1,359,845 research outputs found
Enantioselective <i>N</i>‑Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction
No full textThe development of
an intermolecular and enantioselective aza-Wacker
reaction is described. Using indoles as the N-source
and a selection of alkenols as the coupling partners selective
β-hydride elimination toward the alcohol was achieved. This
strategy preserves the newly formed stereocenter by preventing the
formation of traditionally observed enamine products. Allylic and
homoallylic alcohols with a variety of functional groups are compatible
with the reaction in high enantioselectivity. Isotopic-labeling experiments
support a syn amino-palladation mechanism for this
new class of aza-Wacker reactions
Enantioselective <i>N</i>‑Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction
No full textThe development of
an intermolecular and enantioselective aza-Wacker
reaction is described. Using indoles as the N-source
and a selection of alkenols as the coupling partners selective
β-hydride elimination toward the alcohol was achieved. This
strategy preserves the newly formed stereocenter by preventing the
formation of traditionally observed enamine products. Allylic and
homoallylic alcohols with a variety of functional groups are compatible
with the reaction in high enantioselectivity. Isotopic-labeling experiments
support a syn amino-palladation mechanism for this
new class of aza-Wacker reactions
Codebook and Raw Data for: Wacker, J. & Albrecht, M. Probing the association of a behavioral measure of optimistic bias with depressive symptoms and reward sensitivity
No full textCodebook and Raw Data for: Wacker, J. & Albrecht, M. Probing the association of a behavioral measure of optimistic bias with depressive symptoms and reward sensitivityunknow
Replication files for "Poverty decompositions with counterfactual income and inequality dynamics" (Hartmann and Wacker, 2023)
No full textSTATA files to replicate Hartmann and Wacker (2023) and calculate the poverty counterfactuals discussed therein. An overview about the files is provided in a ReadMe file.</p
[2011.41.082] Portrait of Jacob Wacker and Carl Wacker
No full textFull-length image of Jacob Wacker (on left) and Carl Wacker (on right) standing next to a parlor table and a flower arrangement. Inscribed on frame "Jacob and Carl Wacker." Circa 1910.
Courtesy of Edward and Christina Munsch Berreth Collection, 2011.41, GRHC.Full-length image of Jacob Wacker (on left) and Carl Wacker (on right) standing next to a parlor table and a flower arrangement. Inscribed on frame "Jacob and Carl Wacker." Circa 1910. Courtesy of Edward and Christina Munsch Berreth Collection, 2011.41, GRHC
Asymmetric Aza-Wacker-Type Cyclization of <i>N</i>‑Ts Hydrazine-Tethered Tetrasubstituted Olefins: Synthesis of Pyrazolines Bearing One Quaternary or Two Vicinal Stereocenters
No full textWe
have developed an asymmetric aza-Wacker-type cyclization of N-Ts hydrazine-tethered tetrasubstituted olefins, affording
optically active pyrazolines bearing chiral tetrasubstituted carbon
stereocenters. This reaction is tolerant to a broad range of substrates
under mild reaction conditions, giving the desired chiral products
with high enantioselectivities. Generation of two vicinal stereocenters
on the CC double bonds was also achieved with high selectivities,
a process which has been rarely studied for Wacker-type reactions.
A mechanistic study revealed that this aza-Wacker-type cyclization
undergoes a syn-aminopalladation process. It was
also found that for substrates bearing two linear alkyl substituents
on the outer carbon atom of the olefin, both of which are larger than
a methyl group, the alkyl substituent that is cis to the intranucleophilic group participates more readily in β-hydride
elimination. When one of the two alkyl substituents on the outer carbon
atom of the olefin is a methyl group, β-hydride elimination
proceeds selectively at the methylene side, thus both diastereomers
can be prepared via switching the configuration of the olefin. Furthermore,
the product can be converted to a pharmaceutical compound in high
yields over three steps
Progress Towards the Syntheses of Bactobolin A and C4-epi-Bactobolin A Using a Sulfamate-Tethered Aza-Wacker Cyclization Strategy
No full textWe present a progress report towards Bactobolin A and C4-epi-Bactobolin A. Sulfamate-tethered aza-Wacker cyclization followed by a Tsuji-Wacker ketone synthesis furnishes a key tricyclic intermediate which we hypothesize can be elaborated into C4-epi-Bactobolin A. Epimerization of one of the stereocenters of this compound furnishes an intermediate which we hypothesize can be elaborated into
Bactobolin A
Five minutes with Gudrun Wacker: ‘The Chinese political elite perceive the EU as a successful example of regional integration that has created stability and peace in Europe’
No full textDr. Gudrun Wacker, Senior Fellow at the German Institute for International and Security Affairs, argues that China does not see the EU as an influential geostrategic competitor. Nevertheless, the Chinese political elite considers the EU as a successful example of regional integration which has fostered peace and stability
Wacker Siltronic Project
No full textWacker Siltronic has the majority of its plant capacity consumed at the beginning of a month with forecasted orders or good will orders from customers. However, there is typically some left over capacity that enables Wacker to meet emergency short notice orders from customers. The objective of the Inventory Simulation Program is to determine the minimum inventory requirements for Wacker to meet these random orders in a typical month
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