21 research outputs found
Dinamika Hasil Air dan Analisis Nilai Ekonomi Sumber Daya Air Daerah Aliran Sungai (DAS) Kuranji
No full textPerubahan penggunaan lahan merupakan penyebab utama tingginya runoff di DAS Kuranji dan telah menimbulkan dampak sosial dan ekonomi masyarakat. Mengingat permasalahan DAS Kuranji merupakan masalah yang kompleks, maka tidak bisa dikaji dengan satu pendekatan ilmu saja. Penelitian ini bertujuan untuk mengetahui dinamika hasil air DAS, nilai ekonomi yang muncul dari upaya konservasi DAS dan merumuskan arahan dan rekomendasi pengelolaan DAS Kuranji. Dinamika hasil air DAS Kuranji di-analisa berdasarkan model hidrologi SWAT. Metode Willingness to pay (WTP) digunakan untuk mengetahui nilai ekonomi yang muncul dari skenario upaya konservasi lahan kritis dalam DAS Kuranji melalui pendekatan nilai penawaran (bid) dari harga air. Hasil penelitian menunjukkan nilai dinamika hasil air DAS Kuranji adalah : kehandalan 0,79 dengan lama kejadian 290 hari dalam setahun, nilai kelentingan 0,67 atau 67 % kepastian keberhasilan DAS untuk kembali dalam kondisi normal dengan lama kepulihan 75 hari dalam setahun serta rata – rata kerusakan DAS adalah 389.466 m3/hari. Nilai ekonomi sumber daya air yang muncul dalam upaya konservasi DAS Kuranji adalah Rp 272/m3 air yang hanya mampu mengkonservasi 80 % lahan kritis DAS Kuranji. Arahan dan rekomendasi pengelolaan DAS Kuranji adalah menumbuhkan kesadaran masyarakat melalui pembentukan persepsi masyarakat, konservasi tepat sasaran, konservasi DAS secara kontiniu, pemberdayaan masyarakat dan kebijakan insentif yang mengatur pembayaran jasa lingkungan.
Kata kunci : DAS Kuranji, Dinamika Hasil air, Konservasi, Lahan Kritis, Willingness to pay (WTP
ANALISIS KESESUAIAN LAHAN UNTUK PENGEMBANGAN TANAMAN KAYU MANIS (Cinnamomum burmanii BL.) DI KABUPATEN SOLOK SELATAN
No full textSektor pertanian memegang peranan penting dalam perekonomian Indonesia, seperti subsektor perkebunan. Salah satu tanaman perkebunan yang mempunyai nilai ekonomis tinggi di Indonesia adalah tanaman kayu manis (Cinnamomum burmanii BL.). Selain itu, tanaman kayu manis juga dapat berfungsi sebagai tanaman penghijauan dan konservasi lahan, khususnya di tebing – tebing dan kaki pegunungan serta daerah aliran sungai. Kabupaten Kerinci dan Merangin di Provinsi Jambi merupakan penghasil kayu manis nomor tiga di dunia. Kabupaten Solok Selatan merupakan salah satu daerah yang terletak di Provinsi Sumatera Barat yang berbatasan langsung dengan Kabupaten Kerinci Provinsi Jambi. Kabupaten Solok Selatan memiliki karakteristik iklim dan topografi yang hampir sama dengan Kabupaten Kerinci. Oleh karena itu, tanaman kayu manis bisa dikembangkan di Kabupaten Solok Selatan dengan memperhatikan kesesuaian lahan yang ada. Tujuan dari penelitian ini adalah untuk mengetahui kesesuaian lahan tanaman kayu manis di Kabupaten Solok Selatan dalam upaya pengembangan tanaman kayu manis di Kabupaten Solok Selatan. Berdasarkan hasil penelitian diperoleh lahan tersedia untuk pengembangan tanaman kayu manis seluas 86.430,15 ha atau 24,07 % dan lahan tidak tersedia seluas 272.574,72 ha atau 75,93 %. Setelah dilakukan overlay terhadap masing - masing parameter kesesuaian lahan tanaman kayu manis (curah hujan, jenis tanah, temperature, dan kelerengan), maka didapatkan lahan kelas S1 (Sangat Sesuai) seluas 24.775,00 ha atau 6,90 %, lahan kelas S2 (Cukup Sesuai) seluas 61.598,04 ha atau 17,16 % dan lahan kelas S3 (Sesuai Marginal) 57,11 ha atau 0,07 %. Analisis Produksi tanaman kayu manis dari lahan tersedia menghasilkan 1.209.225,56 ton kulit kering dalam rentang waktu 8 tahun pembudidayaan dengan harga Rp. 24.184.511.200.
