1,236 research outputs found
Local and Global Models for Articulated Motion Analysis
No full textVision is likely the most important of the senses employed by humans in understanding their environment, but computer systems are still sorely lacking in this respect. The number of potential applications for visually capable computer systems is huge; this thesis focuses on the field of motion capture, in particular dealing with the problems encountered when analysing the motion of articulated or jointed targets, such as people. Joint articulation greatly increases the complexity of a target object, and increases the incidence of self-occlusion (one body part obscuring another). These problems are compounded in typical outdoor scenes by the clutter and noise generated by other objects. This thesis presents a model-based approach to automated extraction of walking people from video data, under indoor and outdoor capture conditions. Local and global modelling strategies are employed in an iterative process, similar to the Generalised Expectation-Maximisation algorithm. Prior knowledge of human shape, gait motion and self-occlusion is used to guide this extraction process. The extracted shape and motion information is applied to construct a gait signature, sufficient for recognition purposes. Results are presented demonstrating the success of this approach on the Southampton Gait Database, comprising 4820 sequences from 115 subjects. A recognition rate of 98.6% is achieved on clean indoor data, comparing favourably with other published approaches. This recognition rate is reduced to 87.1% under the more difficult outdoor capture conditions. Additional analyses are presented examining the discriminative potential of model features. It is shown that the majority of discriminative potential is contained within body shape features and gait frequency, although motion dynamics also make a significant contribution
Evolution of cooperation among tumor cells
No full textThe evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103NIH U56 CA113004; to David E. AxelrodR.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.NIH CA69568; to Kenneth J. PientaNIH CA102872; to Kenneth J. PientaNIH CA093900; to Kenneth J. PientaNSF SES-0240852; to Robert AxelrodNJ Commission on Cancer Research 1076-CCR-SO; to David E. AxelrodAlso available in PubMed Central. PMCID: PMC155738
Latino politics: identity, mobilization, and representation
No full textDue to the dramatic growth of the Latino population in America, in combination with the relative decline of the Anglo (non-Hispanic white) share, Latino Studies is increasingly at the forefront of political concern. With Latino Politics: Identity, Mobilization, and Representation, editors Rodolfo Espino, David L. Leal, and Kenneth J. Meier bring together essays from a number of leading scholars to address the ever-more important issues within the field. Providing an overview of issues surrounding Latino identity and political opinion—such as differences among Latino groups based on national origin, the importance of descriptive representation, and issues of competition and cooperation, particularly with reference to African Americans—the editors speak to the many fundamental debates ingrained in the discipline.
In addition to highlighting important contributions of the study of Latino politics to date, this volume suggests areas that have yet to be explored and, perhaps more importantly, demonstrates how the study of Latino politics relates to broader questions of American politics and society. Foregrounding debates in the overall discipline of political science, the collection will appeal to those who study Latino politics as well as those who are interested in understanding American politics and society with reference to Latino and "minority" concerns
The invisible artist: Arrangers in popular music (1950-2000): Their contribution and techniques
No full textThis thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.This thesis is based on the research conducted by the author for the series,
Richard Niles' History of Pop Arranging, seven thirty-minute documentary
programmes for BBC Radio 2, researched, written and presented by the author and
broadcast in 2003. It also draws on interviews conducted by the author (and other
research) between 2002 and 2007 both for the radio series and for this thesis and on
the author's experience as a professional arranger in popular music working with
many of the genre's significant recording artists including Paul McCartney, Ray
Charles, Cher, Tina Turner, Westlife, Tears For Fears, Dusty Springfield, James
Brown, Pet Shop Boys, Kylie Minogue and producers including Trevor Hom, Steve
Lipson, Steve Mac and Steve Anderson.
It will be argued that the role of the arranger in popular music has often been
undervalued and that during a critical period of popular music history (1950-2000)
arrangers played a significant part in the evolution of musical content. This thesis is,
to the best of the author's knowledge, the first time (apart from the above mentioned
documentary) the subject has ever been examined. The arranger is "invisible" because musical arrangers are often un-credited on
record liner notes or in books or articles concerning popular music. A considerable
amount of research has been necessary to determine who wrote many of the
arrangements considered herein. Motown's Berry Gordy purposely kept the names of
musicians and arrangers off the records because he feared others might 'poach' the
trademark 'Motown Sound'. Other record labels considered the job of the arranger to
be reminiscent of an earlier era, diluting the Rock 'n' Roll image of emotion and
spontanaeity they wished to promote. Some producers and recording artists disliked
sharing credit for their work. Motown arranger David Van dePitte told the author that
arranging was "thankless and anonymous - a very service-oriented profession where
others often take credit for what you've done." Arranging has therefore remained an
intrinsically unseen art created by 'invisible' artists. By analyzing many recordings,
revealing the techniques and concepts they have used in their work to create popular
records, arrangers and their art will be made more 'visible'
Introductory nuclear physics / Kenneth S. Krane.
No full textRev. ed. of: Introductory nuclear physics / David Halliday. 2nd ed. 1955.Includes bibliographies and index.xiii, 845 pages.
