8,391 research outputs found
Guest Editorial Special Issue on Computational Modeling of Neural and Brain Development
No full textJin Y, Meng Y, Weng J, Kasabov N. Guest Editorial Special Issue on Computational Modeling of Neural and Brain Development. IEEE Transactions on Autonomous Mental Development. 2011;3(4):273-275
Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells
No full textHonokiol, an active compound derived from Magnolia spp. bark, possesses chemopreventive properties in many cancer cell models. However, the chemopreventive mechanism of honokiol in lung cancer cells is still a mystery. We examined histone deacetylase 6 (HDAC6)-mediated epidermal growth factor receptor (EGFR) stability in honokiol-treated lung cancer cells. The results showed that honokiol induced G1 growth arrest was through down-regulation of EGFR expression and thereafter downstream signaling pathways. HDAC6 activity was directly inhibited via honokiol at IC50 about 23.55 +/- 1.18 mu M. Inhibition of HDAC6 activity via honokiol was followed by disrupting HDAC6 and heat shock protein 90 (Hsp90) association and resulting in Hsp90 hyper-acetylation. Meanwhile, hyper-acetylated Hsp90 had been found to disassociate with EGFR and followed by EGFR degradation. Taken together, these results suggested that interruption of EGFR stability by honokiol was through inhibiting HDAC6 activity and consequently suppressing Hsp90 chaperon function in lung cancer cells. (C) 2015 Elsevier Ltd. All rights reserved
ChIA-PET2: A Versatile and Flexible Pipeline for ChIA-PET Data Analysis
No full textChIA-PET2 is a versatile and flexible pipeline for analyzing different types of ChIA-PET data from raw sequencing reads to chromatin loops. ChIA-PET2 integrates all steps required for ChIA-PET data analysis, including linker trimming, read alignment, duplicate removal, peak calling and chromatin loop calling. It supports different kinds of ChIA-PET data generated from different ChIA-PET protocols and also provides quality controls for different steps of ChIA-PET analysis. In addition, ChIA-PET2 can use phased genotype data to call allele-specific chromatin interactions. We applied ChIA-PET2 to different ChIA-PET datasets, demonstrating its significantly improved performance as well as its ability to easily process ChIA-PET raw data. ChIA-PET2 is available at https://github.com/GuipengLi/ChIA-PET2. © The Author(s) 2016.National Basic Research Program of China [2012CB316503]; National High Technology Research and Development Program of China [2012AA020401]; National Natural Science Foundation of China [91519326, 31361163004 and 31301044]; National Institutes of Health grants [HG001696, 5U01HG007919-02, 5U54HG00699604 and 5P50HG00773502]. National Basic Research Program of China [2012CB316503].School of Natural Sciences and Mathematic
sj-pdf-1-pev-10.1177_22840265221093262 – Supplemental material for Gastrointestinal symptoms as a predictor of deep endometriosis of the pelvic posterior compartment on magnetic resonance imaging
No full textSupplemental material, sj-pdf-1-pev-10.1177_22840265221093262 for Gastrointestinal symptoms as a predictor of deep endometriosis of the pelvic posterior compartment on magnetic resonance imaging by Priyal Praful Fadadu, Adela Cope, Chia-Sui Weng, Kristin Mara, Zaraq Khan, Wendaline VanBuren and Tatnai Burnett in Journal of Endometriosis and Pelvic Pain Disorders</p
Brahms Female Choral Works Op.17
No full textBrahms is an important German romantic composer.In additional to his outstanding output in orchestral composition, he also finished thirty-four female choral pieces. Most of them were written during 1857-62, when he was still in Hamburg and dirdcting the Hamburg Women's Chorus. Opus17 belongs to this category. It is for three-part female choir, with harp and horns as the accompaniment. It includes four short pieces, text in German, with the feeling of lament. The form is simple and clear. The texture is mostly choral. The melodies in each vocal part are not difficult; however, it is the harmonic color that gives this work its special taste.
This thesis consists of five chapters. The first chapter is the introduction. The second chapter inclides three parts. Part one introduces the life of Brahms. Part two is the chronological discussion of Brahms choral composing. Part three focuses on the female choral works. The third chapter analyzes the four pieces of Brahms Opus 17. The fourth chapter presents suggestions for teaching Opus 17, including vocalization, interpretation, diction, and conducting technique. The fifth chapter draws conclusion from the study
Migrant workers, collaborative research and spatial pressures : an interview with Meng Yue
No full textIn July last year I had the opportunity to interview Meng Yue, literary scholar and author of Shanghai and the Edges of Empire (2006). Meng Yue has been collaborating with Toronto-based architect and artist Adrian Blackwell for a number of years, with their students from literature and architecture undertaking highly interesting research on the peripheral zones of Beijing. Questions of peri-urban food production, land use, resource distribution and the multiplication of labour skills have framed these investigations. The interview below is extracted from a considerably longer discussion we had in Beijing during the late summer of 2007, half of which was lost to the faulty battery of an ipod (the rest remains to be transcribed from video…)
The Construction of the Hung-lou-meng 紅樓夢
No full textThe Hung-lou-meng of Ts'ao Chan 曹霑 seems to be divided into two parts; the chapters from the beginning to the fifty-fourth depict the glorious days of the Chia 賈 family, whereas the chapters 54 to 80, where Ts'ao terminated his writing chores, depict the decline of the family. The eventual decline is cleverly suggested in various parts of the first section, and is realized in the second section. Examining closer the first section, the author finds that it again is divided into three parts, each part comprising eighteen chapters. There are further indications that such was also the plan of Ts'ao Chan for the second section, again three parts, each of which were to comprise approximately eighteen chapters
sj-docx-2-tct-10.1177_15330338221106855 - Supplemental material for TJP1, a Membrane-Expressed Protein, is a Potential Therapeutic and Prognostic Target for Lung Cancer
No full textSupplemental material, sj-docx-2-tct-10.1177_15330338221106855 for TJP1, a Membrane-Expressed Protein, is a Potential Therapeutic and Prognostic Target for Lung Cancer by Junyi Pu, Tao Ai, Weining Weng, Lijun Wang, Yuan Yang, Linjie Ma, Zhiping Hu, and Xun Meng in Technology in Cancer Research & Treatment</p
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