1,721,124 research outputs found

    Epidemiology and natural history of human papillomavirus around the time of sexual debut

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    Human papillomavirus (HPV) is a sexually transmitted virus associated with cervical cancer. The East African region has one of the highest incidences and mortality rates from cervical cancer but limited studies on HPV are available. Research aims were to describe: HPV genotypes, risk factors and rate of acquisition of prevalent and incident HPV in girls before and after reported first sex; rate and risk factors associated\ud with HPV clearance, and to examine sexual behaviour reporting in face-­‐to-­‐face (FtF) interviews compared to Audio Computer-­‐Assisted Self-­‐Interviews (ACASI). A total of 503 girls aged 15 and 16 years in Mwanza, Tanzania, were enrolled and followed 3-­‐ monthly for 18 months with FtF-­‐interviews and self-­‐administered vaginal swabs. At enrolment, 474 girls reported no previous sex, and HPV was detected in 40/474(8.4%). During follow-­‐up of girls who reported sex, new HPV incidence was 225/100 person-­‐years(pys). Reporting sex in the past 3 months, and knowing the most recent sexual partner for a longer period before sex were associated with HPV acquisition. Median time from reported sexual debut to first HPV infection was 5 months, and median duration of infection 6 months. No factors were associated with HPV clearance. In girls who reported not having sex, HPV incidence was 29.4/100pys. ACASI was compared to FtF-­‐interview in 203 girls at the 12-­‐month visit. Although ACASI was feasible and acceptable, there was no increase in reporting of sex or other sexual behaviours, with the exception of kissing, compared to FtF-­‐interviews. A very high incidence of HPV was seen in girls following sexual debut, and a higher than expected HPV prevalence and incidence were seen in girls who reported no previous sex. This emphasises the importance of HPV vaccination well before sexual debut. ACASI did not lead to increased reporting of vaginal sex and should be evaluated further in different settings

    Implementation of prevention of mother-to-child transmission of HIV and maternal syphilis screening and treatment programmes in Mwanza region, Tanzania : uptake and challenges

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    ABSTRACT Literature and other background information on prevention of mother-to-child transmission of HIV (PMTCT) and maternal syphilis screening programmes in Tanzania reveal that little has been documented on accessibility and utilization of these services. This thesis presents the results from a research conducted in Mwanza city, Tanzania to assess the operational performance of PMTCT and maternal syphilis screening and treatment during pregnancy, at delivery and in the postnatal period. From different sub-studies conducted at the antenatal clinics (ANC) and in the maternity ward for this research, a number of missed implementation opportunities were identified. A review of records found that 24% of pregnant women who delivered in hospital left the maternity ward with unknown HIV status and 50% of HIV-positive women tested at ANC did not receive Antiretroviral therapy (ART) for PMTCT. A cross-sectional study at the maternity ward found that 12% of pregnant women who were not screened for syphilis, 27% of RPR-positive women who were not treated at ANC, and all infants of RPR-positive women did not receive any intervention to prevent congenital syphilis. Forty-one percent of HIV-positive women recruited in the cohort study successfully completed all PMTCT interventions. Only 18% of HIV-positive women identified through PMTCT were successfully referred to, and attended an adult care and treatment clinic (CTC). Of 403 HIV- positive women in the cohort study, 50% did not intend to get pregnant and by four months postpartum, 20% of them reported to have not received any counselling on family planning. HIV-positive women who did not receive counselling on FP use were at a higher risk of not using contraception compared to those who were counselled (adj. OR=6, 95% Cl; 2.8-12.9). About 27% of HIV-positive mothers were not counselled regarding infant feeding and 40.2% of women who were not counselled on infant feeding were undecided on how to feed their infants before they left the hospital compared to only 2.5% of women who were counselled (P<O.OOl) It was found that pregnant women attending ANC for the first time during pregnancy spent between three and 5.5 hours at the clinic, on average, 78% of this time was spent waiting for services. 6 Fewer ANC visits, attending private or rural ANC facilities, failure to attend a CTC prenatally, and lack of knowledge among users and provider of health services were factors found to hamper the performance of the programmes. Integration of these programmes at all levels and training of health workers in basic components of the programmes are fundamental to the successful implementation of the programme

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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