754 research outputs found
The Evolution of the Virtue from Pre-ch'in Books to Shishuo Xinyu
No full textThis article discussed the meaning of the word \ue2Virtue\ue2 from three ways. First, the author focused on the meaning of word \ue2Virtue\ue2 in Pre-ch'in Books. The historic literatures used are including the Zuozhua,Guo Yu,Zhou Li,Shijing,The Lu-Shi Chun-Qiu,Yanzi Chun Qiu, and Mozi. Secondly, I concern the phenomenon of \ue2the virtue " in the Luenyu, which refers only \ue2Confucius' Four Branches", and analyze the case in the Luenyu for virtue branch four persons\ue2 virtue. Finally, is concerning about the titles in \ue2Shishuo Xinyu\ue2 which are pay tribute to the Luenyu and discussing the title of \ue2Virtue\ue2 is conform to the first and second point. From the Pre-ch'in Books to explore the issue of \ue2the virtue ", and focus on the virtue in" Luenyu " and " Shishuo Xinyu "to clarify the evolution of virtue from the Pre-ch'in Books to Shishuo Xinyu
sj-docx-1-imj-10.1177_10815589231151232 – Supplemental material for Comparison of clinicopathological characteristics and response to neoadjuvant systemic therapy in patients with HER2-low-positive and HER2-zero breast cancer
No full textSupplemental material, sj-docx-1-imj-10.1177_10815589231151232 for Comparison of clinicopathological characteristics and response to neoadjuvant systemic therapy in patients with HER2-low-positive and HER2-zero breast cancer by Wenjie Shi, Xinyu Wan, Jinzhi He, Ye Wang, Weiwei Zhang, Yinggang Xu, Xiaofeng Huang, Rui Chen, Lu Xu, Xiaoming Zha and Jue Wang in Journal of Investigative Medicine</p
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway
Get PDFChangheng Song,1,2,* Qiqi Yan,1,* Yujie Ma,3 Pei Li,1 Ying Yang,1 Yuhan Wang,1 Wenjie Li,1 Xinyu Wan,1 Yubo Li,1 Ruyuan Zhu,1 Haixia Liu,1 Zhiguo Zhang1 1Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 3Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haixia Liu; Zhiguo Zhang, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, No. 16, DongzhimenNei Nanxiaojie Street, Dongcheng District, Beijing, 100700, People’s Republic of China, Email [email protected]; [email protected]: Modified Zuo Gui Wan (MZGW) was a combination of Zuo Gui Wan and red yeast rice used for treating osteoporosis (OP), but its mechanism remains unclear. We aimed to validate the anti-OP effect of MZGW and explore its underlying mechanism.Methods: An ovariectomy (OVX) rat model in vivo and a RANKL-induced osteoclasts (OCs) model in vitro were established. Key active ingredients in MZGW high dose (MZGW-H) group were detected by UPLC-MS/MS. Micro-CT scans and histomorphology analysis were performed in OVX rats. 16S rRNA gene sequencing was performed to investigate the relationship between the anti-OP effect of MZGW-H and intestinal flora. CCK-8 assay was applied to examine the optimal concentration of Modified Zuo Gui Wan drug serum (MZGW-DS) on osteoclasts. The qRT-PCR and Western blotting were utilized to explore the potential anti-OP pathway of MZGW, namely the SCFA-GPR41-p38MAPK signaling pathway. GPR41 was knocked down to further reverse to verify whether the pathway was the key pathway for MZGW-DS to exert its inhibitory effect on osteoclasts.Results: The three main blood components, Ferulic acid, L-Ascorbic acid and Riboflavin, were examined mainly by UPLC-MS/MS. 16S rRNA gene sequencing showed that MZGW-H changed the metabolism of SCFAs. In vivo studies verified that MZGW-H ameliorated microstructure damage, improved histological changes and reduced TRAP, BALP, and BGP in OVX rats by regulating the SCFA-GPR41-p38MAPK signaling pathway. CCK-8 revealed that 5% MZGW-DS group was the most optimal concentration of MZGW-DS to inhibit osteoclast differentiation. In vitro, MZGW-DS was better than peripheral blood concentration of SCFAs in inhibiting osteoclasts. After the knockout of GPR41, MZGW-DS could not inhibit the expression of osteoclast-related protein (CTSK and NFATc1) via SCFA-GPR41-p38MAPK signaling pathway.Conclusion: MZGW-H effectively ameliorates OVX-induced osteoporosis partially achieved by increasing SCFAs metabolism and modulating the SCFA-GPR41-p38MAPK signaling pathway. Keywords: osteoporosis, short chain fatty acids, SCFA-GPR41-p38MAPK signaling pathway, osteoclasts, modified Zuo Gui Wa
Physiological and Metabolic Changes in ‘Xinyu Mandarin’ Following Natural Tetraploidization
No full textThe mandarin is an important fruit crop worldwide, and ‘Xinyu mandarin’—a local Citrus reticulata variety—is widely cultivated in Jiangxi Province, in China. Autopolyploidy has frequently been used for the improvement of crop varieties. In a previous study, we identified a tetraploid (4X) material of ‘Xinyu mandarin’ generated from its diploid (2X) mother seedling via a spontaneous mutation. However, the physiological and metabolic variations after polyploidy are not clear enough, which is not conducive to the early screening. In the present study, we analyzed the morphological, physiological, and metabolic differences between the tetraploid and diploid plants. The tetraploids had larger and thicker leaves, and the activities of key enzymes in photosynthesis, the total chlorophyll, phenolic, and proline contents, were all higher in tetraploids. In the non-targeted metabolomic profile, a total of 522 metabolites were identified, of which 61 were significantly different between diploids and tetraploids. The differential metabolites included similar proportions of primary and secondary metabolites, and most of these were up-regulated in tetraploids, especially stress-related metabolites such as phenolic acids, flavonoids, alkaloids, and so on, indicating that tetraploids may possess better stress tolerance ability and vigor. Therefore, the tetraploids of ‘Xinyu mandarin’ may serve as an excellent female parent for the improvement of citrus varieties