Kata Kunci : kayu manis, kesesuaian lahan, Kabupaten Solok Selata
SIMULASI KONSERVASI LAHAN KRITIS TERHADAP HASIL AIR (WATER YIELD) DAERAH ALIRAN SUNGAI (DAS) KURANJI MENGGUNAKAN MODEL SWAT (SOIL AND WATER ASSESMENT TOOL)
No full textPerubahan iklim dan penggunaan lahan memiliki dampak yang besar terhadap keseimbangan air. Perubahan penggunaan lahan merupakan penyebab utama tingginya run off dibandingkan dengan faktor lainnya. Bencana alam yang terjadi di wilayah DAS (Daerah Aliran Sungai) merupakan indikasi bahwa fungsi hidrologi di wilayah DAS dalam keadaan terganggu dan tidak dapat mendukung sistem tata air yang optimal. Hampir setiap tahun terjadi banjir di kawasan DAS Kuranji yang menimbulkan kerugian secara materil dan korban jiwa. Salah satu bentuk upaya untuk menjaga kelestarian DAS adalah dengan melakukan konservasi pada wilayah – wilayah yang memberikan dampak buruk terhadap DAS seperti lahan kritis. Tujuan penelitian ini adalah mensimulasikan konservasi lahan kritis DAS Kuranji terhadap perubahan hasil air. Simulasi dilakukan terhadap 3 skenario penggunaan lahan yaitu konservasi 50 %, 80 % dan 100 % terhadap luas lahan kritis. Hasil penelitian menunjukkan bahwa terdapat 818,92 ha lahan kritis yang bisa digunakan untuk lahan konservasi. Simulasi perubahan penggunaan lahan terhadap lahan kritis dari beberapa skenario menunjukkan bahwa skenario konservasi 100 % menunjukkan kondisi hidrologi yang lebih baik. Artinya, semakin luas lahan yang di konservasi menjadi hutan campuran maka akan menurunkan hasil air, sehingga menurunkan aliran permukaan dan menaikkan volume air tanah DA
Road to Universal Health Coverage 2030: Health Financing for Maternal and Child Health among East African Community Countries, what they do and what they achieved. A scoping Review.
No full text
Road to Universal Health Coverage 2030: Health Financing for Maternal and Child Health in East African Community Member Countries-What they do and what they achieved. A Scoping Review.
1.The Study Aim;
The aim of this study is to explore health financing strategies used by each EAC country to achieve Universal health coverage for Maternal and child health. Secondly, to examine the progress made towards attaining universal health coverage for maternal and child health by 2030.
2. The study Objectives.
2.1 General Objective, To examine health financing strategies and their impacts on achieving Universal health coverage for maternal and child health among East African member community countries.
2.2. Specific Objective.
2.2.1. To explore health systems financing strategies for maternal and child health coverage among the East African Community member countries.
2.2.2 To compare progress in maternal and child health indicators and link them to the health financing strategies on improved access, utilization, quality of care and benefits package (Antenatal Care, Institutional Delivery, Postnatal care, vaccinations) to see whether these have contributed to reducing maternal and under 5 mortality.
2.2.3. To formulate recommendations based on best performing practices of health financing strategies on maternal and child health outcomes for South Sudan.
3.Methods and Study Design.
A scoping review methodology approach was used to synthesize relevant evidence of information on the study topic based on the study objectives. The Joanna and Briggs Institute (JBI) methodology approach to scoping reviews written by Peters et al.58 (2020) version was used to explore and synthesize evidence across the existing body of literature.58 The steps described in the JBI include selecting a study topic, obtaining sources of information, designing a search strategy, charting data, extracting findings and reporting the results. Accordingly, this study used the description of Participant, Concept and Context (PCC) approach to evidence synthesis. The Participant refers to the state as the health financing and governing entity in individual EAC Countries. The Concept being strategies of Health systems financing targeting MCH and the Context being the East African Community countries (Table 1 Below). The hypothesis behind the study questions is Healthcare Financing strategies aimed at improving access, utilization , quality and affordability of MCH care may translate into improved coverage and reduction in maternal and child mortality.
