1,721,075 research outputs found
Hydrogen peroxide degradable conjugated polymer nanoparticles for fluorescence and photoacoustic bimodal imaging
No full text10.1039/c7cc09856aCHEMICAL COMMUNICATIONS54202518-252
NIR‐II Light Activated Photosensitizer with Aggregation‐Induced Emission for Precise and Efficient Two‐Photon Photodynamic Cancer Cell Ablation
No full text10.1002/adfm.202002546ADVANCED FUNCTIONAL MATERIAL
NIR‐II Excitable Conjugated Polymer Dots with Bright NIR‐I Emission for Deep In Vivo Two‐Photon Brain Imaging Through Intact Skull
No full text10.1002/adfm.201808365ADVANCED FUNCTIONAL MATERIALS291
NIR‐II‐Excited Intravital Two‐Photon Microscopy Distinguishes Deep Cerebral and Tumor Vasculatures with an Ultrabright NIR‐I AIE Luminogen
No full text10.1002/adma.201904447ADVANCED MATERIALS314
Bright AIEgen–Protein Hybrid Nanocomposite for Deep and High‐Resolution In Vivo Two‐Photon Brain Imaging
No full text10.1002/adfm.201902717ADVANCED FUNCTIONAL MATERIALS292
Beyond statistical estimation: differentially private individual computation via shuffling
No full textIn data-driven applications, preserving user privacy while enabling valuable computations remains a critical challenge. Technologies like differential privacy have been pivotal in addressing these concerns. The shuffle model of DP requires no trusted curators and can achieve high utility by leveraging the privacy amplification effect yielded from shuffling. These benefits have led to significant interest in the shuffle model. However, the computation tasks in the shuffle model are limited to statistical estimation, making it inapplicable to real-world scenarios in which each user requires a personalized output. This paper introduces a novel paradigm termed Private Individual Computation (PIC), expanding the shuffle model to support a broader range of permutation-equivariant computations. PIC enables personalized outputs while preserving privacy, and enjoys privacy amplification through shuffling. We propose a concrete protocol that realizes PIC. By using one-time public keys, our protocol enables users to receive their outputs without compromising anonymity, which is essential for privacy amplification. Additionally, we present an optimal randomizer, the Minkowski Response, designed for the PIC model to enhance utility. We formally prove the security and privacy properties of the PIC protocol. Theoretical analysis and empirical evaluations demonstrate PIC’s capability in handling non-statistical computation tasks, and the efficacy of PIC and the Minkowski randomizer in achieving superior utility compared to existing solutions
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy
No full textTwo-photon excited
photodynamic therapy (2PE-PDT) has attracted
great attention in recent years due to its great potential for deep-tissue
and highly spatiotemporally precise cancer therapy. Photosensitizers
(PSs) with high singlet oxygen (1O2) generation
efficiency and large two-photon absorption (2PA) cross-sections are
highly desirable, but the availability of such PSs is limited by challenges
in molecular design. In this work, we report that the polymerization
of small-molecule PSs with aggregation-induced emission (AIE) could
yield conjugated polymer PSs with good brightness, high 1O2 generation efficiency, and large 2PA cross-sections.
A pair of conjugated polymer PSs were designed and synthesized, and
the corresponding AIE PS dots were prepared by nanoprecipitation,
which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver
tumor treatment. Our work highlights a strategy to design highly efficient
PSs for 2PE-PDT
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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