Preservation of Xinyu Tangerines with an Edible Coating Using <i>Ficus hirta</i> Vahl. Fruits Extract-Incorporated Chitosan
No full textXinyu tangerine is a citrus fruit that has enjoyed great popularity in China for its fewer dregs and abundant nutrients. However, it is considered an easily perishable fruit that is vulnerable to various pathogenic fungal infections, especially by Penicillium italicum, which reduces its storage life and commercial value. Normally, to reduce the losses caused by fungal deterioration of harvested fruit, polysaccharide-based edible coating, containing natural antimicrobial agents (e.g., plant extracts), have been applied. In current study, we evaluated the effects of Ficus hirta Vahl. fruits extract (FFE)⁻incorporated chitosan (CS) edible coating on Xinyu tangerines during cold storage at 5 °C. The results showed FFE has efficacy as an antifungal against P. italicum in a dose-dependent manner in vivo, with an EC50 value of 12.543 mg·mL−1. It was found that the edible coating of FFE⁻CS exhibited a higher reduction of total soluble solid (TSS), titrable acid (TA), and ascorbic acid (AsA) content by reducing the fruit decay rate, weight loss, respiration rate, and malondialdehyde (MDA) content during cold storage at 5 °C. Moreover, the activities of protective enzyme such as superoxide dismutase (SOD), peroxidase (POD), and phenylalanine ammonia-lyase (PAL), which have been linked with reactive oxygen species (ROS) and the phenylpropanoid pathway, were higher in the FFE⁻CS-coated fruits. On the basis of these study results, the FFE⁻CS edible coating could reduce postharvest loss and enhance the storability of Xinyu tangerines due to the in vivo antifungal activity of FFE
Paenibacillus brasilensis YS-1: A Potential Biocontrol Agent to Retard Xinyu Tangerine Senescence
No full textThe Xinyu tangerine (Citrus reticulata Blanco) is a non-climacteric fruit that is widely cultivated and consumed in China but highly susceptible to fungal infections. Antagonistic microorganisms can control postharvest diseases and extend the storage life of citrus fruits. However, little work has been done to investigate the effects of applying Paenibacillus brasilensis YS-1 by immersion to enhance the cold storability of Xinyu tangerines. Fruits were soaked with P. brasilensis YS-1 fermented filtrates for 10 min and in sterile water as the control. The decay incidence, weight loss, nutrient content, respiration rate, malondialdehyde (MDA) content, and defensive enzymes activities in citrus fruit were measured during cold storage at 5 ± 0.5 °C. The results showed that P. brasilensis YS-1 treatment significantly reduced postharvest decay and effectively maintained the nutritional quality compared to the control under cold storage. The weight loss, respiration rate, and MDA content were lower in P. brasilensis YS-1-treated fruits than the control fruits, indicating that P. brasilensis YS-1 treatment increased the activities of superoxide dismutase (SOD), peroxidase (POD), polyphenol oxidase (PPO), and phenylalnine ammonia-lyase (PAL). According to the results, a postharvest application of P. brasilensis YS-1 can control the postharvest decay and maintain fruit quality, as well as increase the defensive enzyme activity, so as to achieve the purpose of retarding postharvest senescence in citrus fruit
Effect of carboxymethyl cellulose coating enriched with clove oil on postharvest quality of ‘Xinyu’ mandarin oranges
No full textIntroduction. Attempts to exploit natural preservatives to control postharvest diseases as an alternative technology to synthetic fungicides in citrus fruit have been drawing much attention. Materials and methods. The combined effects of carboxymethyl cellulose (CMC) coating and/or clove oil on the qualitative properties of cold-stored ‘Xinyu’ mandarin oranges stored at 5 °C for 120 days were investigated. Results and discussion. The results showed that the addition of clove oil as an antifungal component to the CMC coating had a good effect on the inhibitory growth of fungal decay, and the coating treatments significantly decreased the decay rate and weight loss, as well as the maleic dialdehyde (MDA) concentration compared with control samples. The clove oil-carboxymethyl cellulose (CO-CMC) coating significantly maintained commercial quality and inhibited respiration. Meanwhile, the results showed that the activities of superoxide dismutase (SOD), catalase (CAT), polyphenol oxidase (PPO) and phenylalanine ammonia lyase (PAL) in fruit treated with CO-CMC coating were higher than in those treated with CMC coating and control samples. Conclusion. The CO-CMC coating has good potential for application as an alternative to synthetic fungicides for improving postharvest quality and prolonging the shelf life of ‘Xinyu’ mandarin oranges during cold storage