Table 2 The PCC framework, characteristics and Justification.
The PCC Framework
Characteristic
Justification
Participant
The state as health actor
of each country.
Obligations and commitments to UHC, SDGs,
and EAC ’s Common health Agenda Vision 2050.
Concepts
Strategies for Health systems Financing for maternal and child health.
Complexities in financing approaches employed by each country for maternal and child health coverage.
Varying levels of Maternal and child health indicators.
Context
East African Community
Countries.
Common vision and goals on maternal and child health agenda as a regional block.
3.1 Study Questions.
I formulated the research questions according to the PCC frame work and in line with the study objectives as follows;
1. What health financing strategies are used by EAC states to achieve Universal health coverage for maternal and child health?
2. What impact did these strategies have on reduction in maternal and Under 5 mortality?
3. How and why did these strategies lead to impacts in maternal and Under 5 mortality?
3.2 Identification of Literature Sources.
3.2.1. Literature Search Strategy.
The study was based on information gathered from existing published and unpublished literature sources including policy documents from respective EAC states. I made searches on three sets of databases; PubMed, Global Health database, Web of Science and Google search to obtain relevant literature to the study questions. Google search was used to obtain online unpublished literature including policy documents from EAC state government websites and international organizations like WHO, WB, UNICEF, UN websites of respective EAC countries
3.2.2 Inclusion Criteria.
The selection process began with screening the titles and abstracts of the articles from the databases. The study papers considered in the search included both primary and secondary articles. The study included qualitative, quantitative and review articles with varying study designs. Searches were made for articles published in English for the EAC Countries and were limited to 10 years duration from 1st January 2013 to the final search date on 6th April 2023.
Box 1. Inclusion Criteria.
- Paper type; Primary, secondary, peer review papers.
- Type of literature; Published and grey literature, policy documents, thesis, books, reports, webpages.
- Period of Publication-from January 01, 2013 to April 06,2023.
- Language- Articles published in English.
- Health systems and policy documents with focus on maternal and child health.
2.
3.4.3 Exclusion Criteria.
Excluded were those articles that didn’t mention health financing strategies or Universal health coverage specific for Maternal and child health. Articles that involved health care financing for specified disease conditions other than in pregnancy or Maternal and child health care were excluded. Also, articles published in languages other than English were not included. This was due to the challenge of word translations and the interpretations that came with other languages. Articles published before January 2013 were also excluded (Box 2).
Box 2.Exclusion Criteria
- Papers not meeting the PCC attribute.
- Articles published in languages other than English.
- Articles published before January 01, 2013.
- Health systems financing strategies for conditions outside maternal and child health care.
3.6. Data Charting
3.6.1. Data Charting Process.
Data were extracted from the selected papers for the review, first by characterizing them and then charting on Microsoft Excel tables developed by the author. The characteristics were based on the PCC, study methodology and key study findings. .A summary of elements included in the data charting are described in Box 3.
Box 3. Elements included in the data Charting.
- Author(s), Year of Publication, Paper source, paper type, Country, area of focus.
- Physical access to MCH care.
- Financial access to MCH care.
- Both physical and financial access to MCH care
- Quality improvement of MCH care
- Both Quality and Financial access to MCH care.
- Analytical Framework
3.3.Data Syntheses .
3.3.1 Analytical Frame work; The framework classified papers on components of financing strategies that were collectively used for coverage of MCH care across countries . There were a range of access and MCH services utilization with some studies focussing on more than one strategy at a time. I grouped the papers using thematic analysis based on their relevance to the study objective. Since the term “access” has a broader scope, I categorized papers describing assess in two separate categories of physical access and financial access for the purpose of simplicity. In general, there were five categories of health financing strategies based on the themes of the included articles. I categorized them as strategies targeting; 1- Physical access to MCH care, 2- Financial access to MCH care, 3-Both physical and financial access to MCH care, 4-Quality of MCH care, 5-Both Quality of care and financial access (figure 2).
