1,449 research outputs found
p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies
No full textThe p53 tumor suppressor protein has a key role in the induction of apoptosis of chronic lymphocytic leukemia (CLL) cells. Abnormalities within the p53 pathway identify a subset of patients with a poor prognosis. This review describes recent advances in understanding the mechanisms that regulate p53 levels and the role of p53 in the control of the cell cycle and of apoptosis. The classical model of p53-mediated apoptosis emphasizes the transcriptional activation of proapoptotic genes. In contrast, a novel model emphasizes p53's non-transcriptional actions as the major route of apoptosis induction, whereas its transcriptional arm predominantly upregulates antiapoptotic genes, thus providing a negative feedback mechanism that limits apoptosis. Further studies have identified the Notch pathway as a candidate p53-induced antiapoptotic mechanism. In contrast to the classical model, the novel model predicts that pharmacological inhibition of p53's transcriptional function or of the Notch signaling pathway will augment apoptosis induction by cytotoxic agents. Therapeutic strategies based on the novel model, which we review here for the first time, may significantly augment the antitumor actions of cytotoxic agents in CLL and in other malignancie
LeTourneau modified tank-tree crusher with R.G. LeTourneau and unidentified man.
No full textPhotograph of a Tree Crusher Tender built in Vicksburg, Mississippi and intended for use at the Tournata complex in Liberia, according to author Eric Orlemann. Shown with the tank are R.G. LeTourneau, left, and an unidentified man. The tank was never actually shipped to Tournata
Longview manufacturing plant under construction, LT21 Misc Photos Archive 062.
No full textPhotograph of the Longview manufacturing plant of R.G. LeTourneau, Inc. The plant's construction began in 1945 and completed in 1946. At the time, according to Otis Hays, author of R.G. LeTourneau: Move of Men and Mountains, at the time it was the world's largest welding and manufacturing plant under one roof, covering more than 100 acres
The Big Plow with 6-Foot Disc, J5G, Photo 35, L-8312
No full textPhotograph of R.G. LeTourneau's Series H (Model 6-16) Disc Plow, designed for land-clearing operations. It was powered by a front longitudinally mounted diesel, according to author Eric Orlemann
Large LeTourneau tree crusher, LT20
No full textPhotograph of aLeTourneau tree crusher with three unidentified men. This is likely the Series G-50 Tree Crusher, judging from a similar photo in author Eric Orlemann's book on R.G. LeTourneau's earthmoving equipment
The Added Value of Enterprise Architecture
No full textApplying architecture implies that it provides added value across an enterprise. Although widely adopted, this claim has only been scarcely investigated, not to mention quantified. This document describes the results of a case study to quantify the effects of applying Enterprise Architecture within a financial institution called FinCom. For confidential information reasons, the name of this company is fictive. The thesis attempts to capture several factors at project level with respect to the application of Enterprise Architecture and its subsequent financial benefits. The study analyzed 40 projects, with regard to time and budget overrun. In order to collect these data, a total of 35 business, enterprise and domain architects were interviewed on their experience with these projects. Among factors taken into account were architecture type, project compliance to architecture and experience of the architect. Consequently, these factors are recorded in hypotheses that relate to the budget and time figures of the project. These hypotheses are incorporated in the 'Architecture Effectiveness Model' and statistically tested with the acquired data. This led to more than 12.000 calculations to show the subsequent benefits of Enterprise Architecture.Information ArchitectureComputer ScienceElectrical Engineering, Mathematics and Computer Scienc
Side-Dump Train, built by R.G. LeTourneau, Inc.
No full textPhotograph of the LeTourneau Side-Dump Train designed as a bulk-material hauler. According to author Eric Orlemann, this model consisted of a 6-wheel tractor and two 6-wheel trailers. Only one example was ever built
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro.
No full textWe have studied the in vitro actions of the sesquiterpene lactone parthenolide (PTL) on cells isolated from patients with chronic lymphocytic leukemia (CLL). Dye reduction viability assays showed that the median LD(50) for PTL was 6.2 muM (n=78). Fifteen of these isolates were relatively resistant to the conventional agent chlorambucil but retained sensitivity to PTL. Brief exposures to PTL (1-3 h) were sufficient to induce caspase activation and commitment to cell death. Chronic lymphocytic leukemia cells were more sensitive towards PTL than were normal T lymphocytes or CD34(+) haematopoietic progenitor cells. The mechanism of cell killing was via PTL-induced generation of reactive oxygen species, resulting in turn in a proapoptotic Bax conformational change, release of mitochondrial cytochrome c and caspase activation. Parthenolide also decreased nuclear levels of the antiapoptotic transcription factor nuclear factor-kappa B and diminished phosphorylation of its negative regulator IkappaB. Killing of CLL cells by PTL was apparently independent of p53 induction. This is the first report showing the relative selectivity of PTL towards CLL cells. The data here warrant further investigation of this class of natural product as potential therapeutic agents for CLL
Dataset in support of Guenther, R.G. et al., 2022. "Effects of temperature and pH on the growth, calcification, and biomechanics of two species of articulated coralline algae"
No full textThis dataset supports the manuscript: Guenther, R.G. et al., 2022. "Effects of temperature and pH on the growth, calcification, and biomechanics of two species of articulated coralline algae" in Marine Ecology Progress Series.
DOI: https://doi.org/10.3354/meps14166.
Full author listing is Rebecca Guenther, Elliot M. A. Porcher, Emily Carrington, Patrick T. Martone
Early Carolingian: Italy
No full textThis chapter surveys the use of Early Carolingian minuscule script in Italy. It discusses the transition from various Pre-Caroline cursive bookscripts to a distinctive Italian variant of the Carolingian hand, which occurred gradually after Charlemagne’s conquest of Italy in 774. The author also evaluates the spread of the script through Northern and Central Italy during the ninth and into the tenth century
- …
