1,725,143 research outputs found

    Session #4: Round Table - Meryl Weinreb, Moderator

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    Meryl Weinreb is a retired pharmaceutical marketing executive with extensive experience in oncology – both from an industry and personal perspective. As a 3-time breast cancer survivor, she was uniquely equipped to successfully lead consumer marketing strategy and execution for AstraZeneca’s US oncology portfolio. She was responsible for a number of awarding-winning patient education and support programs for breast, prostate, and lung cancer therapies. Ms. Weinreb served for 7 years on the executive board of the Philadelphia affiliate of the Susan G. Komen Foundation, a nonprofit organization that educates the community about breast cancer and funds research, screening, and support programs. She currently is the affiliate’s Education and Public Policy Chair. In 2013, she was invited to join Komen’s Advocates in Science Program and recently became a member of the group’s national steering committee. As a Komen Scholar, she chairs the Advocate in Science Committee on Peer Review and is Vice Chair of the group’s Education and Training subcommittee. She has extensive experience as a patient advocate reviewer for the Department of Defense’s Breast Cancer Research Program and the Cancer Prevention Research Institute of Texas, as well as for Komen award programs. She assists researchers - locally, across the country and sometimes abroad - with their grant applications, and currently is collaborating as a patient advocate on several breast cancer research projects where she helps to assure a patient focus in their scientific work

    Session #1: Round Table - Meryl Weinreb, Moderator

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    Meryl Weinreb is a retired pharmaceutical marketing executive with extensive experience in oncology – both from an industry and personal perspective. As a 3-time breast cancer survivor, she was uniquely equipped to successfully lead consumer marketing strategy and execution for AstraZeneca’s US oncology portfolio. She was responsible for a number of awarding-winning patient education and support programs for breast, prostate, and lung cancer therapies. Ms. Weinreb served for 7 years on the executive board of the Philadelphia affiliate of the Susan G. Komen Foundation, a nonprofit organization that educates the community about breast cancer and funds research, screening, and support programs. She currently is the affiliate’s Education and Public Policy Chair. In 2013, she was invited to join Komen’s Advocates in Science Program and recently became a member of the group’s national steering committee. As a Komen Scholar, she chairs the Advocate in Science Committee on Peer Review and is Vice Chair of the group’s Education and Training subcommittee. She has extensive experience as a patient advocate reviewer for the Department of Defense’s Breast Cancer Research Program and the Cancer Prevention Research Institute of Texas, as well as for Komen award programs. She assists researchers - locally, across the country and sometimes abroad - with their grant applications, and currently is collaborating as a patient advocate on several breast cancer research projects where she helps to assure a patient focus in their scientific work

    Secure linear algebra using linearly recurrent sequences

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    In this work we present secure two-party protocols for various core problems in linear algebra. Our main building block is a protocol to obliviously decide singularity of an encrypted matrix: Bob holds an n × n matrix M, encrypted with Alice’s secret key, and wants to learn whether the matrix is singular or not (and nothing beyond that). We give an interactive protocol between Alice and Bob that solves the above problem with optimal communication complexity while at the same time achieving low round complexity. More precisely, the number of communication rounds in our protocol is polylog(n) and the overall communication is roughly O(n 2) (note that the input size is n 2). At the core of our protocol we exploit some nice mathematical properties of linearly recurrent sequences and their relation to the characteristic polynomial of the matrix M, following [Wiedemann, 1986]. With our new techniques we are able to improve the round complexity of the communication efficient solution of [Nissim and Weinreb, 2006] from n 0.275 to polylog(n). Based on our singularity protocol we further extend our result to the problems of securely computing the rank of an encrypted matrix and solving systems of linear equations. Key words. Secure Linear Algebra, Linearly Recurrent Sequences, Wiedemann’s Algorithm.

    Ligand-Enabled, Palladium-Catalyzed Beta-C (sp3)–H Arylation of Weinreb Amides

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    We report the development of Pd(II)-catalyzed C(sp3)–H arylation of Weinreb amides. A pyridinesulfonic acid ligand is designed to accommodate the weak, neutral coordinating property of Weinreb amides via preserving the cationic character of Pd center through zwitterionic assembly of Pd/ligand complexes. DFT studies of the C–H cleavage step indicate that the superior reactivity of 3-pyridinesulfonic acid ligand compared to pyridine, Ac-Gly-OH, and ligandless conditions originates from the stabilization of overall substrate-bound Pd species. </em

    Social inequality and HIV-testing

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    The plan to increase HIV testing is a cornerstone of the international health strategy against the HIV/AIDS epidemic, particularly in sub-Saharan Africa. This paper highlights a problematic aspect of that plan: the reliance on clinic- rather than home-based testing. First, drawing on DHS data from across Africa, we demonstrate the substantial differences in socio-demographic and economic profiles between those who report having ever had an HIV test, and those who report never having had one. Then, using data from a random household survey in rural Malawi, we show that substituting home-based for clinic-based testing may eliminate this source of inequality between those tested and those not tested. This result, which is stable across modeling frameworks, has important implications for accurately and equitably addressing the counseling and treatment programs that comprise the international health strategy against AIDS, and that promise to shape the future trajectory of the epidemic in Africa and beyond.AIDS/HIV, home-based testing, inequality, Malawi

    Efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides through a simple work-up procedure

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    An efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides is described. Quenching with nonaqueous HCl avoided side reactions associated with typical work-up procedures. The amide reacted with various nucleophiles to give the corresponding ketones in high yields. A novel reactivity of the Weinreb amide is also discussed

    Weinreb

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    Weinreb amides : novel titanium enolate reagents

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    The amides of N-methoxy-N-methylamine or Weinreb amide have earned an important role in synthetic chemistry as both a protective group and as synthetic intermediates. We have discovered that the Weinreb amide of acetic acid, N-methoxy-N-methylacetamide adds to aldehydes to afford classic aldol products in good to excellent yields. The scope of this novel aldol reaction will be discussed

    Palladium-catalyzed arylation of alpha,beta-unsaturated Weinreb amides

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    Palladium-catalyzed arylation of α,β-unsaturated Weinreb amides has been examined to obtain β-aryl-α,β-unsaturated Weinreb amides. The chelation between the palladium center of an alkylpalladium intermediate and Weinreb amide moiety facilitated both coordination and insertion steps.open
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