697 research outputs found
Arbitration and Dispute Settlement in Foreign Indirect Investment. The increasing significance and use of arbitration in international loan agreements, syndicated loans and international bond issues
No full textThis dissertation examines the suitability of arbitration for the resolution of securities regulatory claims and it adoption globally, which has resulted in international arbitration becoming the favoured dispute resolution mechanism in the securities industry. The author explains that disputes arising out of international bilateral and syndicated loan agreements are generally considered to be arbitrable, while international bond disputes are often derived from the controversies over the application of mandatory national laws and the compliance with securities regulation provisions - so the arbitrability of international bond disputes depends on the acceptance of the arbitrability of securities regulatory claims
A monolithically integrated power JFET and Junction Barrier Schottky diode in 4H silicon carbide
No full textEfficiency of power management circuits depends significantly on their constituent switches and rectifiers. The demands of technology are increasingly running up against the intrinsic properties of Si based power devices. 4H-Silicon Carbide (SiC) has superior properties that make it attractive for high power applications. SiC rectifiers are already a competitive choice and SiC switches have also been commercialized recently. Junction Barrier Schottky (JBS) diodes, which combine the advantages of PN and Schottky, have higher Figure of Merit (FOM) as rectifiers. Among switches, a robust and mature process has been developed for Silicon Carbide Vertical Junction Field Effect Transistors (VJFETs), which currently gives it the highest unipolar FOM. Switches are frequently combined with anti-parallel diodes in power circuits. This thesis describes the development of a SiC-based monolithically integrated power switch and diode. Monolithic integration increases reliability and efficiency, and reduces cost. Because of their superior properties and similarities in fabrication, we chose the SiC VJFET and JBS diode as the switch and rectifier. Detailed design, fabrication and characterization of the integrated switch to block above 800 V and conduct current beyond 100 A/cm2 is explained. In this process, the first physics-based 2-D compact model is developed for reverse leakage in a JBS diode as a function of design parameters. Since the gate-channel junctions of SiC VJFETs cannot be assumed to be abrupt, an existing analytical model for Si VJFETs is extended to account for graded gate-channel junctions. Using these analytical models, design rules are developed for the VJFET and JBS diode. Finite element simulations are used to find the best anode layout of the JBS diode and optimize electric field termination in the integrated device to ensure their capability to operate at high voltage. Finally, a spin-on glass based process is developed for filling the gate trenches of the VJFET to improve long-term robustness in extreme environments. The integrated power switch developed in this thesis points to the attractions of monolithic integration in SiC power circuits. Analytical compact design equations derived here will facilitate faster and easier design of switches and rectifiers for desired circuit operation.Ph. D.Includes bibliographical referencesIncludes vitaby Rahul Radhakrishna
Synthesis and <i>In Vitro</i> Anti-inflammatory Activity of 5-arylidene-1-[(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones.
No full textSynthesis and <i>In Vitro</i> Anti-inflammatory Activity of Some 1-[(2(Methylsulphonyl amino) thiazole-4-yl) methyl]-3-aryl thioureas.
No full textChiral superconductivity from repulsive interactions in doped graphene
Get PDFAuthor Manuscript 17 Sep 2011Chiral superconductivity, which breaks time-reversal symmetry, can exhibit a wealth of fascinating properties that are highly sought after for nanoscience applications. We identify doped graphene monolayer as a system where chiral superconductivity can be realized. In this material, a unique situation arises at a doping where the Fermi surface is nested and the density of states is singular. In this regime, d-wave superconductivity can emerge from repulsive electron–electron interactions. Using a renormalization group method, we argue that superconductivity dominates over all competing orders for generic weak repulsive interactions. Superconductivity develops simultaneously in two degenerate d-wave pairing channels. We argue that the resulting superconducting state is of chiral type, with the phase of the superconducting order parameter winding by 4π around the Fermi surface. Realization of this state in doped graphene will prove that superconductivity can emerge from electron–electron repulsion, and will open the door to applications of chiral superconductivity
SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial Cancers
