1,721,043 research outputs found
Young Investigator: Wahajuddin
No full text Supervisor’s supporting comments Wahajuddin has shown strong enthusiasm with equal intensity of hard work in bioanalytical research since the day he joined as a scientist in this department. His intrinsic learning abilities made him acquire deep knowledge in the area of bioanalysis and he quickly became competent in conducting regulatory/exploratory studies in pharmacokinetics, biopharmaceutics and drug metabolism – harnessing the strengths of bioanalysis. Due to his skills and knowledge in advanced pharmaceutical analysis tools and techniques, he has also been given the responsibility to work as course coordinator for MS (Pharm.) Pharmaceutics at the newly established National Institute of Pharmaceutical Education and Research, which is an institute of national importance under the aegis of the Ministry of Chemicals and Fertilizers, Government of India. Through our Young Knowledge Promotion Initiative and Young Leadership Promotion Initiative, Wahajuddin was given the responsibility of being the corresponding author and first co-author in the majority of papers that have been published by our group, since he was instrumental in generating ideas, planning and executing the studies, compiling and analyzing the data and in writing and communicating the manuscripts. This enabled him to publish very good work in journals such as the Journal of Chromatography B, the Journal of Separation Science, Food & Chemical Toxicology, the Journal of Nutritional Biochemistry and Menopause within a very short period. Many other manuscripts are at various stages of communication and publication. His contribution also resulted in filing a patent application from the Central Drug Research Institute in 2007 (patent No.: #0081NF2007). He has also presented his work at many international conferences, symposia and seminars. He recently presented his work at the International Pharmaceutical Federation Pharmaceutical Science World Congress 2010 in association with American Association of Pharmaceutical Scientists Annual Exposition 2010 held on 14–18 November 2010 in New Orleans, USA. I am sure that he will achieve even greater feats in times to come and strongly recommend his candidature for Bioanalysis: Young Investigator 2011. Nominated by: Girish Kumar Jain, Deputy Director & Head, Division of Pharmacokinetics & Metabolism, Central Drug Research Institute, CSIR, Lucknow, India. [email protected] </jats:p
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view
No full textP-glycoprotein is an important transporter belonging to ATP-Binding Cassette pumps (ABC-B1). This transporter plays a fundamental role in several degenerative diseases such as Alzheimer's, Parkinson's and other forms of dementia, as well as in tumors. This transporter is localized at the blood brain barrier (BBB) where it is involved in the efflux of endogenous and exogenous compounds and it is overexpressed in several tumor cell lines determining Multi Drug Resistance (MDR). In this chapter, we will examine the in vitro biological assays useful to establish the P-gp interactive mechanisms of a ligand and its potential in terms of therapy and diagnosis. In addition, examples of Structure Activity Relationship (SAR) studies of P-gp modulators will be described. Moreover, P-gp imaging by PET with different radioligands (11C and 18F -radiolabelled) will be herein discussed. Finally, the difficulty in the definition of a pharmacophore for the design of substrates, modulators and inhibitors is also critically approached in this chapter
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
No full textWahajuddin,1,2 Sumit Arora21Pharmacokinetics and Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 2Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Rae Bareli, IndiaAbstract: A targeted drug delivery system is the need of the hour. Guiding magnetic iron oxide nanoparticles with the help of an external magnetic field to its target is the principle behind the development of superparamagnetic iron oxide nanoparticles (SPIONs) as novel drug delivery vehicles. SPIONs are small synthetic &gamma;-Fe2O3 (maghemite) or Fe3O4 (magnetite) particles with a core ranging between 10 nm and 100 nm in diameter. These magnetic particles are coated with certain biocompatible polymers, such as dextran or polyethylene glycol, which provide chemical handles for the conjugation of therapeutic agents and also improve their blood distribution profile. The current research on SPIONs is opening up wide horizons for their use as diagnostic agents in magnetic resonance imaging as well as for drug delivery vehicles. Delivery of anticancer drugs by coupling with functionalized SPIONs to their targeted site is one of the most pursued areas of research in the development of cancer treatment strategies. SPIONs have also demonstrated their efficiency as nonviral gene vectors that facilitate the introduction of plasmids into the nucleus at rates multifold those of routinely available standard technologies. SPION-induced hyperthermia has also been utilized for localized killing of cancerous cells. Despite their potential biomedical application, alteration in gene expression profiles, disturbance in iron homeostasis, oxidative stress, and altered cellular responses are some SPION-related toxicological aspects which require due consideration. This review provides a comprehensive understanding of SPIONs with regard to their method of preparation, their utility as drug delivery vehicles, and some concerns which need to be resolved before they can be moved from bench top to bedside.Keywords: superparamagnetic iron oxide nanoparticles, SPIONs, targeted delivery, coating, functionalization, targeting ligands, toxicit
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