542 research outputs found
William of Peter of Godin and the Quaestio utrum essentiae rerum creatarum sint ab aeterno (Wien, Österreichische Nationalbibliothek, ms. 1590)
No full textUn’analisi approfondita della tradizione manoscritta relativa al secondo li- bro della Lectura Thomasina di Guglielmo di Pietro di Godino (†1336) met- te in luce alcune significative varianti contenute nel manoscritto di Vienna (Österreichische Nationalbibliothek ms. 1590). In modo particolare la prima questione risulta essere differente rispetto a quella trasmessa dagli altri testi- moni: in effetti, laddove essi riportano circa primam distinctionem secundi libri qua- eritur primo utrum mundus possit fuisse ab aeterno, il copista di Vienna scrive quaestio prima est utrum essentiae rerum creatarum sint ab aeterno. Osservando somiglianze e differenze tra i due testi, questo studio tenta di stabilire se Godino sia effettivamente l’autore della quaestio prima di Vienna e se quest’ultima possa essere con- siderata una redazione alternativa del testo trasmesso dagli altri manoscritti.An in-depth analysis of all manuscripts preserving the second book of the Lec- tura Thomasina of the Dominican theologian William of Peter of Godin (†1336) reveals significant variants in Vienna manuscript (Österreichische National- bibliothek ms. 1590). In particular, the first question turns out to be different from the others: whereas all other manuscripts have circa primam distinctionem secundi libri quaeritur primo utrum mundus possit fuisse ab aeterno, the copyist of Vienna writes quaestio prima est utrum essentiae rerum creatarum sint ab aeterno. By comparing these two texts from different points of view, the study attempts to establish whether William of Peter of Godin is effectively the author of the text copied in the Vienna manuscript and whether this text can be included in the Lectura Thomasina’s manuscript tradition as alternative redaction
Acute oxygen therapy: a review of prescribing and delivery practices
No full textJoyce L Cousins,1–3 Peter AB Wark,3–5 Vanessa M McDonald2–5 1Faculty of Arts, Nursing and Theology, Avondale College of Higher Education, Sydney, 2School of Nursing and Midwifery, 3Priority Research Centre for Healthy Lungs, 4School of Medicine and Public Health, The University of Newcastle, 5Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia Abstract: Oxygen is a commonly used drug in the clinical setting and like other drugs its use must be considered carefully. This is particularly true for those patients who are at risk of type II respiratory failure in whom the risk of hypercapnia is well established. In recent times, several international bodies have advocated for the prescription of oxygen therapy in an attempt to reduce this risk in vulnerable patient groups. Despite this guidance, published data have demonstrated that there has been poor uptake of these recommendations. Multiple interventions have been tested to improve concordance, and while some of these interventions show promise, the sustainability of these interventions are less convincing. In this review, we summarize data that have been published on the prevalence of oxygen prescription and the accurate and appropriate administration of this drug therapy. We also identify strategies that have shown promise in facilitating changes to oxygen prescription and delivery practice. There is a clear need to investigate the barriers, facilitators, and attitudes of clinicians in relation to the prescription of oxygen therapy in acute care. Interventions based on these findings then need to be designed and tested to facilitate the application of evidence-based guidelines to support sustained changes in practice, and ultimately improve patient care. Keywords: chronic obstructive pulmonary disease, COPD, type II respiratory failure, oxygen therapy, prescribing, hypoxia, hypercapni
Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD
No full textNetsanet A Negewo,1,2 Peter G Gibson,1–3 Peter AB Wark,1–3 Jodie L Simpson,1,2 Vanessa M McDonald1–4 1Priority Research Centre for Healthy Lungs, 2Hunter Medical Research Institute, Faculty of Health and Medicine, The University of Newcastle, Callaghan, 3Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, 4School of Nursing and Midwifery, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia Background: COPD patients are often prescribed multiple medications for their respiratory disease and comorbidities. This can lead to complex medication regimens resulting in poor adherence, medication errors, and drug–drug interactions. The relationship between clinical outcomes and medication burden beyond medication count in COPD is largely unknown.Objectives: The aim of this study was to explore the relationships of medication burden in COPD with clinical