952 research outputs found
Deciphering genetic susceptibility to multiple myeloma
No full textMultiple myeloma (MM) is a malignancy characterised by the clonal expansion of plasma cells primarily from the bone marrow. The two- to four-fold increased risk observed in relatives of MM patients provides support for inherited susceptibility to the disease. Genome-wide association studies (GWAS) have implicated common, low penetrance variants in MM susceptibility, however much of the heritability remains unexplained. To search for novel risk loci, a new GWAS and a meta-analysis with previous GWAS and a replication series, totalling 9,974 MM cases and 247,566 controls of European ancestry was performed. These data provide evidence for six new MM risk loci, bringing the total number to 23. Information from gene expression, regulatory profiling and in situ Hi-C data was integrated for the 23 risk loci. Collectively these data implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation, dysregulation of autophagy/apoptosis and cell cycle signalling as key mechanisms. To identify candidate causal genes at GWAS loci and search for novel risk regions, a multi-tissue transcriptome-wide association study (TWAS) was performed by integrating GWAs data with Genotype-Tissue Expression Project (GTEx) data assayed in 48 tissues. 108 genes at 13 independent regions associated with MM risk were identified, all of which were within 1Mb of known MM GWAS risk variants. Of these, 94 genes, located in eight regions, had not previously been considered as a candidate gene for that locus. Clustering of chronic lymphocytic leukaemia (CLL) and MM is observed in families, suggesting an element of shared inherited susceptibility. To examine this, cross-trait linkage disequilibrium (LD)-score regression of MM and CLL GWAS data sets was performed. A significant genetic correlation between these two B-cell malignancies was shown (Rg=0.4, P=0.0046). Furthermore, nine loci pleiotropic to MM and CLL were identified and integration and expression data demonstrated that these pleiotropic risk loci were enriched for B-cell regulatory elements, and implicated B-cell developmental genes. No lifestyle or environmental exposures have been consistently linked to an increased risk of MM. Summary data from GWAS of multiple phenotypes can be exploited in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. An MR-PheWAS was performed analysing 249 phenotypes, proxied by 10,225 genetic variants, and summary GWAS data. Although no significant associations with MM risk were observed among the 249 phenotypes, 28 phenotypes showed evidence suggestive of association, including increased levels of serum vitamin B6 and blood carnitine (P=1.1x10-3) with greater MM risk, and increased levels of total cholesterol, blood esterified cholesterol and omega-3 fatty acids (P=5.4x10-4) with reduced MM risk. Collectively these findings provide insight into genetic and genomic architecture, as well as the aetiology of MM
Molly Ivins: Insights from Molly
No full textMary Tyler Molly Ivins (August 30, 1944 – January 31, 2007) was an American newspaper columnist, author, political commentator, and humorist. Born in California and raised in Texas, Ivins attended Smith College and the Columbia University Graduate School of Journalism. She began her journalism career at the Minneapolis Tribune where she became the first female police reporter at the paper. Ivins joined The Texas Observer in the early 1970s and later moved to The New York Times. She became a columnist for the Dallas Times Herald in the 1980s, and then the Fort Worth Star-Telegram after the Times Herald was sold and shuttered. The column was subsequently syndicated by Creators Syndicate and carried by hundreds of newspapers
Molly Haskell: 03-10-1977
No full textMolly Haskell, film critic for the Village Voice and author of From Reverence to Rape discusses the ways women are portrayed in both film and television. Haskell describes how culture and male influence shape that portrayal and her hopes for the future of women on screen.https://digitalcommons.brockport.edu/writers_videos/1057/thumbnail.jp
Oh, Molly, oh, Molly, Oh, Molly, said he,
No full textvoiceCollected by Max Hunter (H-6 )
For Mary C. Parler
Transcribed by Frances Majors
Sung by Mrs. Ed Newton
Gainesville, Missouri
June 10, 1958
Reel 250, Item 1
Molly Girl
Oh, Molly, oh, Molly,
Oh, Molly, said he,
Go fix up your mind
And be married to thee.
Oh, Willie, oh, Willie,
Oh, Willie, said she,
I am now too young
To be married to thee.
She went to his window
The dawn of the day:
I've now got consent
To be married to thee.
He took her by the hand
And led her o'er the valley so deep,
He led this fair damsel
Till she began to weep.
Oh, Willie, oh, Willie,
Oh, Willie, said she,
I am now afraid
You are going to lead me astray.
Oh, Molly, oh, Molly,
Oh, Molly, said he,
You are guessing just right,
For I was digging of your grave
The biggest part of last night.
He took her by the hand
And led her o'er the valley so deep.
He led this fair damsel
Till she began to weep.
He led her little further
Before she did spy,
Her grave it was dug
And the spade standing by.
She threw her arms around him
And spoke with a fear,
How can you kill a girl
That has loved you so dear.
