1,721,394 research outputs found
sj-docx-1-mpp-10.1177_23814683231187566 – Supplemental material for Expected Health Benefits of SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Older Adults
No full textSupplemental material, sj-docx-1-mpp-10.1177_23814683231187566 for Expected Health Benefits of SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Older Adults by Rahul S. Dadwani, Wen Wan, M. Reza Skandari and Elbert S. Huang in MDM Policy & Practice</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-kappa B Transactivation Inhibition
No full textVariations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
DS_10.117_0272989X18803109 – Supplemental material for Cost-effectiveness of Initiating an Insulin Pump in T1D Adults Using Continuous Glucose Monitoring Compared with Multiple Daily Insulin Injections: The DIAMOND Randomized Trial
No full textSupplemental material, DS_10.117_0272989X18803109 for Cost-effectiveness of Initiating an Insulin Pump in T1D Adults Using Continuous Glucose Monitoring Compared with Multiple Daily Insulin Injections: The DIAMOND Randomized Trial by Wen Wan, M. Reza Skandari, Alexa Minc, Aviva G. Nathan, Parmida Zarei, Aaron N. Winn, Michael O’Grady and Elbert S. Huang in Medical Decision Making</p
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Study of the characteristic among three different pathways for telomere maintenance in Saccharomyces cerevisiae
No full text端粒維持對於染色體的穩定，細胞生長分裂都有很重要的地位，在一般的細胞當中利用端粒酵素來維持端粒，而細胞缺乏端粒酵素時，會利用二種不同的重組方式來維持端粒，這樣的維持有助於癌症細胞的增生。在本研究中，我們於雙套染色體上提供兩種不同的端粒模式，再追蹤其端粒延長之形式。發現當有端粒酵素存在時，大部分細胞還是會以端粒酵素來維持其端粒，不過少數也會以Type II的重組方式延長端粒，可見單套正常的RNA模板並不足以維持所有的端粒延長。在雙套酵母菌中發現，在端粒酵素缺乏時，細胞如果先有一種端粒延長方式，細胞會延用這樣的機制去延長端粒，如果沒有任何預先給的延長方式，細胞在液態培養基中還是會以Type II方式延長端粒，而在固態培養基中，Type I發生頻率較高。
利用此菌株，觀察其他端粒特性，發現Type I端粒幾乎沒有端粒位置效應，不過端粒丟失情形則沒有太大差異。此外，藉著觀察單一染色體末端，我們發現細胞內可以同時存在不同的端粒-端粒重組形式，而且已經利用端粒-端粒重組方式的端粒也是會被端粒酵素作用。而不同的化學物質可以對於不同存活者有不同的影響，顯示細胞壓力的確也會對於端粒重組造成影響。Telomere maintenance is required for chromosome stability and cell proliferation. Telomeres are replicated by the action of the reverse transcriptase, telomerase. In budding yeasts that lack telomerase, telomeres are maintained by two different pathways of telomere-telomere recombination. In this study, we created two different telomeric patterns in each diploid cell and followed their telomere pattern. We found that cells prefer to maintain their telomere by telomerase when telomerase activity is present. But in these strains, type II pattern of telomere-telomere recombination sometimes appears and quickly disappeared. One allele of wild type Tlc1 is not sufficient for maintaining all telomeres well. When one mechanism is predeposited in diploid strains, cell would use this mechanism to elongate their telomeres. In diploid strains, type II survivors appear in liquid culture when there is no predeposited telomere-telomere recombination pathway. By contrast, most survivors on solid plate are type I.
Using these strains, study other telomere characteristics. We found that telomere position effect is decreased sharply in type I telomere, and telomere loss was not different. Using an assay to trace a single chromosome end, we show here that different telomere-telomere recombination mechanism can coexist in the same cell. And, some genomic toxic agents inhibit survivors’ growth differently. Moreover, suffering environmental pressure influence the preference of telomere recombination.目錄•••••••••••••••••••••••••••••••••••••••••••••••••••1
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