outcomes, comorbidities, and multidimensional indices.Methods: In a cross-sectional study, COPD patients (n=222) were assessed for demographic information, comorbidities, medication use, and clinical outcomes. Complexity of medication regimens was quantified using the validated medication regimen complexity index (MRCI).Results: Participants (58.6% males) had a mean (SD) age of 69.1 (8.3) years with a postbronchodilator forced expiratory volume in 1 second % predicted of 56.5 (20.4) and a median of five comorbidities. The median (q1, q3) total MRCI score was 24 (18.5, 31). COPD-specific medication regimens were more complex than those of non-COPD medications (median MRCI: 14.5 versus 9, respectively; P<0.0001). Complex dosage formulations contributed the most to higher MRCI scores of COPD-specific medications while dosing frequency primarily drove the complexity associated with non-COPD medications. Participants in Global Initiative for Chronic Obstructive Lung Disease quadrant D had the highest median MRCI score for COPD medications (15.5) compared to those in quadrants A (13.5; P=0.0001) and B (12.5; P<0.0001). Increased complexity of COPD-specific treatments showed significant but weak correlations with lower lung function and 6-minute walk distance, higher St George’s Respiratory Questionnaire and COPD assessment test scores, and higher number of prior year COPD exacerbations and hospitalizations. Comorbid cardiovascular, gastrointestinal, or metabolic diseases individually contributed to higher total MRCI scores and/or medication counts for all medications. Charlson Comorbidity Index and COPD-specific comorbidity test showed the highest degree of correlation with total MRCI score (ρ=0.289 and ρ=0.326; P<0.0001, respectively).Conclusion: In COPD patients, complex medication regimens are associated with disease severity and specific class of comorbidities. Keywords: medication burden, medication counts, complex pharmacotherapy, clinical scores 
Hopp, trots allt
No full textThis article discusses the German-Swedish author Peter Weiss and his book "Die Ästhetik des Widerstandes" (The Aesthetic of Resistance), and argues for hope, after all
The role of exhaled nitric oxide and exhaled breath condensates in evaluating airway inflammation in asthma
No full textAB-INITIO INVESTIGATION OF TERAHERTZ VIBRATIONAL MODES IN MOLECULAR CRYSTALS
No full textS. J. Clark, et al., Z. Kristallographie 220,P. Uhd Jepsen and S. J. Clark, Chem. Phys. Lett. 442,Author Institution: Department of Photonics Engineering, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark; Department of Physics, University of Durham, Durham DH1 3LE, United KingdomWe use the CASTEP ab-initio density-functional perturbation theory code} 567 (2005)} to investigate the properties of terahertz-frequency vibrational modes in crystalline systems. We will discuss the strong mixing of molecular and phonon modes in hydrogen-bonded crystals} 275 (2007)}, and also discuss ongoing work where we study nonlinear interaction between intense THz light and molecular crystals
Anselm of Canterbury and the Development of Theological Thought, c. 1070-1141
No full textThis thesis explores the role of Anselm of Canterbury (1033-1109) in the development of theological thought in the late eleventh and early twelfth centuries. It aims to demonstrate that Anselm’s thought had a greater impact on the early development of scholastic theology than is often recognized, particularly in the areas of the doctrine of the incarnation and redemption, but also in his discussion of freedom and sin. Through his explanation of the economy of salvation in terms of making satisfaction for sin, and his rejection of modes of discussion that focussed on the rights and role of the devil, Anselm’s writing on the theology of the redemption provided a framework for the discussion of later authors such as Hugh of St Victor, Peter Abelard, Bernard of Clairvaux and authors associated with the School of Laon, among others. Such discussion often utilized Anselm as an explicator of difficult passages in patristic theology, notably Augustine, and his work was most controversial when he was thought to have contradicted earlier authority. Anselm was involved in contemporary polemics with both Jews and Christian theologians, as well as producing works that explored profound theological and metaphysical ideas. In his emphasis on the place and role of reason in divine questions, he crossed the boundaries between ‘monastic’ and ‘scholastic’ thought. Through an exploration of Anselmian elements in the thought of a variety of authors from the late eleventh and early twelfth centuries, this thesis aims to contribute to a broadening understanding of the legacy of this great thinker
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