1,135 research outputs found
FIGURE 1 in A new species of the genus Coraebus from China (Coleoptera: Buprestidae: Agrilinae)
No full textFIGURE 1. Coraebus bimaculatus sp. nov. A–B. habitus ♂, holotype, in dorsal and ventral views; C–D. habitus ♀, paratype, in dorsal and ventral views; E. mesotibia ♂, holotype; F. metatibia ♂, holotype, G–H. aedeagus, holotype, in dorsal and ventral views.Published as part of Wei, Zhonghua, Xu, Hongxia & Shi, Aimin, 2022, A new species of the genus Coraebus from China (Coleoptera: Buprestidae: Agrilinae), pp. 146-150 in Zootaxa 5099 (1) on page 148, DOI: 10.11646/zootaxa.5099.1.8, http://zenodo.org/record/603704
Coraebus bimaculatus Wei & Xu & Shi 2022, sp. nov.
No full textCoraebus bimaculatus sp. nov. (Figs. 1A–H) Type material. Holotype: ♂, China, Guangxi, Jinxiu, Dayaoshan Mts., 600–700 m, 18.IV.2021, Chunfu Feng leg., CWNU. Paratypes: 2♂ 2♀, same data as holotype, CWNU; 4♂ 4♀, S. China, N. Guangdong, Nanling, 600–1400 m, 1–6. VI.2006, M. Takakuwa leg., COTJ, VKCB; 1♀, China, Hunan, Yizhang, Mangshan Mts., Jiangjunzhai, 700 m, 31. V.2021, Zhonghua Wei leg., CWNU (in in 95% ethanol). Other examined material. 1♀, Guangdong, Shaoguan, Nanling, Yuehuang Ecological Garden, 22.V. 2021, 566 m, Zhonghua Wei leg., CWNU (in 95% ethanol); 1♀, Guangxi, Jinxiu, Dayaoshan Mts., 600–700 m, 18.IV.2021, Chunfu Feng leg., CWNU (in 95% ethanol). Male (Figs. A–B). Body length 11.0– 12.5 mm. Body elongate, cylindrical. Head, pronotum and scutellum golden with reddish tinge, elytra blue, ventral surface golden. Elytral surface with dense red-brown pubescence and two transverse spots, ventral surface with long yellow pubescence. Labrum densely covered with long and yellow pubescence. Frontoclypeal keel distinct, straight, at the center of antennal grooves. Impression above frontoclypeal keel connected to supra-antennal grooves. Frons with deep longitudinal median impression. Supra-antennal grooves wide, open at outer side, carina above supra-antennal grooves connected in the middle, sinuate. Vertex with distinct longitudinal median line. Antennal grooves large with inner margin elevated and forming keel, outer margin open obliquely downwards. Sculpture of head formed by punctation and furrows, punctures well-separated. Antennae serrate from antennomere IV, antennomeres I–III subconical, antennomere I thickest, antennomere III–XI subequal in length and much shorter than antennomere II. Pronotum widest just behind middle (at posterior 1/3, moderately tapering forwards, weakly backwards), approximately 1.6 times as wide as long; anterior margin slightly and arcuately produced in middle, posterior margin lobe-like produced towards scutellum and sinuate sidewards. Surface of prosternum and prosternal process (Fig. 2A) slightly impressed. Scutellum strongly transverse, subcordate, 3.0 times as wide as long, surface smooth, with small punctures, impressed at middle. Elytra approximately 2.5 times as long as wide, lateral margins in anterior 1/3 subparallel, gradually slightly arcuate widening to middle, then gradually narrowing to apex. Apex emarginate, lateroposterior margin with small serrations. Each elytron with one transverse spot composed of yellow pubescence. Legs slender. Apical inner margin of mesotibia serrate behind middle (Fig. 1E). Apical inner margin of metatibia serrate, concaved before apex, and apex with a big flat spine (Fig. 1F). Ventrites (Fig. 2B) with dense and long pubescence. Ventrite I with longitudinal impression at middle; ventrites I–IV with transverse impressions at lateral portion; posterior margin of ventrite V (Fig. 2C) concave, middle of impression with a distinctly produced spine. Lateral sides of tegmen weakly concave before parameral membrane. Parameral membrane of tegmen well developed, with very short setae, parameres narrower than pallobase. Apex of phallus narrow and rounded. Female (Figs. 1C–D). Body length 12.0– 13.5 mm. Elytral surface with four spots at posterior portion (Fig. 1C). Mesotibia and metatibia without serrations at apical inner margin. Inner apex of metatibia also without spines. Diagnosis. This new species resembles Coraebus violaceipennis Saunders, 1866 (widely distributed in China, India, Kampuchea, Laos, Nepal, Thailand and Vietnam) by color pattern and body shape, however, can be easily distinguished from the latter by the elytral surface with two spots composed