84,646 research outputs found
Designing 21st Century Standard Ware: The Cultural Heritage of Leach and the Potential Applications of Digital Technologies
No full textThis practice-based research investigates the potential applications of digital manufacturing technologies in the design and production of hand-made tableware at the Leach Pottery. The methodology for the research establishes an approach grounded in my previous experience as a maker that is informed by an open, experimental, emergent, and responsive framework based on Naturalistic Inquiry.
A critical contextual review describes the cultural heritage of Leach which, for the purposes of the research, is developed through the Leach Pottery as a significant site, the historical production of the iconic Leach Standard Ware and the contemporary production of Leach Tableware. This is followed by an examination of Potter’s Tools in the Leach production environment, and a review of makers’ digital ceramic practice.
The contextual review is followed by an explication of ‘standards’ presented through visual lineages of Standard Ware and Leach Tableware to define ‘standard’ at a design (macro) level, followed by an examination of how ‘standard’ operates at a making (micro level) level. This chapter presents new knowledge in relation to defining the visual field of Leach Pottery tableware production and its standards of design.
A chapter focussed on practice presents the outcomes and analysis of my engagement with digital manufacturing technologies which resulted in the development of new tools to support Leach Tableware production and the interrogation of Leach forms, in different mediums, which led to the creation of Digital-Analogue Leach forms. The practice culminated in the design and development of new 21st century Standard Ware: a range of 9 forms, called Echo of Leach, that were developed by myself using digital and analogue methods: the designs were realised by myself, the Leach Studio, and a further four makers. The outcomes of the research were presented in a three month exhibition at the Leach Pottery in 2013.
The conclusions of the research draw on the key points raised in the analysis of the practice and relate these to the approaches to making pottery that are highlighted in the cultural heritage of Leach in the contextual review. These are also discussed in relation to ways in which these findings could be taken forward into development of knowledge about Standard Ware, especially in a broader studio pottery context
History of Mendon : A Pioneer Chronicle of a Mormon Settlement by Isaac Sorensen
No full textHistory of Mendon : A Pioneer Chronicle of a Mormon Settlement by Isaac Sorensen. Also called Isaac Sorensen's History of Mendon. Edited by Doran J. Baker, Charles S. Peterson, Gene A. Ware ; introduction by Charles S. Peterson ; photographic galleries by Richard B. Watkins, Paul R. Willie.
Distributions of fluorescence decay times for parinaric acids in phospholipid membranes
No full textPT: J; CR: BLATT E, 1985, BIOCHIM BIOPHYS ACTA, V822, P43 CHEN LA, 1977, J BIOL CHEM, V252, P2163 DEVAUX PF, 1985, BIOCHIM BIOPHYS ACTA, V822, P63 FUNG BKK, 1978, BIOCHEMISTRY, V17, P5341 GALLAY J, 1986, BIOCHEMISTRY-US, V25, P2650 JAMES DR, 1985, CHEM PHYS LETT, V120, P450 JAMES DR, 1986, CHEM PHYS LETT, V126, P7 KARNOVSKY MJ, 1982, J CELL BIOL, V97, P73 KAWATO S, 1977, BIOCHEMISTRY-US, V16, P2319 KLAUSNER RD, 1980, J BIOL CHEM, V255, P1286 LAKOWICZ JR, 1985, BIOCHEMISTRY-US, V24, P376 PARASASSI T, 1984, BIOCHEMISTRY-US, V23, P5660 PETERSEN NO, 1987, CAN J CHEM, V65, P238 ROSS JBA, 1981, BIOCHEMISTRY-US, V20, P4369 SKLAR LA, 1977, BIOCHEM, V16, P813 VINCENT M, 1984, BIOCHEMISTRY-US, V23, P6514 WARE WR, 1983, REV SCI INSTRUM, V54, P1148 WOLBER PK, 1981, BIOCHEMISTRY-US, V20, P2800 YGUERABIDE J, 1981, MOL BIOL BIOCH BIOPH, V31, P199; NR: 19; TC: 38; J9: BIOCHEMISTRY-USA; PG: 6; GA: K2107Source type: Electronic(1
Modeling and measurements of rainfall by ground-based multispectral microwave radiometry
No full textAbstract—The potential of ground-based multispectral microwave
radiometers in retrieving rainfall parameters is investigated
by coupling physically oriented models and retrieval methods
with a large set of experimental data. Measured data come from
rain events that occurred in the USA at Boulder, Colorado, and
at the Atmospheric Radiation Measurement (ARM) Program’s
Southern Great Plains (SGP) site in Lamont, OK. Rain cloud
models are specified to characterize both nonraining clouds,
stratiform and convective rainfall. Brightness temperature numerical
simulations are performed for a set of frequencies from
20 to 60 GHz at zenith angle, representing the channels currently
deployed on a commercially available ground-based radiometric
system. Results are illustrated in terms of comparisons between
measurements and model data in order to show that the observed
radiometric signatures can be attributed to rainfall scattering
and absorption. A new statistical inversion algorithm, trained by
synthetic data and based on principal component analysis is also
developed to classify the meteorological background, to identify the
rain regime, and to retrieve rain rate from passive radiometric observations.
