1,720,973 research outputs found
Mesenchymal stem cells: Basics and clinical application I
No full textMesenchymal stem cells (MSC) represent one of the most interesting progenitors to date, due to their biodiverse functionalities. Among the fascinating multiple properties of MSC are their supportive roles in wound healing and in the regeneration of damaged tissues and organs. This implies the capacity of MSC to migrate towards injured tissue, to undergo differentiation, to modulate the activation of immune cells and to activate endothelial cells contributing to both angiogenesis and neo-vascularisation. Together with their self-renewal capability, the maintenance of stem cell homeostasis, the release of several bioactive compounds like chemokines, cytokines, micro RNAs and exosomes, MSC can be certainly considered as cellular all-round supporters. These multi-functional MSC properties are highlighted in the present volume. While some chapters are focused on differentiation capacities of MSC, even beyond the more consolidated mesodermal lineages, others provide novel insights into the stimulatory signals involved in MSC survival and trafficking. Moreover, the MSC role in regulating cancer progression for novel therapeutics is assessed. In-depth molecular analyses of MSC functions are also covered, additionally including initial characterisations of distinct proteomic patterns that are specific for discrete MSC populations. Technical aspects for the isolation and enrichment of selected MSC populations are here additionally addressed in relationship to new cell sources and in the attempt to open new therapeutic platforms for potential clinical applications. Although MSC research is progressively bridging to more consolidated clinical applications, it still represents a dynamically developing field, where a variety of intriguing aspects remain to be addressed. We feel this volume represents a comprehensive summary gathering a panel of up-to-date articles which combine the diverse MSC biological functionalities and their potential in translational cell therapy, as highlighted from different angles with a broad interdisciplinary perspective
Mesenchymal Stem Cells - Basics and Clinical Application II
No full textMesenchymal stem cells (MSC) represent one of the most interesting progenitors to date due to their biodiverse functionalities. Among the fascinating multiple properties of MSC are their supportive roles in wound healing and in the regeneration of damaged tissues and organs. This implies the capacity of MSC to migrate towards injured tissue, to undergo differentiation, to modulate the activation of immune cells and to activate endothelial cells contributing to both angiogenesis and neo-vascularisation. Together with their self-renewal capability, the maintenance of stem cell homeostasis, the release of several bioactive compounds like chemokines, cytokines, micro RNAs and exosomes, MSC can be certainly considered as cellular all-round supporters.
These multi-functional MSC properties are highlighted in the present book. While some chapters are focused on differentiation capacities of MSC, even beyond the more consolidated mesodermal lineages, others provide novel insights on the stimulatory signals involved in MSC survival and trafficking. Moreover, MSC role in regulating cancer progression for novel therapeutics is assessed. In-depth molecular analyses of MSC functions are also covered additionally including initial characterizations of distinct proteomic patterns that are specific for discrete MSC populations. Technical aspects for the isolation and enrichment of selected MSC populations are here additionally addressed in relationship to new cell sources and in the attempt to open new therapeutic platforms for potential clinical applications.
Although MSC research is progressively bridging to more consolidated clinical applications, it still represents a dynamically developing field,where a variety of intriguing aspects remain to be addressed. We feel this present book represents a comprehensive summary gathering a panel of up-to-date articles which combine the diverse MSC biological functionalities and their potential in translational cell therapy as highlighted from different angles with a wide interdisciplinary view.Mesenchymal stem cells (MSC) represent one of the most interesting progenitors to date, due to their biodiverse functionalities. Among the fascinating multiple properties of MSC are their supportive roles in wound healing and in the regen- eration of damaged tissues and organs. This implies the capacity of MSC to migrate towards injured tissue, to undergo differentiation, to modulate the acti- vation of immune cells and to activate endothelial cells contributing to both angiogenesis and neo-vascularisation. Together with their self-renewal capability, the maintenance of stem cell homeostasis, the release of several bioactive com- pounds like chemokines, cytokines, micro RNAs and exosomes, MSC can be certainly considered as cellular all-round supporters.
These multi-functional MSC properties are highlighted in the present volume. While some chapters are focused on differentiation capacities of MSC, even beyond the more consolidated mesodermal lineages, others provide novel insights into the stimulatory signals involved in MSC survival and trafficking. Moreover, the MSC role in regulating cancer progression for novel therapeutics is assessed. In-depth molecular analyses of MSC functions are also covered, additionally including initial characterisations of distinct proteomic patterns that are specific for discrete MSC populations. Technical aspects for the isolation and enrichment of selected MSC populations are here additionally addressed in relationship to new cell sources and in the attempt to open new therapeutic platforms for potential clinical applications.
Although MSC research is progressively bridging to more consolidated clinical applications, it still represents a dynamically developing field, where a variety of intriguing aspects remain to be addressed. We feel this volume represents a comprehensive summary gathering a panel of up-to-date articles which combine the diverse MSC biological functionalities and their potential in translational cell therapy, as highlighted from different angles with a broad interdisciplinary perspectiv
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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