of yellow pubescence at apical portion in male (elytral surface with four spots in female), apex of metatibia with a big flat spine in male, ventrite V with distinctly concave posterior margin in male and female, and parameral membrane of tegmen with very short setae (that of C. violaceipennis with long setae, Fig. 2J). Etymology. The specific epithet refers to the male elytral surface with two pubescence spots. Distribution. China: Guangxi, Guangdong, Hunan.Published as part of Wei, Zhonghua, Xu, Hongxia & Shi, Aimin, 2022, A new species of the genus Coraebus from China (Coleoptera: Buprestidae: Agrilinae), pp. 146-150 in Zootaxa 5099 (1) on page 147, DOI: 10.11646/zootaxa.5099.1.8, http://zenodo.org/record/603704
sj-docx-1-taj-10.1177_20406223231223285 – Supplemental material for Effect of short-term cardiac function changes after cardiac resynchronization therapy on long-term prognosis in heart failure patients with and without diabetes
No full textSupplemental material, sj-docx-1-taj-10.1177_20406223231223285 for Effect of short-term cardiac function changes after cardiac resynchronization therapy on long-term prognosis in heart failure patients with and without diabetes by Yu Yu, Ligang Ding, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu and Wei Hua in Therapeutic Advances in Chronic Disease</p
Coraebus violaceipennis Saunders 1866
No full textCoraebus violaceipennis Saunders, 1866 (Figs. 2D–J) Coraebus violaceipennis Saunders, 1866: 313. Coraebus quadraticollis Fairmaire, 1895: 174. Type material examined: Holotype, ♀, Laos [without exact data], Mouhot / H. T. Type [round label with red margin] / Type / Saunder 74.18. / Coraebus violaceipennis Type Saunders, BMNH. Other examined material: 1 sex unknow, Laos, Louang Nantha pt, Namtha to Muang Sing, 21°09′N, 101°19′E, 5–31. V.1997, 900– 1200 m, Vít. Kubáň leg / Coraebus violaceipennis Saunders, 1866, Vít. Kubáň det, 1997, VKCB; 1♀, China, Gansu, Wenxian, Bikou, 22.VII. 2001, 870 m, Hongjian Wang leg., BNRG; 1♀, China, Zhejiang, Tianmushan Mts., 2.IX.1941, collector unknown, IZAS; 1♀, China, 20. V. 1981, Niancong Chen leg., IZAS; 1♀, China, Hunan, Huaihua, V.2020, Haohan Mao leg., CWNU (in 95% ethanol). Distribution. China: Fujian, Gansu, Guizhou, Hubei, Hunan, Jiangxi, Yunnan, Zhejiang. India; Kampuchea, Laos, Nepal, Thailand, Vietnam (Kubáň, 1996, Kubáň, 2016).Published as part of Wei, Zhonghua, Xu, Hongxia & Shi, Aimin, 2022, A new species of the genus Coraebus from China (Coleoptera: Buprestidae: Agrilinae), pp. 146-150 in Zootaxa 5099 (1) on page 149, DOI: 10.11646/zootaxa.5099.1.8, http://zenodo.org/record/603704
EB1 acts as an oncogene via activating ?-catenin/TCF pathway to promote cellular growth and inhibit apoptosis
No full textPreviously we showed that end-binding protein 1 (EB1) may promote cellular growth by activating ?-catenin/T-cell factor (TCF) pathway. To further investigate the role of EB1 in regulating cellular growth, we established an EB1-inducible expression system in which the protein level of EB1 was significantly upregulated upon doxycycline induction. We found that EB1 promoted cellular growth and resulted in a significant increase in colony formation. In addition, EB1 could induce tumor formation in nude mice, activate ?-catenin-dependent gene expression and upregulate the transcriptional activity of c-myc. We also showed that EB1 in this manner inhibited apoptosis of 293-T-REx cells upon cisplatin and upregulated expression of Bcl-2, whereas ?N TCF4, an inhibitor of ?-catenin/TCF pathway, could completely or partially abolish the effects of EB1 on the promotion of cell growth and the inhibition of apoptosis activity. Moreover, knockdown of c-myc by RNAi could abrogate upregulation of EB1-dependent induction of Bcl-2 expression. Overall, EB1 acts as a potential oncogene via activating ?-catenin/TCF pathway to promote cellular growth and inhibit apoptosis
Krüppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines
