325,414 research outputs found
George S. Mills residence, architectural drawings, 1895
No full textThese images are a set of architectural drawings done by the Mills and Wachter architectural firm of Toledo, Ohio. The building was commissioned in 1895. The commission number for the project is 0225. These drawings are black line on cream colored linen, and include exterior elevations and floorplans. This was a project by George S. Mills, of Mills and Wachter, to design his own home
Mr. J. M. Ferris Residence, architectural drawings, 1890s
No full textArchitectural drawings for the construction of a residence commissioned by J. M. Ferris and created by the Mills and Wachter architectural firm of Toledo, Ohio. The drawings are mostly black ink on linen and are largely undated, while there are a couple of sketches done in pencil on beige colored paper dated 1900 and 1905. The commission number for this project is listed as 0161, though this accompanies a stamp which simply states "George S. Mills" and may have been applied not during the existence of the Mills and Wachter firm, but instead when Mills was working alone. J. M. Ferris first appears living at this address in city directories in 1897, while the Mills and Wachter firm existed from 1893 to 1897. Most likely most of these drawings were created in 1895 or 1896. The drawings include two sets of plans, one initial proposed set of drawings in sheets 13 - 20, and the plans by which the house was constructed in sheets 1 - 12. The drawings include floorplans for the cellar, first floor, second floor and attic, exterior elevations for all four sides of the building, a site plan, a roof plan, and some interior detail drawings. As of 2019 this residence has not been demolished
George S. Mills residence, exterior views, 2019
No full textThese images are exterior views of a house designed by the Mills and Wachter architectural firm of Toledo, Ohio. The building was commissioned in 1895. The photographs were taken on March 19, 2019
Mouratidi, Katharina (2006): Venceremos! Die andere Globalisierung. Heidelberg: Wachter Verlag, 128 S. [Rezension]
No full textRezension zu: Mouratidi, Katharina (2006): Venceremos! Die andere Globalisierung. Heidelberg: Wachter Verlag, 128 S., ISBN 978-3-89904-220-
Cancer biomarkers detection in cell lysates by means of anisotropic fluorescence at the surface of 1D photonic crystal biochips
No full textNovel disposable optical biochips based on one-dimensional photonic crystals (1DPC) sustaining Bloch surface waves (BSW) are an attractive tool for the detection of several disease-related biomarkers. In response to growing global burden of cancer, one of the most significant public health challenges of the 21st century is the prevention and early diagnosis of this disease. By diagnosing in advance such disease permits to increase the survival probability of patients and to improve their life perspectives. Consequently, cancer biomarkers have gained considerable attention. Within this framework, the herein proposed optical biochips can quantify low concentrations (sub ng/mL) of the ERBB2 breast cancer biomarker in biological complex matrices, such as cell lysate samples. The choice of focusing on this specific breast-cancer-related biomarker lies in the global issue represented by this type of cancer. According to the data provided by the World Cancer Research Fund, its incidence rate increases year per year establishing itself as the most commonly occurring cancer in women worldwide contributing 25% of the total number of new cases diagnosed in 2018 and as the second most common cancer overall after lung cancer. However, the versatility of the system opens up new possibilities for designing different assays, depending on the specific biomarker sought.
To discriminate ERBB2 levels in several different cell lysate samples, we made use of 1DPC biochips and on a reading instrument that can work in both a label-free and a fluorescence detection mode. Such combined configuration provides the advantage of complementary information and lower limit of detection (LoD) in the fluorescence mode. In the label-free mode, the BSW excitation is achieved by a prism coupling system (Kretschmann-Raether configuration), like in the surface plasmon resonance (SPR) technique, resulting in a dip in the angular reflectance spectrum. According to the interactions that take place at the surface, the angular position of such a dip shifts as a function of refractive index change at the interface.
Moreover, the fluorescence operation, in which fluorescence angular spectra are acquired, is obtained by making use of fluorophores or dye labelled antibodies bound at the 1DPC surface. Furthermore, coupling between the dye labels and the BSW results in strongly directional and enhanced fluorescence emission. The advantages brought by the 1DPC, when compared to metal structures, are the smaller energy losses and the narrower resonances.
