9,001 research outputs found
Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer
No full textBo-Yong Wang, Quan-Yan Liu, Jun Cao, Ji-Wei Chen, Zhi-Su Liu Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China Abstract: Cyclin-dependent kinase (CDK) family members have been considered as attractive therapeutic targets for cancer. In this study, we aim to investigate the anticancer effects of a selective CDK7 inhibitor, BS-181, in gastric cancer (GC) cell line. Human GC cells (BGC823) were cultured with or without BS-181 at different concentrations for 24–72 hours. BS-181 significantly reduced the activity of CDK7 with downregulation of cyclin D1 and XIAP in GC cells. Treatment with BS-181 induced cell cycle arrest and apoptosis. The expression of Bax and caspase-3 was significantly increased, while Bcl-2 expression was decreased in cells treated with BS-181. In addition, the inhibition of CDK7 with BS-181 resulted in reduced rates of proliferation, migration, and invasion of gastric cells. Those results demonstrated the anticancer activities of selective CDK7 inhibitor BS-181 in BGC823 cells, suggesting that CDK7 may serve as a novel therapeutic target or the treatment of GC. Keywords: selective CDK7 inhibitor, gastric cancer, BS-181, anticancer activitie
Correlation Study between Laboratory Performance and Internship Grades of BS Information Technology and BS Computer Science Students in Lemery Colleges S.Y. 2021-2022
No full textAbstract: The computer lab is very important to the student’s education. Every institution or university should have this as a key resource, especially for tech-related programs like BS Information Technology and BS Computer Science. The purpose of the study is to evaluate the connection between students with BSs in information technology and computer science's laboratory performance and internship grades. The main goal of the study is whether a student's success in the lab during their first year of college has an impact on how well they do in their practicum or internship. The descriptive-correlational study approach was used to demonstrate the laboratory performance of the SY 2021–2022 BSIT and BSCS graduating class. Performance indicators (PI) and the marks they got from the firms during their internships were used to demonstrate this performance. 35 graduates of the BS in information technology and 16 graduates of the BS in computer science from the academic year 2021–2022 are taking part in this study. It was concluded that there is a strong correlation between laboratory performance and academic internships under corporate supervision. These results contribute to a better significance of performance indicator assessment in laboratory procedures. The second goal is to raise the standards of the quality indicators used to evaluate and track students' computer lab performance. The research recommended integrating academic success and student output at work to create more meaningful data for quality improvement.
Keywords: Practicum, Correlation, Computer Laboratory, Performance Indicators.
Title: Correlation Study between Laboratory Performance and Internship Grades of BS Information Technology and BS Computer Science Students in Lemery Colleges S.Y. 2021-2022
Author: Rindel L. Noche, Lovelita D. De Ramos
International Journal of Computer Science and Information Technology Research
ISSN 2348-1196 (print), ISSN 2348-120X (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 39-41
Research Publish Journals
Website: www.researchpublish.com
Published Date: 10-February-2023
DOI: https://doi.org/10.5281/zenodo.7628761
Paper Download Link (Source)
https://www.researchpublish.com/papers/correlation-study-between-laboratory-performance-and-internship-grades-of-bs-information-technology-and-bs-computer-science-students-in-lemery-colleges-sy-2021-2022International Journal of Computer Science and Information Technology Research, ISSN 2348-1196 (print), ISSN 2348-120X (online), Research Publish Journals, Website: www.researchpublish.co
Measurement of B (Bs →dsX) with Bs semileptonic tagging
No full textWe report the first direct measurement of the inclusive branching fraction B(Bs→DsX) via Bs tagging in e+e-→ (5S) events. Tagging is accomplished through a partial reconstruction of semileptonic decays Bs→DsXℓν, where X denotes unreconstructed additional hadrons or photons and ℓ is an electron or muon. With 121.4 fb-1 of data collected at the (5S) resonance by the Belle detector at the KEKB asymmetric-energy e+e- collider, we obtain B(Bs→DsX)=(60.2±5.8±2.3)%, where the first uncertainty is statistical and the second is systematic
Measurement of B (Bs →dsX) with Bs semileptonic tagging
No full textWe report the first direct measurement of the inclusive branching fraction B(Bs→DsX) via Bs tagging in e+e-→ (5S) events. Tagging is accomplished through a partial reconstruction of semileptonic decays Bs→DsXℓν, where X denotes unreconstructed additional hadrons or photons and ℓ is an electron or muon. With 121.4 fb-1 of data collected at the (5S) resonance by the Belle detector at the KEKB asymmetric-energy e+e- collider, we obtain B(Bs→DsX)=(60.2±5.8±2.3)%, where the first uncertainty is statistical and the second is systematic. © 2022 authors. Published by the American Physical Society
Measurement of B (Bs →dsX) with Bs semileptonic tagging
No full textWe report the first direct measurement of the inclusive branching fraction B(Bs→DsX) via Bs tagging in e+e-→ (5S) events. Tagging is accomplished through a partial reconstruction of semileptonic decays Bs→DsXlν, where X denotes unreconstructed additional hadrons or photons and l is an electron or muon. With 121.4 fb-1 of data collected at the (5S) resonance by the Belle detector at the KEKB asymmetric-energy e+e- collider, we obtain B(Bs→DsX)=(60.2±5.8±2.3)%, where the first uncertainty is statistical and the second is systematic
Molecular dynamics simulation for heat transport in thin diamond nanowires
No full textIt is found that the thermal conductivity in narrower DNW is lower and does not show obvious temperature dependence; a very small value (about 2.0 W/m/K) of thermal conductivity is observed in ultra-narrow DNW, which may be of potential applications in thermoelectric devices. These two phenomena are probably due to the dominant surface effect and phonon confinement effect in narrow DNW. Our simulation reveals a high anisotropy in the heat transport of DNW. Specifically, the thermal conductivity in DNW along [110] growth direction is about five times larger than that of [100] and [111] growth directions. The anisotropy is believed to root in the anisotropic group velocity for acoustic phonon modes in DNW along three different growth directions
ABINITIO PSEUDOPOTENTIAL CALCULATIONS OF OPTICAL-PHONON DEFORMATION POTENTIALS IN ZINCBLENDE SEMICONDUCTORS
No full text- …