Rain rate estimate comparisons with simultaneous rain
gauge data and rain effect mitigation methods are also discussed
Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente
No full textTumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts. Signaling by the lymphotoxin (LT)-beta receptor or TNF receptor-1, but not Fas or TRAIL receptors, inhibits the cytopathicity and replication of human CMV by a nonapoptotic, reversible process that requires nuclear factor kappa B (NF-kappa B)-dependent induction of interferon-beta (IFN-beta). Efficient induction of IFN-beta requires virus infection and LT signaling, demonstrating the need for both host and viral factors in the curtailment of viral replication without cellular elimination. LT alpha-deficient mice and LT beta R-Fc transgenic mice were profoundly susceptible to murine CMV infection. Together, these results reveal an essential and conserved role for LTs in establishing host defense to CMV
Forecasting banknotes
No full textA central bank’s liquidity forecast is important in ensuring that it supplies the banking system’s need for central bank money. Banknote (or currency in circulation) demand is the largest and for some central banks the most variable component of the liquidity forecast. Accurate forecasting of banknotes is essential in ensuring an accurate liquidity forecast and in turn effective monetary policy implementation. This Handbook discusses these issues and outlines a structural time series state space (STSSS) model which is now used by central banks including the Bank of England and ECB to forecast banknotes (currency in circulation).Forecasting banknotes
Model based defect characterization in composites
No full textWork is reported on model-based defect characterization in CFRP composites. The work utilizes computational models of the interaction of NDE probing energy fields (ultrasound and thermography), to determine 1) the measured signal dependence on material and defect properties (forward problem), and 2) an assessment of performance-critical defect properties from analysis of measured NDE signals (inverse problem). Work is reported on model implementation for inspection of CFRP laminates containing multi-ply impact-induced delamination, with application in this paper focusing on ultrasound. A companion paper in these proceedings summarizes corresponding activity in thermography. Inversion of ultrasound data is demonstrated showing the quantitative extraction of damage properties.This proceeding may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.
This proceeding appeared in Roberts, R., and S. Holland. "Model based defect characterization in composites." In AIP Conference Proceedings, vol. 1806, no. 1, p. 090015. AIP Publishing LLC, 2017, and may be found at
DOI: 10.1063/1.4974659.
Copyright 2017 Author(s).
Posted with permission
Automating quantitative measures of an established conventional MRI scoring system for preterm-born infants scanned between 29 to 47 weeks' postmenstrual age.
No full textBackground and Purpose: Conventional MRI scoring is a valuable tool for risk stratification and prognostication of outcomes, but manual scoring is time-consuming, operator-dependent, and requires high-level expertise. This study aims to automate the regional measurements of an established brain MRI scoring system for preterm neonates scanned between 29-47 weeks post-menstrual age (PMA).
Materials and Methods: This study used T2WI from the longitudinal Prediction of PREterm Motor Outcomes cohort study (PPREMO) and developing Human Connectome Project. Measures of biparietal width, interhemispheric distance, callosal thickness, transcerebellar diameter, lateral ventricular diameter, and deep grey matter area were extracted manually (PPREMO only) and automatically. Scans with poor quality, failure of automated analysis, or severe pathology were excluded. Agreement, reliability, and associations between manual and automated measures were assessed, and compared against statistics for manual measures. Associations between measures with PMA, gestational age at birth (GA), and birth weight were examined (Pearson’s correlation) in both cohorts.
Results: 652 MRIs (86%) were suitable for analysis. Automated measures showed good to excellent agreement and good reliability with manual measures, except for interhemispheric distance at early MRI (scanned between 29-35 weeks PMA; in line with poor manual reliability) and callosal thickness measures. All measures were positively associated with PMA (r=0.11-0.94; R2=0.01-0.89). Negative and positive associations were found with GA (r=-0.26-0.71; R2=0.05-0.52), and birth weight (r=-0.25-0.75; R2=0.06-0.56). Automated measures were successfully extracted for 80-99% of suitable scans.
Conclusion: Measures of brain injury and impaired brain growth can be automatically extracted from neonatal MRI, which could assist with clinical reporting
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Infant massage and brain maturation measured using EEG: A randomised controlled trial
No full textBackground: Very preterm (VPT) infants develop adverse neurological sequelae from early exposure of the immature brain to the extrauterine environment.Aims: To determine the effects of infant massage on brain maturation in low-risk VPT infants.Study design: A randomised controlled trial of VPT infants, who received standard care or daily massage therapy, administered by the mother, from 34 weeks' to 40 weeks' corrected age (CA). Subjects: VPT infants (born at 28 weeks to 32 + 6 weeks' gestational age, G.A.) and a healthy at term cohort for comparison.Outcome measures: At term equivalent age (39 weeks' to 42 weeks' CA), EEG was recorded to calculate global relative power (GRP), using power spectral analysis.Results: Sixty infants were recruited, and EEGs of 25 massage and 20 standard care infants were analysable. There was no difference between groups in primary outcome (beta GRP). There was a significantly higher central alpha relative power measured in the intervention group infants, compared to standard care (SC) group (mean dif-ference = 1.42, 95 % confidence interval (CI): 0.12 to 2.73; p = 0.03). A massage dose effect was shown by a positive correlation between, massage dose and beta, alpha and theta GRP (r = 0.42, 95%CI = 0.12 to 0.64, r = 0.45; 95%CI = 0.16 to 0.66, r = 0.39; 95%CI = 0.10 to 0.62 respectively) and a negative correlation between massage dose and delta GRP (r =-0.41, 95%CI =-0.64 to-0.12), suggesting that a higher dose of massage is associated with more favourable brain maturation.Conclusions: Central alpha regional relative power was greater in massaged infants compared to SC group infants, suggesting relatively greater brain maturation in this area. A measurable massage dose effect in favour of greater brain maturation, shows promise for verification in a larger clinical trial
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