No full textSummary: Wnt signaling is involved in the regulation of cancer stem cells (CSCs); however, the molecular mechanism involved is still obscure. SFRP1, a Wnt inhibitor, is downregulated in various human cancers; however, its role in tumor initiation and CSC regulation remains unexplored. Here, we used a skin carcinogenesis model, which showed early tumor initiation in Sfrp1−/− (Sfrp1 knockout) mice and increased tumorigenic potential of Sfrp1−/− CSCs. Expression profiling on Sfrp1−/− CSCs showed upregulation of genes involved in epithelial to mesenchymal transition, stemness, proliferation, and metastasis. Further, SOX-2 and SFRP1 expression was validated in human skin cutaneous squamous cell carcinoma, head and neck squamous cell carcinoma, and breast cancer. The data showed downregulation of SFRP1 and upregulation of SOX-2, establishing their inverse correlation. Importantly, we broadly uncover an inverse correlation of SFRP1 and SOX-2 in epithelial cancers that may be used as a potential prognostic marker in the management of cancer. : Dr. Waghmare and his colleagues showed the importance of Sfrp1 in mouse skin tumor initiation and CSC regulation. Sfrp1 loss enhanced in vivo tumorigenic potential of CSCs with upregulation of EMT and stemness markers. Sfrp1 and Sox-2 showed an inverse correlation in multiple human epithelial cancers with poor overall survival. Therefore, Sfrp1 can be used as a prognostic marker in human epithelial cancers. Keywords: cancer stem cells, CSCs, epithelial to mesenchymal transition, EMT, epithelial cancer, Sfrp1 (secreted frizzled-related protein), tumorigenic potential, skin squamous cell carcinoma, head and neck squamous cell carcinoma, HNSC
Adding diversity and realism to LAVA, a vulnerability addition system
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 63-64).In this thesis, I designed and implemented several modifications to LAVA, a vulnerability addition system, with the goal of improving realism and diversity of the injected bugs. Specifically, I describe three separate improvements: a method to add fake bugs alongside real ones in order to decrease bug discoverability, two approaches to increase the complexity of the data flow of the inserted bugs, and a standalone program that uses equality saturation to diversify C-source codebases that can be added as a final stage to LAVA. Finally, I present two instances of bug-finding competitions-AutoCTF and Rode0day-that I helped design and run, which leveraged LAVA and the augmentations described in this thesis in order to accomplish their respective goals.by Rahul Sridhar.M. Eng
Measures for Cost Escalation in Bridge
Get PDFThe study throws light on various existing and traditional methods that are being used in computation of Cost Escalation in the construction sector. The thesis reviews the existing methods for calculation of escalation in India and premeditates the techniques adopted by the other nations across the globe. The existing method in India uses Wholesale Price Index (WPI) for materials and Consumer Price Index (CPI) for labour to calculate the escalation. Similar approach is being followed by many other countries too, but now-a-days some of the organisations have realized the shortfalls and hitches in this traditional method. Few organisations have taken initiative to develop construction specific cost indices such as Construction cost index (CCI), Producer Price Index (PPI), etc. The cost of escalation obtained from the present method is too low than the actual escalation amount incurred in the projects. The three main reasons for such a difference are: the use of WPI which is a general price index, the non availability of indices for majority of construction materials and the absence of construction specific regional wise cost indexes. Hence an urgent need has been felt to review the present approach. The use of actual prices (purchase rates) of the materials in the escalation formulae and secondly, the adoption of CCI to calculate escalation. In this study both the methods suggested have been proved with valid practical data and evidences and have been found to be significantly better than the existing approach
Knowledge Creation at Incubation for Business Model Innovation: The Conceptual Understanding
No full textAdaptive Intrusion Detection in Edge Computing using Cerebellar Model Articulation Controller and Spline Fit
Get PDFInternet-of-Thing (IoT) faces various security attacks. Different solutions exist to mitigate the intrusion problems. However, the existing solutions lack behind in dealing with heterogeneity of attack sources and features. The future anticipated demand of devices' connections also urge the need of new solutions addressing the concerns of time consumption and complexity. In this article, we show a novel solution for the intrusion detection in IoT framework. We configure the intrusion detection in the edge computing layer so that the effect of the attack is not propagated to the clouds. Our solution uses cerebellar model articulation controller with kernel map. This combination is very new in the direction of intrusion detection; hence, it emphasizes the novelty of our proposed intrusion detection solution. We name our solution as Cerebellar Model Articulation Controller based Intrusion Detection System (CMACIDS). Additionally, we use spline fitting to the kernel mapping for the model fit; this adds on another novel contribution to CMACIDS. The results obtained with our detection system are compared with the state-of-the-art solutions in terms of complexity, false alarms, and precision of detection. The analysis of the comparative study proves the efficiency of the solution and makes CMACIDS suitable for IoT paradigm. </p
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