1,720,953 research outputs found
Characterization of the mouse LCN2 receptors in macrophage
No full text摘要
LCN2為疏水性分子結合蛋白家族的其中一員，同時也是一種急性反應蛋白，可藉由受體媒介的胞吞作用進入細胞內部。目前已知有兩種LCN2的受體（receptor）存在於細胞膜，分別為24p3R及megalin。由本實驗室研究結果已知子宮內膜異位炎形成過程中，腹腔液中的LCN2會有明顯增加的趨勢。而施加LCN2抗體則可以使子宮內膜的異位組織縮小，顯示LCN2在生殖系統中具有重要的功能。根據LCN2運送鐵離子的特性，推測當子宮內膜異位炎的形成過程中，腹腔液中高濃度的LCN2可藉巨噬細胞膜上受體使細胞內部鐵離子的濃度產生變化，進一步誘導細胞分泌細胞激素以促進子宮內膜異位炎的生成。因此本研究希望了解LCN2是否藉由受體媒介的胞吞作用造成巨噬細胞鐵離子的濃度的變化。此外，藉由shRNA的實驗分析巨噬細胞上實際參與反應的受體。在研究中利用手術建立小鼠子宮內膜異位症狀的模式，了解LCN2、24p3R及megalin基因在子宮內膜異位發育時的變化，以便推測LCN2與子通內膜異位症形成的關係。綜合所得結果證實LCN2主要是藉由24p3R將鐵離子帶入巨噬細胞中，而這樣的機制也許與子宮內膜異位的形成有關。而另一受體，Megalin，似乎在巨噬細胞對於LCN2的胞吞作用中並無明顯的功能。Abstract
LCN2 belongs to the lipocalin family and performs as an acute phase protein. It can be internalized into the cells via receptor-mediated endocytosis and play a role as an iron transporter. To our knowledge, two LCN2 membrane receptors, 24p3R and megalin, may be in charge of the LCN2 response. According to our previous studies, the level of LCN2 was highly induced in uterus and peritoneal fluid during the development of endometriosis. The administration of LCN2 antibody would diminish the ectopic endometriosis formation. It indicates the significance of LCN2 in reproductive system. LCN2, as an iron-transporter，may activate the macrophage in peritoneal cavity and trigger the secretion of cytokines from macrophage during the endometriosis formation via iron-internalization by LCN2. Currently，we attempt to confirm whether the macrophage can internalize the iron via LCN2 receptor-mediated endocytosis. Furthermore, using shRNA analysis, we identified the real receptor of LCN2 endocytosis in macrophage. The results showed that the iron could be transported the iron into the cell via LCN2-initicated endocytosis, and suggesting the 24p3R is an essential mediator. After establishing a mouse endometriosis model, we examined the gene expressions of LCN2、24p3R and megalin in the possibilities of endometriosis development. The results demonstrated that LCN2 internalized into the macrophage via 24p3R and might be associated with the formation of endometriosis. Megalin seemed to do nothing with LCN2 in macrophage endocytosis and endometriosis formation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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