1,721,010 research outputs found
Advancements in renal protection
Get PDFChronic kidney disease is a rising worldwide public health problem. The prevention of progressive renal function loss of both native and transplanted kidneys is therefore the main challenge in current clinical nephrology. Blockade of the renin-angiotensin aldosterone system (RAAS) with blood pressure and proteinuria lowering medication is standard treatment for patients with chronic kidney disease. However, as many patients still suffer ongoing renal function loss apparently the renoprotective effect of the current RAAS-blockade based regimens remains incomplete. This prompts for optimization of RAAS-blockade based therapy to provide better renoprotection. This thesis shows advancements in the efficacy of renoprotective intervention of RAAS blockade by combined intervention in sodium status by sodium restriction and diuretic treatment. We also show that aldosterone receptor blockade is a promising tool to improve renoprotective intervention in native and transplanted kidney disease.
Additional modes of intervention that directly target other pathophysiological pathways involved in kidney disease might be useful. In this thesis we investigated whether intervention in advanced glycation end products (AGEs; glycated proteins) can exert renoprotective effects. Whether the AGE formation inhibitor pyridoxamine exerted renoprotective or nephrotoxic effects, depended on the studied animal model of renal damage. Based on the results of this thesis, we caution to study pyridoxamine in renal patients, especially when combining pyridoxamine with blockade of the RAAS. At present, RAAS blockade remains the cornerstone of renoprotective therapy; control of sodium status is important to optimize its effects.
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Advancements in renal protection
Get PDFChronic kidney disease is a rising worldwide public health problem. The prevention of progressive renal function loss of both native and transplanted kidneys is therefore the main challenge in current clinical nephrology. Blockade of the renin-angiotensin aldosterone system (RAAS) with blood pressure and proteinuria lowering medication is standard treatment for patients with chronic kidney disease. However, as many patients still suffer ongoing renal function loss apparently the renoprotective effect of the current RAAS-blockade based regimens remains incomplete. This prompts for optimization of RAAS-blockade based therapy to provide better renoprotection. This thesis shows advancements in the efficacy of renoprotective intervention of RAAS blockade by combined intervention in sodium status by sodium restriction and diuretic treatment. We also show that aldosterone receptor blockade is a promising tool to improve renoprotective intervention in native and transplanted kidney disease. Additional modes of intervention that directly target other pathophysiological pathways involved in kidney disease might be useful. In this thesis we investigated whether intervention in advanced glycation end products (AGEs; glycated proteins) can exert renoprotective effects. Whether the AGE formation inhibitor pyridoxamine exerted renoprotective or nephrotoxic effects, depended on the studied animal model of renal damage. Based on the results of this thesis, we caution to study pyridoxamine in renal patients, especially when combining pyridoxamine with blockade of the RAAS. At present, RAAS blockade remains the cornerstone of renoprotective therapy; control of sodium status is important to optimize its effects
Advancements in renal protection
Get PDFChronic kidney disease is a rising worldwide public health problem. The prevention of progressive renal function loss of both native and transplanted kidneys is therefore the main challenge in current clinical nephrology. Blockade of the renin-angiotensin aldosterone system (RAAS) with blood pressure and proteinuria lowering medication is standard treatment for patients with chronic kidney disease. However, as many patients still suffer ongoing renal function loss apparently the renoprotective effect of the current RAAS-blockade based regimens remains incomplete. This prompts for optimization of RAAS-blockade based therapy to provide better renoprotection. This thesis shows advancements in the efficacy of renoprotective intervention of RAAS blockade by combined intervention in sodium status by sodium restriction and diuretic treatment. We also show that aldosterone receptor blockade is a promising tool to improve renoprotective intervention in native and transplanted kidney disease. Additional modes of intervention that directly target other pathophysiological pathways involved in kidney disease might be useful. In this thesis we investigated whether intervention in advanced glycation end products (AGEs; glycated proteins) can exert renoprotective effects. Whether the AGE formation inhibitor pyridoxamine exerted renoprotective or nephrotoxic effects, depended on the studied animal model of renal damage. Based on the results of this thesis, we caution to study pyridoxamine in renal patients, especially when combining pyridoxamine with blockade of the RAAS. At present, RAAS blockade remains the cornerstone of renoprotective therapy; control of sodium status is important to optimize its effects
Advancements in renal protection
Get PDFChronic kidney disease is a rising worldwide public health problem. The prevention of progressive renal function loss of both native and transplanted kidneys is therefore the main challenge in current clinical nephrology. Blockade of the renin-angiotensin aldosterone system (RAAS) with blood pressure and proteinuria lowering medication is standard treatment for patients with chronic kidney disease. However, as many patients still suffer ongoing renal function loss apparently the renoprotective effect of the current RAAS-blockade based regimens remains incomplete. This prompts for optimization of RAAS-blockade based therapy to provide better renoprotection. This thesis shows advancements in the efficacy of renoprotective intervention of RAAS blockade by combined intervention in sodium status by sodium restriction and diuretic treatment. We also show that aldosterone receptor blockade is a promising tool to improve renoprotective intervention in native and transplanted kidney disease. Additional modes of intervention that directly target other pathophysiological pathways involved in kidney disease might be useful. In this thesis we investigated whether intervention in advanced glycation end products (AGEs; glycated proteins) can exert renoprotective effects. Whether the AGE formation inhibitor pyridoxamine exerted renoprotective or nephrotoxic effects, depended on the studied animal model of renal damage. Based on the results of this thesis, we caution to study pyridoxamine in renal patients, especially when combining pyridoxamine with blockade of the RAAS. At present, RAAS blockade remains the cornerstone of renoprotective therapy; control of sodium status is important to optimize its effects
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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