1,720,952 research outputs found
Return to work with chronic pain: employers' and employees' views
Full text linkThis conference papers given to the Society of Occupational Medicine's Annual Scientific Meeting discusses tensions and some possible ameliorating activities from our 2013 paper of the same name., published in their journal: Wainwright, E., Wainwright, D., Keogh, E. and Eccleston, C. Return to work with chronic pain: employers’ and employees’ views. Occupational Medicine 2013: doi:0.1093/occmed/kqt109. The conference homepage is here;http://www.som-asm.org.uk/Programme_SOM_ASM.aspAbstractBackgroundThe sickness certification and return to work (RTW) of people with chronic pain are important health and economic issues for employees, employers, taxpayers and the UK government. The ‘fit note’ and a national educational programme promoting RTW were introduced in 2010 to curb rising rates of sickness absence. AimsTo investigate employers’ and employees’ experiences of managing RTW when someone has taken sick leave for chronic pain, and to explore the perceived efficacy of the fit note.MethodsA qualitative study, comprising semi-structured interviews with employers who had managed sick leave cases and employees who had experienced sick leave for chronic pain. Interviews were recorded, transcribed and the data analysed using constructivist grounded theory principles.ResultsFive themes were elicited. Firstly, frequent enquiry after health status was seen as intrusive by some employees but part of good practice by employers and acknowledging this difference was useful. Secondly, being able to trust employees due to their performance track record was helpful for employers when dealing with complex chronic pain conditions. Thirdly, feeling valued increased employees’ motivation to return to work. Fourthly, guidelines about maintaining contact with absent employees were useful if used flexibly. Finally, both parties valued the fit note for its positive language, interrogative format and biomedical authority. ConclusionsThe fit note was perceived to be helpful if used in combination with other strategies for managing sick leave and RTW for people with chronic pain. These strategies may be applicable to other fluctuating, long-term conditions with medically unexplained elements. <br/
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
Full text linkGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF-A) produced by tumor-associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF-A into tumors at the benign stages. This stimulated formation of a high-density vessel network and in macrophage-depleted mice, was followed by accelerated tumor progression. The expression of VEGF-A led to a massive infiltration into the tumor of leukocytes that were mostly macrophages. This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion
Synthesis and x-ray crystal structure of meso-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-1,8-di- (1-methyl-naphthalene).
No full textThe pendant-arm macrocycle, meso-5,5,7,12,12,14-hexamethy 1,4,8,11-tetraazacyclotetradecane- 1,8-di-(1-methylnaphthalene) has been synthesized and its single crystal structure determined. The molecule crystallizes in a primitive monoclinic cell, with the space group P2(1)/a (#14). The cell dimensions are a = 10.778(3)Angstrom, b = 13.809(3) Angstrom, c = 11.420(2) Angstrom, There Exists = 102.49(2)degrees, volume = 1659.5(6) Angstrom(3).PT: J; CR: *MOL STRUCT CORP, 1997, TEXS WIND VERS 1 05 ALTOMARE A, 1993, J APPL CRYSTALLOGR, V26, P343 BEURSKENS PT, 1994, DIRDIF 94 PROGRAM SY BISSESSUR R, 2001, CHEM COMMUN 0907, P1598 COLLIN JP, 1987, J CHEM SOC CHEM COMM, P1075 COSTAMAGNA J, 2000, COORDIN CHEM REV, V196, P125 COX JPL, 1989, J CHEM SOC CHEM COMM, P797 CURTIS NF, 1964, J CHEM SOC, P2644 DOUGLAS BD, 1978, INORGANIC SYNTHESIS, V18, P10 HAINES RI, 2001, CAN J CHEM, V79, P54 HAINES RI, 2001, J INORG BIOCHEM, V85, P1 HAINES RI, 2001, REV INORG CHEM, V21, P165 HAINES RI, 2002, TRANSIT METAL CHEM, V27, P284 KIMURA E, 1985, J CHEM SOC CHEM COMM, P385 MCAULEY A, 2000, COORDIN CHEM REV, V200, P75 MORPHY JR, 1989, J CHEM SOC CHEM COMM, P792 WAINWRIGHT KP, 1997, COORDIN CHEM REV, V166, P35; NR: 17; TC: 0; J9: MOLECULES; PG: 8; GA: 670NASource type: Electronic(1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
How to weigh coastal hazard against economic consequence (poster)
No full textIt is well recognised that sea level change over the coming century will have an extraordinary economic impact on coastal communities. To overcome the uncertainty that still surrounds the mechanics of shoreline recession and stochastic forcing, landuse planning and management decisions will require a robust and quantitative risk-based approach. A new approach is presented, which has been evaluated using field measurements and assessed in economic terms. The paper discusses a framework for coastal risk analysis which combines four main components 1) the effects of non-stationary climate, including decade scale variability and anthropogenic change; 2) a full probabilistic assessment of incident wave and surge conditions; 3) determination of storm erosion extents; and 4) the economic impact of combined coastal erosion and recession. The framework is illustrated in Figure 1. The operation of this framework has been demonstrated, building upon previous work (Callaghan et al., 2008; Jongejan et al., 2011; Ranasinghe et al., 2011). The first three components relate to physical hazards. Using stochastic simulation, we quantify the ‘likelihood’ side of risk. That likelihood is typically represented by lines indicating a projected extreme landward shoreline condition and an associated quantitative probability. For the first time, the effects of non-stationary climate (e.g. sea level rise) have been included. This can be extended to include decadal scale climate variation effects such as beach rotation. The fourth component requires the determination of values associated with land threatened by coastal erosion during the time frame being considered. We assign a spatially varying value density relationship. The exceedance probability of erosion is combined with the value density to calculate the expected value of damage at a given point in time. In a non-stationary climate scenario, the exceedance probabilities change with time, and this is also considered. Given a known rate of return on investment, the differentials in the rates of return (between coastal and inland property investments) are subsequently used to determine the efficient position of the setback line. The results are presented within a GIS framework to effectively feed into the coastal land use planning process. We demonstrate the framework by applying it to using real data (both physical and economic) for our subject site, Narrabeen Beach in Sydney.Hydraulic EngineeringCivil Engineering and Geoscience
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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