Ecological therapy for cancer: Defining tumors utilizing an ecosystem paradigm suggests new opportunities for novel cancer treatments
No full textWe propose that there is an opportunity to devise new cancer therapies based on the recognition that tumors have properties of ecological systems. Traditionally, localized treatment has targeted the cancer cells directly by removing them (surgery) or killing them (chemotherapy and radiation). These modes of therapy have not always been effective because many tumors recur after these therapies, either because not all of the cells are killed (local recurrence) or because the cancer cells had already escaped the primary tumor environment (distant recurrence). There has been an increasing recognition that the tumor microenvironment contains host noncancer cells in addition to cancer cells, interacting in a dynamic fashion over time. The cancer cells compete and/or cooperate with nontumor cells, and the cancer cells may compete and/or cooperate with each other. It has been demonstrated that these interactions can alter the genotype and phenotype of the host cells as well as the cancer cells. The interaction of these cancer and host cells to remodel the normal host organ microenvironment may best be conceptualized as an evolving ecosystem. In classic terms, an ecosystem describes the physical and biological components of an environment in relation to each other as a unit. Here, we review some properties of tumor microenvironments and ecological systems and indicate similarities between them. We propose that describing tumors as ecological systems defines new opportunities for novel cancer therapies and use the development of prostate cancer metastases as an example.We refer to this as “ecological therapy” for cancer
Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome
No full textEpigenetics refers to heritable changes in gene expression that are not attributable to changes in DNA sequence and impacts many areas of applied and basic biology including developmental biology, gene therapy, somatic cell nuclear transfer, somatic cell reprogramming, and stem cell biology. Epigenetic changes are known to contribute to aging in addition to multiple disease states. Epigenetic changes can be influenced by environmental factors that in turn can be inherited by daughter cells during cell division and can also be inherited through the germ line. Thus, it is intriguing to consider that epigenetics, in general, may play a role in human conditions that are strongly influenced by changes in the environment and lifestyle. In particular, metabolic syndrome, a condition increasing in prevalence around the world, is one such condition for which epigenetics is postulated to contribute. Epigenetic defects (epimutations) are thought to be more easily reversible (when compared with genetic defects) and, as such, have inspired efforts to identify novel compounds that correct epimutations or preventprogression to the disease state. These efforts have resulted in the development of a rapidly growing new field being referred to as epigenetic therapy. To date, 2 classes of drugs have received the most attention, that is, DNA methyltransferase inhibitors and histone deacetylase inhibitors; but recent data suggest that botanical sources may be a rich source of agents that can potentially modulate the epigenome and related pathways and potentially be useful in attenuating the progression of many factors related to development of metabolic syndrome. This review will provide an overview of the field of epigenetics, epigenetic therapy, and the molecules currently receiving the most interest with respect to treatment, and review data on botanical compounds that show promise in this regard.This work was supported in part by NIH Grant P50AT002776-01 from the National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS).NIH P50 AT002776-01; by William CefaluThe published version of this article is available at: http://www.metabolismjournal.com
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No full textDistinguished Alumni Award Program author. LTG David K. Heebner, USA (Ret) (Presented 13 Aug 14)NANAhttp://archive.org/details/adevelopmentndco109451773
Gravel disturbance impacts on salmon habitat and stream health: a report for the Oregon Division of State Lands
No full textVolume I. Summary report -- Volume II. Technical background report.prepared by the Oregon Water Resources Research Institute , authors: Kenneth J. Williamson, Director, OWRRI, David A. Bella, Professor, Civil Engineering, OSU, Robert L. Beschta, Professor, Forest Engineering, OSU, Gordon Grant, Research Hydrologist, USDA Forest Service, Peter C. Klingeman, Professor, Civil Engineering, OSU, Hiram W. Li, Assistant Leader/Professor, OR Cooperative Fishery Research Unit/ Fisheries and Wildlife, OSU, Peter O. Nelson, Professor, Civil Engineering.Title from PDF title page (viewed on November 17, 2020)."March 1995"--Title page (volume 1)."April 1995"--Title page (volume 2).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Post-war British working-class fiction with special reference to the novels of John Braine, Alan Sillitoe, Stan Barstow, David Storey and Barry Hines
No full textThis study is about British working-class fiction in the post-war period.
It covers various authors such as Robert Tressell, George Orwell, Walter Greenwood, Lewis Grassic Gibbon and DH Lawrence from the early twentieth century; writers traditionally classified as 'Angry Young Men' like John Osborne, Arnold Wesker, Shelagh Delaney, John Wain and
Kingsley Amis; and working-class novelists like John Braine, Stan Barstow, David Storey, Alan Sillitoe and Barry Hines from the 1950s and 1960s.
Some of the main issues dealt with in the course of this study are language, form, community, self/identity/autobiography, sexuality and relationship with bourgeois art. The major argument centres on two questions: representation of working-class life, and the
relationship between working-class literary tradition and dominant ideologies.
We will be arguing that while working-class fiction succeeded in challenging and rupturing bourgeois literary tradition, on the level of language and linguistic medium of expression for example, it utterly failed to break away from dominant, bourgeois modes of literary production in relation to form, for instance.
Our argument is situated within Marxist approaches to literature, a political and aesthetic position from which we attempt an analysis and an evaluation of this working-class literary tradition. These critical approaches provide us also with the theoretical tool to define the political perspective of this tradition, and to judge whether it was confined to a descriptive mode of representation or
located in a radical, political outlook
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