1,722,434 research outputs found
博物新編 = Bo wu xin bian
No full textOn double leaves, oriental style西醫五種包括 : 全體新論, 博物新編, 西醫略論, 婦嬰新說, 內科新說 = Xi yi wu zhong bao kuo : Quan ti xin lun, Bo wu xin bian, Xi yi lue lun, Fu ying xin shuo, Nei ke xin shuoThomas Chong Collection. Gift of Dr Dorothy Chong and family, 199
博物新編 = Bo wu xin bian
No full textOn double leaves, oriental style西醫五種包括 : 全體新論, 博物新編, 西醫略論, 婦嬰新說, 內科新說 = Xi yi wu zhong bao kuo : Quan ti xin lun, Bo wu xin bian, Xi yi lue lun, Fu ying xin shuo, Nei ke xin shuoThomas Chong Collection. Gift of Dr Dorothy Chong and family, 199
[Wu xin wen shu 五 辛 文 書.]
No full textWu xin wen shu 五 辛 文 書. Médecine, pharmacopée, botaniqueNumérisation effectuée à partir d'un document original.Déb. et fin manquent. Titre d'après le Pelliot chinois 3777 comprenant une copie plus complète. Traité bouddhique de morale, présenté sous la forme allégorique d'un traité médical. Écr. kai à tendance xing. Encre noire. Additions, ratures et corrections. 53 col., 24 et 29 col. par f., 26 car. environ par col. Notes sur col. dédoublées. Marge inf. 0,1 cm. Réglures par pliage
Data for the estimation of the earth resistivity model for the ATEM observation
No full textUseful signal data and noise data for training neural network，which will be used for estimating the earth resistivity model for the ATEM observation. Each line in the data files is a training sample with Sampling rate 128 kHz
Exploitation of noncovalent/dynamic covalent interactions in sensing, self-assembly and membrane transport
No full textThis thesis reports the development of several novel chemical sensing systems, self-assembled aggregates, and membrane transporters in which noncovalent and/or dynamic covalent interactions operate.Perylenebisimide dyes functionalized with boronic acid groups were designed as effective chirality sensors for [alpha]-hydroxy carboxylates. Binding of chiral ?-hydroxy carboxylate guests via boronate ester linkage leads to formation of optically active helical stacks of perylenebisimide dyes in water, giving diagnostic induced circular dichroism signals in the perylene absorption region.A boronic acid-functionalized pyrene fluorophore forms excimer-emissive stacks upon cooperative binding of fluoride ion and catechol to the boron centre, allowing sensitive sensing of fluoride at ppm levels in aqueous solution which was unprecedented for boronic acids. The stabilization of boron-fluoride adduct in the aggregate and increase of Lewis acidity via catechol binding were proposed responsible for the unprecedented affinity, as supported by control experiments.A dynamic covalent amphiphile comprised of 4-formylphenylboronic acid and octylamine forms vesicular aggregates selectively with glucose which can bind two boronic acids thus forming “Gemini-type” amphiphiles. The aggregates feature stabilization of imine bond and boronate ester linkage, with the two dynamic covalent bonds working in synergy promoting the formation of each other despite the spatial separation. The system allows selective sensing of glucose against the interference of fructose, for the first time without resorting to any synthesis.A dynamic covalent approach was employed to transmembrane transport of amino acids by the formation of a three-component assembly. A mixture of a squaramide and a lipophilic and electrophilic aldehyde is shown to synergistically transport glycine across phospholipid vesicle membranes. The transport is proposed to occur via a hydrogen-bonded anionic glycine hemiaminal/imine, with control experiments supporting the role of hemiaminal/imine in the observed facilitated glycine transportFinally, the issue of electrogenic/electroneutral transport mechanisms and potential proton or hydroxide transport for synthetic anionophores were examined. It is shown that depending on acidity, many synthetic anionophores can facilitate electrogenic proton or hydroxide transport. However, two newly-developed small molecules are shown to promote chloride transport without significant proton/hydroxide transport (pH gradient dissipation) at low concentrations, essentially mimicking the electrogenic cationophore valinomycin. The chloride > proton/hydroxide selective anionophores feature encapsulation of chloride ion via weak hydrogen or halogen bonds
Small molecule uncoupling protein mimics: synthetic anion receptors as fatty acid-activated proton transporters
No full textUncoupling proteins (UCPs) regulate energy expenditure in living cells by inducing proton leakage across the mitochondrial inner membrane, thereby uncoupling ADP phosphorylation from nutrient oxidation. The proton transport activity of UCP1 and UCP2 requires activation by fatty acids. We report here the first examples of synthetic small molecules performing this biologically important fatty acid-activated function. We have shown that a tripodal thiourea possesses poor H+/OH? transport activity without fatty acids, but in the presence of long-chain fatty acids is “switched on” as a proton transporter with an activity close to a commonly used protonophore. The fatty acid-enhanced proton transport was also observed for other hydrogen and halogen bond-based synthetic anion transporters. We propose that these compounds induce proton permeability by catalyzing transbilayer movement (“flip-flop”) of anionic fatty acids, so allowing the fatty acids to complete a proton transport cycle. Several lines of evidence have been provided to support such a fatty acid cycling mechanism. Our findings open up new applications of anion receptor chemistry, and provide important clues for understanding biological activities of synthetic anion transporters and potentially the uncoupling mechanism of naturally occurring membrane proteins
Using Rough Set and Electrical Capacitance Tomograph ( ETC ) for Identification of Gas-solid Two-phase Flow Regimes
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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