Residential self-selection in the relationship between the built environment and travel behavior: A literature review and research agenda
No full textThis chapter gives an overview of the current debates on residential self-selection and presents a related research agenda. Here, we define residential self-selection as “the tendency of people to choose residential locations based on their travel abilities, needs and preferences.” Debates relate to theory/causalities (including the role of attitudes), research methods, empirical findings (including the magnitude of the importance of residential self-selection for the influence of the built environment on travel behavior and the dominance of OECD (Organization for Economic Co-operation and Development) countries), and the implications for planning. The main contribution is in translating the current debates into a research agenda. Challenging avenues for future research are partly inspired by these debates, and include changing attitudes, qualitative research, multiple causal structures, extending the scope to other areas than residential areas, the existence of threshold values for the strength of preferences to be important for residential self-selection, the role of perceived accessibility, non-OECD countries, and planning implications.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and Logistic
Indigenization of Fugitives and Cultural Changes: Using Shishuo Xinyu(世説新語) as a Material
Get PDFThe research to date on Shishuo Xinyu 世説新語 compiled by Yiqing, Prince of Linchuan, has relied on the interpretation that it was a work extolling the reign of Liu-Song (Southern Song) Dynasty Emperor Wen (407-553) as the last great achievement of the Han aristocracy and decrying the present decay of the aristocracy through comparisons with the golden ages of the past.On the other hand, a question should be raised as to why all the sequels of Shishuo Xlnyu ending in Liao Dynasty Emperor Yuan’s Jinlouzi 金楼子, compiled by members of generations from whom even the last flourish lay far into the past and thus had no personal experience of what a golden age was really like.In an attempt to reply to such an inquiry, the author of this article points to the necessity of focusing on the historical background of the Sahishuo Xlnyu genre and offers the hypothesis that the compilation of the original work was deeply affected by cultural changes caused by the indigenization of non-Han people fleeing from the northeast (qiaomin 僑民), which also influenced the tone of all its sequels.In more concrete terms, the article begins with the comment that there is no research to date that seriously engages the question of why Shishuo Xinyu contains both positive and negative evaluations of the qingtan 清談 style of intellectual discourse.Secondly, since the main political objective of the Eastern Jin Dynasty’s Jiangnan Regime was the recovery of the Chinese heartland, the decision was made that cultural policy, beginning with state protocol and also including qingtan institutions, should not be given priority.Next, the term shenzhou 神州, which indicated the center of the universe, and during the early Eastern Jin Period was geographically identified with the Chinese heartland, gradually moved to the Yangzhou region centered upon Jiankang 建康, which had become prosperous due in part to the successful indigenization of foreign refugees.This change in universal nucleus required cultural adjustments that brought about such phenomenon as the revival in popularity of qingfan as far as the Liao through reforms in state protocol implemented during the reign of Emperor Wen. Therefore the writing of Shishuo Xinyu reflects the decision to abandon recovery in the Chinese heartland and a period of cultural transformation made possible by that decision.Finally, in the background to the parts of Shishuo Xinyu critical of qingtan from the standpoint of Chinese heartland’s recovery and those not critical, lurks the two views concerning where the center of the universe actually lies.journal articl
Correction to: Novel distance measures on complex picture fuzzy environment: applications in pattern recognition, medical diagnosis and clustering (Journal of Applied Mathematics and Computing, (2025), 71, 2, (1743-1775), 10.1007/s12190-024-02293-z)
No full textTypesetter misread author proof corrections and swapped affiliation of third author Letchmuna to College of Mathematics and Computer, Xinyu University, Xinyu, 338004, China instead of School of Computer Sciences, Universiti Sains Malaysia, Penang, 11800,Malaysia. just as per original submission and needs to be corrected. Original article has been corrected. © 2025 Elsevier B.V., All rights reserved
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