Despite the great sensitivity offered by the fluorescence detection mode, the measurements are affected by a phenomenon that cannot be neglected when quantitative and accurate information is needed, as occurs in biosensing assays, i.e. photobleaching. Presently, there is no study about photobleaching in experiments with BSW sustained by 1DPC, despite its evident effects. Photobleaching denotes the irreversible loss of fluorescence emitted energy of a dye that dramatically changes its absorption and emission properties. The rate of such a fluorescence bleaching is affected by several factors such as the power of the illumination beam, the exposure time, and the photonic crystal structure itself. In addition, it is also influenced by the molecule’s transition dipole moment. In particular, fluorophores having a transition dipole moment oriented parallel to excitation polarized light will be excited preferentially, and in turn will be strongly photobleached. As a consequence, the fluorescence emission will be polarized and no more isotropic. This effect is more or less significant depending on the binding strength of the fluorophores to the surface.
In this dissertation, we report for the first time on cancer detection assays, carried out with our setup, in which the trustworthiness is guaranteed by a correct approach to data analysis, which accounts in a correct way for photobleaching, which could not only affect the overall emission intensity but also its polarization distribution via the TE and TM BSW modes provided by the 1DPC.
To get to such a result, the experimental data is interpreted by means of a theoretical model for the orientational distribution of dye labels over time, taking into account the density of the optical states of the 1DPC, photobleaching and rotational diffusion of surface bound emitters. The approach permits to model anisotropic fluorescence emission and to manage photobleaching effects in biosensing assays, leading to a correct data interpretation.
The theoretical description permits not only to manage photobleaching but also to exploit it as a new tool for probing rotational diffusion of any protein labelled with fluorescent emitters at the surface of 1DPC endowed with different chemistries. Such a possibility is related to the polarization dependent spectroscopic role played by the 1DPC, which permits to analyse simultaneously two polarizations, TE and TM, within a relatively simple optical layout and thus accessing either the orientation or the depolarization kinetics under non-stationary conditions of the resonant fluorescence signal. Such a type of measurement is not possible with conventional fluorescence anisotropy techniques or using other types of surface electromagnetic waves, such as surface plasmon polaritons, for example, that are only TM polarized
Probe einer Übersetzung der Eddalieder in Runenreimen
No full textPROBE EINER ÜBERSETZUNG DER EDDALIEDER IN RUNENREIMEN
Probe einer Übersetzung der Eddalieder in Runenreimen (6)
II. Probe einer Uebersetzung der Eddalieder in Runenreimen *), von Ferdinand Wachter. (6
Did smallpox reduce height?: stature and the standard of living in London, 1770-1873.
No full textIn this paper, we re-examine the effect of smallpox on the height attained by those who suffered from this disease. To this end, we analyse a dataset assembled by Floud, Wachter and Gregory on the height of recruits into the Marine Society, 1770-1873. Using both time series and cross-sectional analysis, we show that smallpox was indeed an important determinant of height: those who had suffered from smallpox were significantly shorter. This suggests that the increase in heights documented by Floud et al. may be explained not just by increased nutritional intake, but also by the eradication of smallpox.
S Mark Gubb - Revelations
No full textA 200-page publication that functioned as a more fully rounded publication-version of the 'Revelations' survey exhibition staged at SYSON Gallery. This was not an exhibition catalogue, but a publication covering nearly 20 years of practice and was designed to sit, visually and thematically, within the wider ‘Revelations’ project. The book was designed by Hugh Frost (Landfill Editions) and Blue Firth and contained essays written by Jonathan Griffin and Ellen Mara De Wachter, along with the transcript of an interview between myself and, the artist, Professor Ross Sinclair (Glasgow School of Art)
Erinnerungskultur digital. Die Ortlosigkeit virtueller Räume als Katharsis postmodernen Gedenkens
No full textHaas S, Wachter C. Erinnerungskultur digital. Die Ortlosigkeit virtueller Räume als Katharsis postmodernen Gedenkens. INDES. Zeitschrift für Politik und Gesellschaft. 2018;7(2):27–32
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
- …
