1,721,103 research outputs found
RRS Challenger Cruise 12/79, 18 August - 7 September 1979. Geological investigations in the northern North Sea and on the continental shelf west and north of Scotland. Recovery and relaying of current meter moorings south and west of the Wyville-Thomson Ridge
Get PDFRRS Discovery Cruise 123, 5th August - 10th September 1981. Geological investigations on the continental slope to the west of the British Isles and Norway
Get PDFRRS Challenger Cruise 9/81, 16 June - 1 July 1981. Sediment and faunal investigations on the continental shelf to the west and north of Scotland
Get PDFRRS Challenger Cruise 14/74 (legs 1 and 2), 29 August - 21 September 1974. Geological investigations on the continental shelf to the west and north of Scotland
Get PDFRRS Frederick Russell Cruise 7/83, 21 April - 13 May 1983. Sediment and faunal investigations on the continental shelf and upper continental slope west and north of Scotland and in the Irish Sea
Get PDFConsiderations in generating transgenic mice: DNA, RNA, and protein extractions from tissues–rapid and effective blotting
No full textThe mouse provides a powerful system to produce and study models of human disease. The ability to introduce, inactivate, or modify genes in mice has significantly advanced our understanding of molecular and cellular disease processes. New tools and novel applications of the classic techniques now permit spacial and temporal restrictions to be applied to in vivo gene expression. In this chapter, the expansive methods used to generate transgenic mice will not be presented as there are several comprehensive books on the topic, including one in this series (1,2). In addition, the legislative requirements for working with animals will not be described here; suffice it to mention that transgenic animal production is a licensed procedure within the UK. Instead, considerations relating specifically to the application of transgenic techniques to studying Epstein-Barr virus (EBV)-associated diseases will be discussed
Separation of epidermal tissue from underlying dermis and primary keratinocyte culture
No full textThe epidermis shares many structural similarities to other epithelia throughout the body. All epithelia function as a barrier protecting the internal organs. The epidermis of the skin protects the exterior of the body, whereas other forms of epithelia line the airways, blood vessels, and gastrointestinal, urinary, and reproductive tracts. Some glandular epithelia secret substances such as sweat, mucus, and hormones. All epithelia are avascular and consist of closely packed cells, which are tightly attached to one another via cell junctions. This tight structure allows all epithelia to closely regulate the movement of materials such as ions, nutrients, and secretory product
Selection and enrichment of B cells from lymphoid tissues
No full textTransgenic mouse models that express Epstein-Barr virus (EBV) latent proteins in the B-cell compartment provide useful models to study the effects of these proteins at each stage of B-cell development and differentiation. In addition, many aspects of the murine immune system have been extensively studied and are similar to those of the human immune system
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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