file:///C:/Users/DOKI/AppData/Local/Temp/msohtmlclip1/01/clip_image002.png
Figure 2. Analytical frame work used in analysis of included papers, developed by the author.</p
ANALISIS RESIKO KECELAKAAN KERJA PADA PROYEK KONSTRUKSI GEDUNG BERTINGKAT DI KOTA MAKASSAR (STUDY KASUS: VIDA VIEW APARTEMENT)
No full textABSTRAK :Besarnya angka kecelakaan kerja pada sektor konstruksi menuntut perusahaan-perusahaan yang bergerak dibidang konstruksi untuk mengadakan regulasi untuk menekan angka kecelakaan tersebut.Pada penelitian ini penulis mencoba untuk mengidentifikasi,memberikan penilaian dan memberi penanganan risiko pada kecelakaan kerja yang merupakan upaya dalam menganalisis risiko yang terjadi pada suatu pekerjaan konstruksi. Metode yang dilakukan adalah dengan observasi langsung ke lapangan sebagai langkah awal untuk mengetahui variable-variabel apa saja yang akan dimasukkan ke dalam kueisioner yang nantinya akan disebar ke staf/pekerja pada proyek pembangunan Apartemen Vida View Makassar.Nilai dari kueisioner tersebut selanjutnya diolah dengan metode Fine yang menjadi acuan dalam penilaian risiko.Hasil dari pengelolahan data tersebut menunjukkan bahwa kecelakaan kerja dikelompokkan berdasarkan penyebabnya dan variable pekerjaannya yang dimana dari seluruh risiko kecelakaan kerja,hanya satu variabel kecelakaan yang masuk dalam kecelakaan berkategori substansial(memiliki nilai risiko 70-180),sedangkan sisanya masuk dalam kategori moderat(memiliki nilai risiko 20-70) dan kategori dapat diterima (<20). Setelah dilakukan penanganan risiko,hanya satu variable kecelakaan yang masuk dalam kecelakaan berkategori moderat (memiliki nilai resiko 20-70)sedangkan sisanya masuk dalam kategori Dapat Diterima(memiliki nilai risiko < 20). Kata kunci : Kecelakaan kerja,Analisis Risiko,Metode Fine,Nilai Risiko\ud
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ABSTRACT: The amount of number of accidents in the construction sector requires companies engaged in construction to hold a regulation to reduce the number of the accidents. In this study the author tries to identify, provide an assessment and give risk management in workplace accidents is an effort to analyze the risks occur on a construction job. The method is by direct observation to the field as a first step to determine what variables that will be incorporated into questionnair which will be distributed to staff / workers on development projects Vida View Makassar Apartment. The value of questionnair are then processed by the method Fine which is used in the assessment of risk management . These research indicate that workplace accidents are grouped by cause and variable job where all the risks of occupational accidents, only one variable accidents included in the category of accidents substantially (value risk 70-180), while the rest went into the moderate category (value risk 20-70) and acceptable categories (<20). After treatment the risk, only one variable is entered in the accident accident moderate category (value risk 20-70) while the rest fall into the category of Acceptable (value risk <20). Keywords: Accidents, Risk Analysis, Fine Method, Value Ris
Genomic co-amplification of TPX2 and AURKA with MYC cooperatively promote MYC-driven carcinogenesis
No full textThe AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC
No full textWe identified TPX2 and AURAKA as novel co-regulators on the MYC pathway and proposed a new model of MYC-driven cancer. Co-amplification between 8q24 and 20q leads to co-overexpression of MYC and AURKA/TPX2, which cooperatively induce MYC downstream target genes. Based on this model, inhibiting the AURKA/TPX2 axis would be a novel synthetic lethal therapeutic approach for MYC-driven cancers.
Background
The MYC oncogene has long been established as a central driver in many types of human cancers including colorectal cancer. However, the realization of MYC-targeting therapies remains elusive; as a result, synthetic lethal therapeutic approaches are alternatively being explored. A synthetic lethal therapeutic approach aims to kill MYC-driven tumors by targeting a certain co-regulator on the MYC pathway.
Patients and methods
We analyzed copy number and expression profiles from 130 colorectal cancer tumors together with publicly available datasets to identify co-regulators on the MYC pathway. Candidates were functionally tested by in vitro assays using colorectal cancer and normal fibroblast cell lines. Additionally, survival analyses were carried out on another 159 colorectal cancer patients and public datasets.