No full textAberrant expression of survivin has been shown to be regulated at the transcription level in cancer cells. In this study, we demonstrate that there are six putative binding sites of Krüppel-like factor 4 (KLF4) within the 2000-bp region upstream of the transcription start site of the human survivin gene. Luciferase reporter gene assays revealed that survivin promoter activity is repressed upon overexpression of KLF4 in EC9706 cells. A chromatin immunoprecipitation assay indicated that KLF4 indeed binds the survivin promoter in vivo. It specifically binds the site located at position -40 among the six binding sites as determined by electrophoretic mobility shift assay. Ectopic expression of KLF4 decreases the mRNA and protein levels of survivin. Furthermore, overexpression of survivin partially reverses KLF4-induced cell apoptosis. These results indicate that KLF4 is a transcriptional repressor of the human survivin gene in esophageal squamous cancer cells
?-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
No full textPrecise roles of ?-catenin/TCF pathway involved in esophageal tumorigenesis remain elusive. Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with ?-catenin cytoplasmic/nuclear accumulation. A functional TCF binding element was detected in STAT3 promoter which specifically bound to TCF4. Transfected ?-catenin induced STAT3 transcriptional activity dose-dependently, and also enhanced STAT3 mRNA and protein levels. These inductions were specifically abolished by dominant-negative TCF4. These results suggest that STAT3 is a target of ?-catenin/TCF pathway and might participate in esophageal tumorigenesis
A Multiscale Investigation on the Mechanism of Shape Recovery for IPDI to PPDI Hard Segment Substitution in Polyurethane
No full textShape memory thermoplastic polyurethane (SMTPU) containing isophorone diisocyanate (IPDI) in hard segment has excellent shape recoverability even after large strain deformation. However, the underlying mechanism of shape recovery remains unclear. In this study, 1,4-phenylene diisocyanate (PPDI) in the polyurethane is gradually substituted by IPDI, and multiscale effects are examined by normal and dichroic Fourier transform infrared spectroscopy (FTIR), small angle X-ray scattering (SAXS), single-molecule force spectroscopy (SMFS), and mechanical test. Contradictory to the traditional conclusion, the degree of microphase separation decreases as the content of IPDI increases, while the macroscopic shape recoverability is largely improved. With dichroic FTIR and SAXS, we find that the morphology of hard phases changed from lamellar-like to fibrillar-like, which is more stable under stretching. SMFS experiments discover that IPDI could increase the elasticity of polymer chain and could endow the hard phases with "elastic" under stress. With these two factors, we are able to explain the high recoverability of the SMTPU containing IPDI
FRAT1 overexpression leads to aberrant activation of ?-catenin/TCF pathway in esophageal squamous cell carcinoma
No full textEsophageal squamous cell carcinoma (ESCC) is an aggressive tumor with a poor prognosis. Although aberrant activation of ?-catenin/T-cell factor (TCF) pathway has been observed in ESCC, mechanisms underlying this phenomenon remain unknown. Frequently rearranged in advanced T-cell lymphomas-1 (FRAT1), overexpressed in some ESCC lines, is a positive regulator of ?-catenin/TCF pathway. However, little is known about the molecular relationship between FRAT1 and ?-catenin/TCF in ESCC. In this study, we analyzed freshly resected ESCC specimens and demonstrated that FRAT1 was overexpressed in approximately 74% of tumor samples compared with matched normal tissue. Overexpression of FRAT1 significantly promoted esophageal cancer cells growth, whereas suppression of FRAT1 level by RNAi markedly inhibited their growth. In addition, FRAT1 overexpression induced the nuclear accumulation of ?-catenin and promoted the transcriptional activity of ?-catenin/TCF. These effects were reversed by coexpression of GSK 3? or ?N TCF4. Furthermore, accumulation of ?-catenin was correlated with FRAT1 overexpression in ESCC and the basal layer of normal esophageal epithelium. Finally, continued expression of c-Myc is necessary and sufficient for maintenance of the growth state in cells expressing FRAT1. Taken together, these results support the novel hypothesis that aberrant activation of ?-catenin/TCF pathway in esophageal cancer appears to be due to upstream events such as FRAT1 overexpression, and c-Myc may be an important element in oncogenesis of human ESCC induced by FRAT1
Suppression of Aurora-A oncogenic potential by c-Myc downregulation
No full textThe abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression
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