3,343 research outputs found
Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
No full textApo E plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface LDL receptor. In the present study we studied the effects of apo E on the atherogenic process in Watanabe heritable hyperlipidemic rabbits which are deficient in LDL receptor and an animal model for familial hypercholesterolemia. We isolated apo E from plasma of 1% cholesterol-fed rabbits and administered 10 mg of purified apo E intravenously into five Watanabe heritable hyperlipidemic rabbits three times a week from their age of 2.5 months to 11 months for 8.5 months. After sustained administration to apo E we found a significant reduction in the accumulation of cholesterol ester in aortae (1.55 +/- 0.07 mg/g tissue) as compared to control rabbits (4.32 +/- 0.61 mg/g tissue). Supporting this the percentage of the surface area of the aorta with macroscopic plaque was remarkably decreased in apo E-treated animals (18.8 +/- 5.1% vs. 38.8 +/- 8.0% in control). Thus apo E definitely prevented the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.journal articl
sj-docx-2-jet-10.1177_15266028241248311 – Supplemental material for Early Clinical Results From the Japanese Prospective Multicenter Study to Evaluate Zenith Alpha Abdominal Stent Graft for Abdominal Aortic Aneurysm (JUSTICE) Registry Demonstrate Acceptable Limb Patency at 12 Months
No full textSupplemental material, sj-docx-2-jet-10.1177_15266028241248311 for Early Clinical Results From the Japanese Prospective Multicenter Study to Evaluate Zenith Alpha Abdominal Stent Graft for Abdominal Aortic Aneurysm (JUSTICE) Registry Demonstrate Acceptable Limb Patency at 12 Months by Naoki Fujimura, Shigeo Ichihashi, Tsuyoshi Shibata, Hitoshi Matsumura, Michiko Watanabe, Noriyasu Morikage, Yoshihiko Kurimoto, Hiroshi Banno, Hidetoshi Uchiyama and Hideaki Obara in Journal of Endovascular Therapy</p
sj-tiff-3-jet-10.1177_15266028241248311 – Supplemental material for Early Clinical Results From the Japanese Prospective Multicenter Study to Evaluate Zenith Alpha Abdominal Stent Graft for Abdominal Aortic Aneurysm (JUSTICE) Registry Demonstrate Acceptable Limb Patency at 12 Months
No full textSupplemental material, sj-tiff-3-jet-10.1177_15266028241248311 for Early Clinical Results From the Japanese Prospective Multicenter Study to Evaluate Zenith Alpha Abdominal Stent Graft for Abdominal Aortic Aneurysm (JUSTICE) Registry Demonstrate Acceptable Limb Patency at 12 Months by Naoki Fujimura, Shigeo Ichihashi, Tsuyoshi Shibata, Hitoshi Matsumura, Michiko Watanabe, Noriyasu Morikage, Yoshihiko Kurimoto, Hiroshi Banno, Hidetoshi Uchiyama and Hideaki Obara in Journal of Endovascular Therapy</p
sj-docx-1-jet-10.1177_15266028241248311 – Supplemental material for Early Clinical Results From the Japanese Prospective Multicenter Study to Evaluate Zenith Alpha Abdominal Stent Graft for Abdominal Aortic Aneurysm (JUSTICE) Registry Demonstrate Acceptable Limb Patency at 12 Months
No full textSupplemental material, sj-docx-1-jet-10.1177_15266028241248311 for Early Clinical Results From the Japanese Prospective Multicenter Study to Evaluate Zenith Alpha Abdominal Stent Graft for Abdominal Aortic Aneurysm (JUSTICE) Registry Demonstrate Acceptable Limb Patency at 12 Months by Naoki Fujimura, Shigeo Ichihashi, Tsuyoshi Shibata, Hitoshi Matsumura, Michiko Watanabe, Noriyasu Morikage, Yoshihiko Kurimoto, Hiroshi Banno, Hidetoshi Uchiyama and Hideaki Obara in Journal of Endovascular Therapy</p
Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
No full textApo E plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface LDL receptor. In the present study, we studied the effects of apo E on the atherogenic process in Watanabe heritable hyperlipidemic rabbits which are deficient in LDL receptor and an animal model for familial hypercholesterolemia. We isolated apo E from plasma of 1% cholesterol-fed rabbits and administered 10 mg of purified apo E intravenously into five Watanabe heritable hyperlipidemic rabbits three times a week from their age of 2.5 months to 11 months for 8.5 months. After sustained administration to apo E, we found a significant reduction in the accumulation of cholesterol ester in aortae (1.55 +/- 0.07 mg/g tissue) as compared to control rabbits (4.32 +/- 0.61 mg/g tissue). Supporting this, the percentage of the surface area of the aorta with macroscopic plaque was remarkably decreased in apo E-treated animals (18.8 +/- 5.1% vs. 38.8 +/- 8.0% in control). Thus, apo E definitely prevented the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits
SGLT2阻害剤の肝糖新生応答制御に対する食事量制限の重要性
No full text金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Diabetes Investigation 12(1) pp.35-47 2021. Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. 共著者：Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Michihiro Matsumoto, Hiroshi Inoue, Yuka Inabadoctoral thesi
SGLT2阻害剤の肝糖新生応答制御に対する食事量制限の重要性
No full text博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Diabetes Investigation 12(1) pp.35-47 2021. Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. 共著者：Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Michihiro Matsumoto, Hiroshi Inoue, Yuka Inab
Gadd34 regulates liver regeneration in hepatic steatosis
No full text博士論文要旨Abstract 要約Outline 以下に掲載：HEPATOLOGY 61(4) pp.1343-1356 2015. John Wiley and Sons. 共著者：Yuka Inaba, Tomoko Furutani, Kumi Kimura, Hitoshi Watanabe, Sanae Haga, Yoshiaki Kido, Michihiro Matsumoto, Yasuhiko Yamamoto, Kenichi Harada, Shuichi Kaneko, Seiichi Oyadomari, Michitaka Ozaki, Masato Kasuga, Hiroshi Inou
Control Precision in the Flaking of Levallois Points from the Amud Cave ; A Technological Approach to the Study of Early Man's Manual Dexterity
No full textSpecimens used for this analysis are Levallois flake of a special type, i.e. pointed flakes with a central scar on the upper surface which belong to a transitional (Middle I Upper) Palaeolithic industry from the Amud Cave, Israel. The analysis was made to assess quantitatively and objectively the flaking skill in terms of the uniformity of thickness and the central scar-bulbar surface parallelism which are regarded as reflecting the precision of manual control.RÉSUMÉ Série de mesures sur des éclats levallois d'un certain type, éclats pointus avec enlèvement central sur la face supérieure qui appartiennent à l'industrie de transition entre la paléolithique moyen et supérieur de la grotte de l'Amud (Israel). Le but de cette analyse est de mettre en évidence avec objectivité et de façon quantitative la dextérité manifestée lors du débitage. L'uniformité dans l'épaisseur de l'éclat et le parallélisme entre ses deux plans sont les facteurs considérés comme reflétant la précision du contrôle manuel.Watanabe Hitoshi, Kuchikura Yukio. Control Precision in the Flaking of Levallois Points from the Amud Cave ; A Technological Approach to the Study of Early Man's Manual Dexterity. In: Paléorient, 1973, vol. 1, n°1. pp. 87-95
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