Molly Girl (Cont'd)
Reel 250, Item 1 (Cont'd)
Oh, Molly, oh, Molly,
Oh, Molly, said he,
I know you're the prettiest girl
That ever was born;
I once enjoyed your beauty,
But now you are gone.
He opened her bosom,
Which is twice as white as snow,
And through her heart he stuck a pen knife,
Which caused much blood to flow.
He laid her in her grave,
And walked off toward home,
Leaving nothing but the small birds
To hear poor Molly's groans.
The ship it was waiting
Along the seaside;
He swore by his Maker
He would sail the other side.
He raised the sail
And away he did fly,
Still thinking of poor Holly
How hard she did die.
The sea it did roar
And the ship it did whirl,
He still a-thinking how hard
He had murdered the poor Molly girl.
He raised his sail
And away he did fly,
Still thinking of poor Molly
How hard she did die.
He sailed and he sailed
To his own heart's content;
At last there sprung a leak in the ship,
To the bottom she went.
Come all you young courters,
And take warning by me;
I warn you of young lovers
Who killed the Molly girl.Funding for digitization provided by the Arkansas Humanities Council and the Happy Hollow Foundation
Oral history interview with Molly Lou Reko
No full textTranscript, 48 pp.Molly Lou Reko grew up in Amarillo, Texas, and graduated from Colorado College in 1958 with a degree in math, then taught mathematics at the Air Force Academy in Colorado Springs. After taking time to raise children, she attended master’s classes at the University of Minnesota (her husband Al Reko then worked for Control Data in Minnesota) in the early 1970s and became connected to the local Minnesota educational computing network TIES, or Total Information for Educational Systems. Her husband encouraged her, with the background in mathematics and teaching, to apply to Control Data. She went to work on the PLATO multi-media computer project. She describes several PLATO programming languages, learning activities or modules, and educational products. She developed PLATO content for the Control Data Institutes, describing William Norris and his deep enthusiasm for PLATO, then managed a group of two dozen PLATO programmers. She also relates her experience with Control Data’s emphasis on corporate social responsibility, including early hiring of women and minorities, as well as work on CDC microcomputers. She completed a master’s degree in computer design and development at University of St. Thomas. In 1989 Control Data’s PLATO division was sold to The Roach Organization (TRO), then in 1991 she went to work for Northwest Airlines initially doing corporate education with microcomputers then working on worldwide installation of computing resources for Northwest’s Airport of Preference system. She offers assessments of Datamation advertisements from the late 1960s.
This material is based on work funded by the Alfred P. Sloan Foundation award B2014-07 “Tripling Women’s Participation in Computing (1965-1985).”Alfred P. Sloan Foundation award B2014-07 “Tripling Women’s Participation in Computing (1965-1985).”Reko, Molly Lou. (2015). Oral history interview with Molly Lou Reko. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/188551
Using Mendelian Randomisation to search for modifiable risk factors influencing the development of clonal haematopoiesis.
No full textMolly visit Timbrook
No full textvoice; pianosCollected by Lana Douthit
For Mary C. Parler
Transcribed by Frances Majors
and played on piano
Sung/by Mrs. Ethyl Cameron
Little Rock, Arkansas
January 2, 1959
Reel 264 , Item 5
Holly and Timbrook
Molly visit Timbrook
To the city of Louisville.
He came from California
To away back in the hills,
Away back in the hills.
Molly said to Timbrook
As I stand here by you,
If I win the money,
I shall wear the blue,
I shall wear the blue.
Timbrook said to Molly,
As we stand here on our feet,
On the Louisville race track,
I never have been beat,
I never have been beat.
The first race that they run
'Twas Molly that led.
The second and third she fell behind,
Timbrook went ahead,
Timbrook went ahead.
Timbrook stands beside
The best upon the land,
While Molly stands beside
A broken-hearted man,
A broken-hearted man.
Car bells began to ringing,
Train began to move.
Timbrook said to Holly,
That takes away my love,
That takes away my love.Funding for digitization provided by the Arkansas Humanities Council and the Happy Hollow Foundation
Good-bye Molly Brown
No full textFirst Line: When I went down to New York townFirst Line of Chorus: What! Ho, Molly, stop yer' bloomin' jollyTitle of Larger Work: Mr. Hamlet of BroadwayKey: D Majo
Molly McCully Brown, 44th Annual ODU Literary Festival
No full textMolly McCully Brown is the author of the essay collection, Places I’ve Taken My Body, which was named one of Kirkus Reviews’ best nonfiction titles of 2020, and the poetry collection, The Virginia State Colony for Epileptics and Feebleminded, which won the 2016 Lexi Rudnitsky First Book Prize. With Susannah Nevision, she wrote the poetry collection In the Field Between Us. The recipient of a United States Artists Fellowship, the Amy Lowell Poetry Traveling Scholarship, and the Civitella Ranieri Foundation and Jeff Baskin Writers fellowships, Brown is an assistant professor of English and creative nonfiction at Old Dominion University
Regions of homozygosity as risk factors for multiple myeloma
No full textGenomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk
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