1,720,974 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Glutathione peroxidase 8: transcriptional regulation and role in growth factor signaling
Full text linkDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Die Rolle des Hypoxie-induzierbaren Lipidtropfenproteins Hig2/Hilpda bei der Entstehung der Atherosklerose
Full text linkHypoxia-inducible factors are essential transcription factors in the cellular and systemic adaption to oxygen deficiency. Under hypoxia they induce the expression of thousands of target genes, among them a group of ubiquitously expressed genes responsible for the metabolic adaption to reduced oxygen availability. One of the direct Hif target genes is hypoxia-inducible protein Hig2/Hilpda which was identified as a ubiquitously expressed hypoxia-inducible lipid droplet protein. Hilpda was detected in human atherosclerotic plaques. However, it was unknown whether Hilpda plays a role in hypoxic lipid accumulation in atherosclerotic foam cells.
In the present study we therefore further analyzed the regulation and functional role of Hilpda in primary murine wild type and hilpda deficient bone marrow-derived macrophages and in an atherosclerotic mouse model with conditional hilpda deletion. We could show that Hilpda is a direct Hif-1 and Ppar target gene. Hilpda was essential for the storage of triglycerides, cholesterylesters and oxLDL in lipid droplets. Hilpda-deficient macrophages were not able to form lipid droplets and were less resistant to stress by fatty acid overload. Moreover, Hilpda was essential for a controlled and inducible PGE2 production.
Analysis of the atherosclerotic mouse model (apoE-/-) with tie2-Cre mediated hilpda deletion showed that Hilpda-induced lipid accumulation is involved in foam cell formation and development of atherosclerosis, but does not alter serum-lipid concentrations. Hilpda co-localized with Cox-2 in murine and human plaques, indicating a role in PGE2 production. (Immuno-)histochemical analyses showed less macrophages and increased numbers of untransformed smooth muscle cells in plaques of Hilpda-deficient mice. Expression analyses of large arteries of high-fat diet-fed mice showed decreased expression of fabp4, mpges-1 and vegf mRNA in apoE / hilpda tie2-Cre knockout mice.
Thus, the hypoxia-inducible lipid droplet protein Hilpda is crucial to different forms of lipid accumulation in macrophages and protects from membrane damage through fatty acid overload. In atherosclerosis Hilpda is involved in formation of foam cells and PGE2 production and therefore promotes lesion formation and probably progression of atherosclerosis.Die Hypoxie-induzierbaren Faktoren sind essenzielle Transkriptionsfaktoren bei der zellulären und systemischen Anpassung an Sauerstoffmangel. Unter Hypoxie induzieren sie die Expression tausender Zielgene, von denen eine Gruppe an der Anpassung des Metabolismus an eine reduzierte Verfügbarkeit von Sauerstoff beteiligt ist. Ein direktes Hif-Zielgen ist auch das Hypoxie-induzierbare Protein Hig2/Hilpda, welches als ubiquitär exprimiertes, Hypoxie-induzierbares Lipidtropfenprotein identifiziert wurde. Hilpda wurde in humanen atherosklerotischen Plaques detektiert. Inwieweit Hilpda zur hypoxischen Lipidakkumulation in atherosklerotischen Schaumzellen beiträgt, war noch nicht bekannt.
In der vorliegenden Arbeit wurden daher die Regulation und die funktionelle Rolle von Hilpda in primären murinen Wildtyp und hilpda-defizienten Knochenmarksmakrophagen und in einem Mausmodell für Atherosklerose mit konditioneller hilpda-Deletion genauer untersucht. Wir konnten zeigen, dass Hilpda in murinen Makrophagen ein Hif-1- und ein Ppar-Zielgen ist. Hilpda war notwendig für die Speicherung von Triglyceriden, Cholesterinestern und oxLDL in Lipidtropfen. In hilpda-defizienten Makrophagen war eine Lipidtropfenbildung nicht möglich. Hilpda cKO Makrophagen waren weniger resistent gegenüber Stress durch Fettsäure-Überladung. Des Weiteren war Hilpda notwendig für eine kontrollierte und induzierbare Produktion von PGE2.
Untersuchungen am Apolipoprotein E-defizienten Mausmodell für Atherosklerose mit tie2-Cre gesteuerter hilpda-Deletion zeigten, dass die durch Hilpda induzierte Lipidakkumulation zur Bildung von Schaumzellen und zur Entstehung der Atherosklerose beiträgt, die Serum-Lipidkonzentrationen aber nicht beeinflusst. Hilpda kolokalisierte mit Cox-2 in murinen und humanen Plaques, was auf eine Rolle bei der PGE2-Produktion hinweist. (Immun ) histochemische Analysen zeigten weniger Makrophagen und vermehrt untransformierte Gefäßmuskelzellen in Plaques Hilpda-defizienter Mäuse. In Expressionsanalysen von großen Arterien fettgefütterter Mäuse war die, fabp4, mpges-1 und vegf mRNA Expression in apoE-/- hilpda tie2-Cre Knockout Mäusen erniedrigt.
Hilpda ist also essenziell für verschiedene Arten der Lipidspeicherung in Makrophagen und schützt diese vor Membranschäden durch Fettsäure-Überladung. Bei Atherosklerose ist Hilpda an der Entstehung von Schaumzellen und der Produktion von PGE2 beteiligt und trägt dadurch zur Atherogenese und wahrscheinlich zur Progression der Atherosklerose bei
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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