Results
Our in silico screening identified two MYC co-regulator candidates, AURKA and TPX2, which are interacting mitotic regulators located on chromosome 20q. We found the two candidates showed frequent co-amplification with the MYC locus while expression levels of MYC and the two genes were positively correlated with those of MYC downstream target genes across multiple cancer types. In vitro, the aberrant expression of MYC AURKA and TPX2 resulted in more aggressive anchorage-independent growth in normal fibroblast cells. Furthermore, knockdown of AURKA or TPX2, or treatment with an AURKA-specific inhibitor effectively suppressed the proliferation of MYC-expressing colorectal cancer cells. Additionally, combined high expression of MYC AURKA and TPX2 proved to be a poor prognostic indicator of colorectal cancer patient survival.
Conclusions
Through bioinformatic analyses and experiments, we proposed TPX2 and AURKA as novel co-regulators on the MYC pathway. Inhibiting the AURKA/TPX2 axis would be a novel synthetic lethal therapeutic approach for MYC-driven cancers.CRESTJapan Science and Technology AgencyNext Generation World-Leading ResearchersJapan Society for the Promotion of ScienceGrant-in-Aid for Scientific ResearchGrants-in-Aid for Scientific Research on Innovative Areas of MEXT ‘Systems Cancer Research’MEXT Strategic Programs on Innovative Research ‘Supercomputational Life Science’Osaka Cancer Societ
Wybrane krajowe i unijne instrumenty prawne jako stymulatory mikroprzedsiębiorczości i konieczny interwencjonizm w okresie pandemii COVID-19
No full textRozważania zawarte w niniejszym artykule powstały w okresie wzmożonej aktywności ustawodawczej zarówno rządów poszczególnych państw, jak i organizacji międzynarodowych w czasie pandemii COVID-19. Celem artykułu jest charakterystyka i próba analizy wybranych instrumentów prawnych w dobie kryzysu gospodarczego oraz uzasadnienie przyjętej tezy o potrzebie działań ukierunkowanych na pobudzenie gospodarcze, szczególnie w sektorze mikroprzedsiębiorców. Metody wykorzystane w artykule stanowią kombinację podstawowych metod badawczych, zgodnie z zasadą pluralizmu metodologicznego, zastosowane zostały metody formalno-dogmatyczna, przez którą autor rozumie wykładnię systemową, językową i funkcjonalną oraz metoda prawno-porównawcza. Metoda formalno-dogmatyczna jest dominująca w zakresie omówienia powstałych regulacji, zaś metoda prawno-porównawcza pozwala dostrzec różnice pomiędzy przyjętymi rozwiązaniami. Wyniki analizy, dane gospodarcze oraz wnioski płynące z podjętych rozważań pozwalają potwierdzić tezę o potrzebie i skuteczności wdrażanych odgórnie instrumentów prawnych w przypadku większości gałęzi gospodarki.
ABSTRACT
The considerations contained in this article were created during the period of increased legislative activity of both governments of individual countries and international organizations during the COVID-19 pandemic. The aim of the article is to describe and attempt to analyze selected legal instruments in the time of economic crisis and to justify the adopted thesis about the need for measures aimed at economic stimulation. The methods used in the article are a combination of basic research methods in accordance with the principle of methodological pluralism, formal and dogmatic methods have been used, by which the author understands a systemic, linguistic and functional interpretation, as well as a legal-comparative method. The formal-dogmatic method is dominant in the discussion of the resulting regulations, and the legal-comparative method allows to notice the differences between the adopted solutions. The results of the analysis, economic data and conclusions drawn from the considerations allow to confirm the thesis about the need and effectiveness of top-down legal instruments implemented in most sectors of the economy
Accurate Inverter Error Compensation and Related Self-Commissioning Scheme in Sensorless Induction Motor Drives
No full textThis paper presents a technique for accurately identifying and compensating the inverter nonlinear voltage errors that deteriorate the performance of sensorless field-oriented controlled drives at low speed. The inverter model is more accurate than the standard signum-based models that are common in the literature, and the self-identification method is based on the feedback signal of the closed-loop flux observer in dc current steady-state conditions. The inverter model can be identified directly by the digital controller at the drive startup with no extra measures other than the motor phase currents and dc-link voltage. After the commissioning session, the compensation does not require to be tuned furthermore and is robust against temperature detuning. The experimental results, presented here for a rotor-flux-oriented SFOC IM drive for home appliances, demonstrate the feasibility of the proposed solution
