23,420 research outputs found
Wang-Sen
No full text“Wang-Sen” merupakan karya komposisi karawitan yang bertujuan menciptakan komposisi karawitan bentuk baru dengan menggunakan lirik lagu wangsalan dan isen-isen. Ide penciptaannya mengangkat tentang konsep kehidupan sifat dan karakteristik manusia. Konsep tersebut diolah secara musikal dengan menganalogikan sifat-sifat manusia yang digabungan dengan wangsalan dan isen-isen. Judul “Wang-Sen” merupakan sebuah akronim atau penggabungan dua suku kata yaitu dari kata wangsalan dan isen-isen. Wangsalan adalah cakepan atau syair yang digunakan dalam sindenan. Sedangkan isen-isen berarti isi atau isian, yang berfungsi untuk mengisi diantara sindenan srambahan. Komposisi ini terdiri dari empat bagian (kecuali bagian introduksi dan penutup) lagu utama yang merupakan analogi dari kepribadian atau sifat-sifat manusia. Bagian pertama merupakan penggambaran sifat sanguinis (sifat lugu, polos, antusias, ekspresif dan kreatif). Bagian kedua berisi penggambaran sifat melankolis (sifat serius, tekun, berbakat, kreatif, musikal, menghargai keindahan, dan perasa). Bagian lagu ketiga merupakan penggambaran sifat koleris (sifat pemimpin, dinamis, tegas, dan aktif). Bagian empat berisi penggambaran sifat phlegmatis (sifat rendah hati, tidak mudah marah, tenang, dan sabar)
Sen-Lab-LMS/Senescence_nuclear_features: Publication_version_2.0
No full text<p>Author checklist.</p>
Perspectives on Identity, Migration, and Displacement
Get PDFPerspectives on Identity, Migration, and Displacement -- edited by Steven Tötösy de Zepetnek, I-Chun Wang, and Hsiao-Yu Sun (Kaohsiung: National Sun Yat-sen University Press, 2010. ISBN 9789860235418 209 pages, bibliography, index) is a collection of articles about sociological and literary aspects of identity formation as a consequence of (im)migration. (Im)migration results in the problematics of assimilation and hybridity and in postcolonial scholarship, in particular, attention is paid to the concept of migration termed Creolization on the ground that cultural contact, cultural transmission, and cultural transformation result in the creation of new cultures. Copyright release by National Sun Yat-sen University to the authors 2013
The Contributions of Professor Amartya Sen in the Field of Human Rights
Get PDFThis paper analyses the work of the Nobel Prize winning economist Professor Amartya Sen from the perspective of human rights. It assesses the ways in which Sen's research agenda has deepened and expanded human rights discourse in the disciplines of ethics and economics, and examines how his work has promoted cross-fertilisation and integration on this subject across traditional disciplinary divides. The paper suggests that Sen's development of a 'scholarly bridge' between human rights and economics is an important and innovative contribution that has methodological as well as substantive importance and that provides a prototype and stimuli for future research. It also establishes that the idea of fundamental freedoms and human rights is itself an important gateway into understanding the nature, scope and significance of Sen's research. The paper concludes with a brief assessment of the challenges to be addressed in taking Sen's contributions in the field of human rights forward.Amartya Sen, human rights, poverty, freedom, obligation, capability approach, meta-rights, entitlements, opportunity freedom, liberty-rights
Inequalities, Agency, and Well-being: Conceptual Linkages and Measurement Challenges in Development
Get PDFdevelopment, inequality, gender, well-being, agency, capability, distribution, Sen
Abstract 3936: Bromodomain testis-specific protein BRDT is expressed in a subset of esophageal squamous cell carcinomas and controls expression of differentiation-associated genes
No full textAbstract Esophageal cancer is one of the most malignant cancers, ranking as the sixth leading cause of cancer-related deaths worldwide. The poor survival rate and prognosis highlight the limitations in the biological understanding of esophageal cancer and the urgent need for identification of novel targeted molecular therapies. Recently, large scale genomic analyses have revealed the extensive alternations of epigenetic regulators which may be used as a basis for developing new “epigenetic drugs “. BRDT, bromodomain testis-specific protein, is a member of the bromodomain and extra-terminal (BET) family of epigenetic reader proteins. BET proteins can regulate gene expression by recognizing acetylated lysines, thus playing important roles in both normal development and disease progression. Inhibition of BET proteins has emerged as a potential therapy for many types of cancer. In normal human tissues, unlike the other members of BET family, BRDT is exclusively highly expressed in testes where it drives the meiotic and post-meiotic gene expression to promote spermatogenesis. We have identified