRNA only in response to restricted cytotoxic stimuli. None of the cytotoxic stimuli studied here induced Fas-L expression. An agonistic anti-Fas monoclonal antibody (CH-11) did not significantly augment apoptosis induction by any of the death stimuli. A Fas-blocking antibody (ZB4) did not inhibit spontaneous, chlorambucil-, fludarabine-, or radiation-induced apoptosis. However, procaspase 8 processing was induced by all cytotoxic stimuli. These data suggest that the Fas/Fas-L signaling system does not play a major role in the induction of apoptosis in B-CLL cells treated with cytotoxic drugs or radiation. However, Fas-independent activation of caspase 8 may play a crucial role in the regulation of apoptosis in these cells
Obituary announcement about author and labor activist Sh. Mendelson
No full textBrown paper; handpainted. Digitized posters are related to the activities of Jewish displaced persons drawn from the Records of Displaced Persons Camps and Centers in Germany (RG 294.2) Italy (RG 294.3) and Austria (RG 294.4) held by YIVO Archives. Please consult the historical note for those record groups for further information.Digital ImageDigital finding aid available
Sweeping has no effect on renormalized turbulent viscosity
No full textWe perform renormalization group analysis (RG) of the Navier-Stokes equation in the presence of constant mean velocity field , and show that the renormalized viscosity is unaffected by , thus negating the ``sweeping effect", proposed by Kraichnan [Phys. Fluids {\bf 7}, 1723 (1964)] using random Galilean invariance. Using direct numerical simulation, we show that the correlation functions for and differ from each other, but the renormalized viscosity for the two cases are the same. Our numerical results are consistent with the RG calculations
Albumin activates the AKT signalling pathway and protects B-chronics lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis
No full textBONDING AND DYNAMICS OF CNRg AND CRg COMPLEXES
No full textAuthor Institution: Department of Chemistry, Emory University, Atlanta, GA 30322The van der Waals complexes of CN and C with rare gas atoms (Rg) are of interest from the perspectives of their bonding characteristics and predissociation dynamics. Matrix isolation data indicate that that the bonding ranges from a weak van der Waals interaction for the Ne complexes to incipient chemical bonding for Xe. The low-lying vibronic states of CN and C are interleaved, which facilitates electronic energy transfer. Consequently, electronic predissociation of CNRg and CRg complexes provides a useful means to examine the detailed dynamics of electronic energy transfer. Predissociation processes for CNRg complexes have been characterized using double resonance techniques. The final state distributions exhibit symmetry preferences that yield insights concerning the topologies of the relevant potential energy surfaces. In addition, bond energies can be deduced from the predissociation dynamics. Data for the binary complexes CNRg (Rg=Ne, Ar, Kr, and Xe) and CRg will be presented, along with theoretical analyses based on potential energy surfaces
René Géronimo Favaloro : pioneer of Cardiac Surgery
No full textDr. René G. Favaloro moved to the Cleveland Clinic in 1962 and proceeded to reshape the face of cardiac surgery as we knew it. Together with his colleagues at the Cleveland Clinic, Drs. Effler, Sones, Proudfit, Groves, Sheldon and countless others, he contributed to the double internal mammary arterymyocardial implantation by the Vineberg method, and by May 1967, he reconstructed the right coronary artery by the saphenous vein graft interposition. These landmark procedures paved the way for the aorto-coronary saphenous vein bypass graft in October 1967. Many similar breakthroughs ensued, with the application of the bypass technique to the left coronary artery, the combination of coronary artery bypass graft with left ventricular reconstruction and valve repair/replacement and finally, by December, a double bypass to the right coronary artery and anterior descending branch of the left coronary artery. In June, 1971, Dr. Favaloro decided to leave the Cleveland Clinic and return to Argentina where he created a medical centre, a teaching unit, a research department and finally an Institute of Cardiology and Cardiovascular Surgery. This was his greatest personal ambition. Over and above his brilliant mind and craft, Dr. Favaloro was a man of integrity, courage, honesty and humility, whose name will never cease to reverberate throughout the history of medicine.peer-reviewe
A non-classical synthetic strategy for organic mesocrystals
No full textMesocrystals are ordered nanoparticle superstructures, often with internal porosity, which receive much recent research interest in catalysis, energy storage, sensors, and biomedicine area. Understanding the mechanism of synthetic routes is essential for precise control of size and structure that affect the function of mesocrystals. The classical synthetic strategy of mesocrystal was formed via self-assembly of nanoparticles with a faceted inorganic core but a denser (or thicker) shell of organic molecules. However, the potential materials and synthetic handles still need to be explored to meet new applications. In this work, we develop a non-classical synthetic strategy for organic molecules, such as tetrakis (4-hydroxyphenyl) ethylene (TPE-4OH), tetrakis (4-bromophenyl) ethylene (TPE-4Br), and benzopinacole, to produce mesocrystals with composed of microrod arrays via co-solvent-induced crystal transformation. The aligned nanorods are grown epitaxially onto organic microplates, directed by small lattice mismatch between plates and rods. Thus, the present work offers general synthetic handle for establishing well-organized organic mesocrystals.Ministry of Education (MOE)Published versionThe author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the MOE of Singapore (RG 14/13 and RG 5/16), the National Natural Science Foundation of China (No. 21673117), recruitment Program of Global Experts, Jiangsu Provincial Foundation for Specially-Appointed Professor, start-up fund at Nanjing Tech University (39837102), SICAM Fellowship from Jiangsu National Synergetic Innovation Center for Advanced Materials, and Jiangsu Science and Technology Plan (Project No. BK20211258)
Modeling P-Rg conversions from isolated topographic features near the NORESS array
No full textUsing the T-matrix, or extended boundary condition, method, seismic-wave scattering is modelled from earth models with one-dimensional (1D) isolated topographic features. This study is motivated by observations suggesting that surface topography generates coda waves, which are relatively large-amplitude arrivals following major seismic phases. For sinusoidal periodic surfaces, large-amplitude anomalies in the surface displacement spectrum correspond to P-to-Rayleigh (P-Rg), S-to-Rayleigh (S-Rg), and other mode conversions. For isolated topographic features, these conversions still exist. Teleseismic P-Rg conversions from isolated hills were modelled in order to understand and confirm the origin of observed conversions near the NORESS array. -from Author
THEORETICAL INVESTIGATION OF THE M-RG (M = ALKALINE EARTH METAL; RG = RARE GAS) COMPLEXES
No full textAuthor Institution: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK; Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USAMetal cation rare gas complexes provide an expectedly simple system with which to investigate intermolecular interactions. Despite this, we have previously found the M-RG (M = alkaline earth metal) complexes to very complicated systems, with the complexes of the heavier rare gases displaying surprisingly large degrees of chemical character., \textbf{2000}, \textit{114}, 7631.}, \textbf{2010}, \textit{132}, 054302.}, \textbf{2009}, \textit{130}, 194305.} Here we extend these studies by examining the nature of these interactions with increasing degrees of solvation through investigating the M-RG complexes using high level \textit{ab initio} techniques. Intriguing trends in the geometries and dissociation energies of these complexes have been observed and are rationalized
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