6,321 research outputs found
Synthesis and characterization of the first doubly-bridging pyridine-2-thionate (pys) molybdenum complex: crystal structure of [Mo(eta(3)-C3H5)(CO)(2)](2)(eta(1):eta(2): mu-pyS)(2)
No full textA multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme
No full textBackground: Low muscle mass and function have been associated with poorer indicators of physical capability in olderpeople, which are in-turn associated with increased mortality rates. The growth hormone/insulin-like growth factor (GH/IGF)axis is involved in muscle function and genetic variants in genes in the axis may influence measures of physical capability.Methods: As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women from seven UKcohorts aged between 52 and 90 years old were genotyped for six polymorphisms: rs35767 (IGF1), rs7127900 (IGF2),rs2854744 (IGFBP3), rs2943641 (IRS1), rs2665802 (GH1) and the exon-3 deletion of GHR. The polymorphisms have previouslybeen robustly associated with age-related traits or are potentially functional. Meta-analysis was used to pool within-studygenotypic effects of the associations between the polymorphisms and four measures of physical capability: grip strength,timed walk or get up and go, chair rises and standing balance.Results: Few important associations were observed among the several tests. We found evidence that rs2665802 in GH1 wasassociated with inability to balance for 5 s (pooled odds ratio per minor allele = 0.90, 95% CI: 0.82–0.98, p-value = 0.01,n = 10,748), after adjusting for age and sex. We found no evidence for other associations between the polymorphisms andphysical capability traits.Conclusion: Our findings do not provide evidence for a substantial influence of these common polymorphisms in the GH/IGF axis on objectively measured physical capability levels in older adults
Sulfur-assisted chloride and triphenylphosphine dissociation of palladium(II) complex [Pd(PPh3)(2)(eta(1)-SCNMe2)(Cl)]. X-ray structures of [Pd(PPh3)(2)(eta(1)-SCNMe2)(Cl)], [Pd(PPh3)(Cl)](2) (mu, eta(2)-SCNMe2)(2), and [Pd(PPh3)(2)(eta(2)-
No full textNovel palladium and platinum carbene-complexes containing dithiocarbonate ligand [M(PPh3){eta(2)(S,S)-S2CO]{C(SR)(NMe2)}] formed via alkyl migration of O-alkyldithiocarbonate to thiocarbamoyl ligand
No full textHydrothermal synthesis and structural characterization of two pH-controlled Cd-squarate coordination frameworks [Cd-2(C4O4)(2.5)(H2O)(4)]center dot(dpaH)center dot 1.5(H2O) and [Cd(C4O4)(dpa)(OH2)] (dpa=2,2 ’-dipyridylamine)
No full textSynthesis, reactivity, and crystal structure of the eta(2)-thiocarbamoyl palladium complex [Pd(PPh3)(2)(eta(2)-SCNMe2)][PF6]
No full textIdentification of icp11, the most highly expressed gene of shirmp white spot syndrme virus
No full textThe GH-IGF-1 Axis in Circadian Rhythm
No full textOrganisms have developed common behavioral and physiological adaptations to the influence of the day/night cycle. The CLOCK system forms an internal circadian rhythm in the suprachiasmatic nucleus (SCN) during light/dark input. The SCN may synchronize the growth hormone (GH) secretion rhythm with the dimming cycle through somatostatin neurons, and the change of the clock system may be related to the pulsatile release of GH. The GH—insulin-like growth factor 1 (IGF-1) axis and clock system may interact further on the metabolism through regulatory pathways in peripheral organs. We have summarized the current clinical and animal evidence on the interaction of clock systems with the GH—IGF-1 axis and discussed their effects on metabolism
HCMV spread and cell tropism are determined by distinct virus populations.
No full textHuman cytomegalovirus (HCMV) can infect many different cell types in vivo. Two gH/gL complexes are used for entry into cells. gH/gL/pUL(128,130,131A) shows no selectivity for its host cell, whereas formation of a gH/gL/gO complex only restricts the tropism mainly to fibroblasts. Here, we describe that depending on the cell type in which virus replication takes place, virus carrying the gH/gL/pUL(128,130,131A) complex is either released or retained cell-associated. We observed that virus spread in fibroblast cultures was predominantly supernatant-driven, whereas spread in endothelial cell (EC) cultures was predominantly focal. This was due to properties of virus released from fibroblasts and EC. Fibroblasts released virus which could infect both fibroblasts and EC. In contrast, EC released virus which readily infected fibroblasts, but was barely able to infect EC. The EC infection capacities of virus released from fibroblasts or EC correlated with respectively high or low amounts of gH/gL/pUL(128,130,131A) in virus particles. Moreover, we found that focal spread in EC cultures could be attributed to EC-tropic virus tightly associated with EC and not released into the supernatant. Preincubation of fibroblast-derived virus progeny with EC or beads coated with pUL131A-specific antibodies depleted the fraction that could infect EC, and left a fraction that could predominantly infect fibroblasts. These data strongly suggest that HCMV progeny is composed of distinct virus populations. EC specifically retain the EC-tropic population, whereas fibroblasts release EC-tropic and non EC-tropic virus. Our findings offer completely new views on how HCMV spread may be controlled by its host cells
One-, two- and three-dimensional Cu(II) complexes built via new oligopyrazinediamine ligands: from antiferromagnetic to ferromagnetic coupling
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