BRDT to be expressed in over 20% of esophageal squamous cell carcinoma (ESCC), a predominant subtype of esophageal cancer. Knockdown of BRDT does not affect cell proliferation, but leads to alterations in the expression of differentiation markers. In addition, RNA-seq following BRDT knockdown also supports a role of BRDT in cell differentiation. Depletion of BRDT does not alter the cellular response to BET inhibition. Surprisingly, we also identified BRDT transcripts encoding two truncated isoforms lacking the first bromodomain, which could potentially alter its epigenetic reader function. The genome occupancy profile of BRDT showed a significant enrichment at transcription start site (TSS), which is distinct from BRD4. It also showed potential interactions between BRDT and E2F family and SMAD family. Together, we showed that BRDT is overexpressed in ESCC cell lines and may influence ESCC development or progression in a subset of tumors by regulating cell differentiation-associated genes. Citation Format: Xin Wang, Feda H. Hamdan, Madhobi Sen, Ana P. Kutschat, Steven A. Johnsen. Bromodomain testis-specific protein BRDT is expressed in a subset of esophageal squamous cell carcinomas and controls expression of differentiation-associated genes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3936
Abstract 2922: The utility of BET inhibition in the sensitization and re-sensitization of pancreatic cancer cells to paclitaxel
No full textAbstract While the mortality rates of cancer are generally declining, pancreatic cancer persists to be an exception with a 5-year-survival rate of less than 7%. As late diagnosis and resistance to conventional therapies are major contributors to high mortality rates, novel treatment options are needed to improve the prognosis of pancreatic cancer patients. Recent findings showed that inhibition of the Bromodomain and Extraterminal Domain (BET) family of epigenetic reader proteins is effective, both alone and in combination with conventional chemotherapy, in decreasing pancreatic tumor growth in patient-derived xenografts. Thus, we aim to evaluate the potential role of and mechanisms of action of BET inhibitors (BETi) as an adjuvant therapy option in pancreatic ductal adenocarcinoma. We established L3.6 pancreatic cells that are resistant to paclitaxel by maintaining them in incrementally higher concentrations for 3 months. Paclitaxel-resistant cells showed a half maximal inhibitory concentration (IC50) 100-fold higher than that of parental cells. Intriguingly, we report that low, non-cytostatic concentrations of the BETi, JQ1, not only sensitized cells to paclitaxel, but also induced significant re-sensitization of chemoresistant cells. In order to elucidate the mechanism by which BETi induces chemo-sensitization, we investigated the differential gene expression profiles of resistant and sensitive cells. Thereby, we uncovered that BETi reverses the regulation of transcriptionally-activated genes in resistant cells. Interestingly, these genes showed a major tendency to gain BRD4 at putative enhancer regions. We anticipate that enhancer RNAs (eRNAs) transcribed at these particular enhancers may provide us with novel biomarkers which can be used to predict chemotherapeutic resistance and the possibility of re-sensitization by BETi. In conclusion, we provide evidence that BETi can potentially be used as adjuvant agents in pancreatic cancer. However, approaches may likely be largely independent of their anti-proliferative effects that require higher concentrations and possibly lead to intolerable adverse effects, but rather to their transcriptional regulatory functions that attenuate the activated programs in chemoresistant cancers. Citation Format: Feda H. Hamdan, Ana P. Kutschat, Madhobi Sen, Xin Wang, Steven A. Johnsen. The utility of BET inhibition in the sensitization and re-sensitization of pancreatic cancer cells to paclitaxel [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2922
Gift from students of Professor Ming-shen Wang, National Sun Yat-sen University, Taiwan. July 2008
No full textOriginal items are in owners possession. These items are duplicates of original. Photographs: 6 color. Manuscript: typescript, 2 pgs. Printout of email message: 17 pgs. Photograph: 1 color image of typescript letter.The students of Professor Ming-shen Wang of the Institute of Public Affairs Management at the National Sun Yat-sen University in Taiwan presented Warfield with a gift in appreciation for his with Interactive Management (IM). John N. Warfield Digital Collectio
How environmental conditions impact mosquito ecology and Japanese encephalitis: An eco-epidemiological approach
No full textAbstract not availableHuai-Yu Tian, Peng Bi, Bernard Cazelles, Sen Zhou, Shan-Qian Huang, Jing Yang, Yao Pei, Xiao-Xu Wu, Shi-Hong Fu, Shi-Lu Tong, Huan-Yu Wang, Bing X
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