173,805 research outputs found
New and old species of Ommatius Wiedemann (Diptera: Asilidae) from Hispaniola
No full textFour new species of Ommatius Wiedemann, the female of O. stramineus Scarbrough, and the male of 0. nigellus Scarbrough from Hispaniola are described. A lectotype for O. gwenae Scarbrough and a neotype for O. cinnamomeus are selected. Notes of previously named species, new records, illustrations of terminalia, and a key to the species are included
Den Herrn Wie er bey den Schilden erhöhet ist, Suchet An denen theils vergangenen, theils instehenden Geburts-Festen Des Durchlauchtigsten Fürsten und Herrn, Herrn Franz Josias, Herzogens zu Sachsen, Jülich, Cleve und Berg, ... wie auch Der Durchlauchtigsten Fürstin und Frau, Frauen Anna Sophia, Vermählter Herzogin zu Sachsen, Jülich, Cleve und Berg, ... gebohrner Fürstin von Schwartzburg : Den 25. Sept. 1744 / Zur Erbauung vorzustellen Deroselben Treu-verbundenster Bruder und Schwager Christian Ernst, H. z. S. C. u. S.
No full textGeburtstagsglückwunsch auf Franz Josias, Herzog zu Sachsen-Coburg und Anna Sophie, Herzogin zu Sachsen-Coburg, 9. und 25. Sept. 1744Autopsie nach Exemplar der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Salfeld, druckts Johann Chrsitian Otto Wiedemann, Fürstl. Sächs. Hof-Buchdrucker
Genomic imprinting defects in the growth disorder Beckwith-Wiedemann syndrome
No full textThe imprinting control region (IC1) of the human IGF2 and H19 genes is represented by a chromatin insulator located between the two genes that prevents the activation of IGF2 and allows the activation of H19 on the maternal chromosome. Deletions removing part of IC1 have been found in patients affected by the overgrowth- and tumour-associated Beckwith–Wiedemann syndrome (BWS). These mutations result in the hypermethylation of the remaining IC1 region and loss of IGF2/H19 imprinting. However, other IC1 microdeletions are associated with incompletely penetrant phenotypes and do not affect the methylation of the locus. Our results indicate that the mutant IC1 alleles with abnormally longer cluster of sites for CTCF have reduced affinity for this factor with respect to the alleles with spacing similar to the wild type sequence, suggesting that the organization rather than the number of CTCF sites in the deleted alleles is critical for the gain of methylation and loss of insulator function. Furthermore, a detailed methylation analysis of BWS patients with IC1 hypermethylation and no accompanying deletion showed that the abnormal methylation is mosaic in the majority of the cases and can affect either the entire or only the 3’ half of the regulatory region. In these cases, the epimutation and the phenotype did not cosegregate with the 11p15.5 region. In both the cases with the microdeletions and those without sequence change, the epigenetic abnormalities are usually present in the patients in the mosaic form and probably acquired by post-zygotic de novo methylation
Methylation analysis and diagnostics of Beckwith-Wiedemann syndrome in 1,000 subjects
No full textBackgroundBeckwith-Wiedemann syndrome (BWS), a congenital overgrowth disorder with variable expressivity and a predisposition to tumorigenesis, results from disordered expression and/or function of imprinted genes at chromosome 11p15.5. There are no generally agreed clinical diagnostic criteria, with molecular studies commonly performed to confirm diagnosis. In particular, methylation status analysis at two 11p15.5 imprinting control centres (IC1 and IC2) detects up to 80% of BWS cases (though low-level mosaicism may not be detected). In order to evaluate the relationship between the clinical presentation of suspected BWS and IC1/2 methylation abnormalities we reviewed the results of >1,000 referrals for molecular diagnostic testing. ResultsOut of 1,091 referrals, 507 (46.5%) had a positive diagnostic test for BWS. The frequency of tumours was 3.4% in those with a molecular diagnosis of BWS. Previously reported genotype-phenotype associations with paternal uniparental disomy, IC1, and IC2 epimutation groups were confirmed and potential novel associations detected. Predictive values of previously described clinical diagnostic criteria were compared and, although there were differences in their sensitivity and specificity, receiver operating characteristic (ROC) analysis demonstrated that these were not optimal in predicting 11p15.5 methylation abnormalities. Using logistic regression, we identified clinical features with the best predictive value for a positive methylation abnormality. Furthermore, we developed a weighted scoring system (sensitivity 75.9%, and specificity 81.8%) to prioritise patients presenting with the most common features of BWS, and ROC analysis demonstrated superior performance (area under the curve 0.85, 95% CI 0.83 to 0.87) compared to previous criteria. ConclusionsWe suggest that this novel tool will facilitate selection of patients with suspected BWS for routine diagnostic testing and so improve the diagnosis of the disorder. <br/
Rhinomyza Wiedemann 1820
No full text37. Rhinomyza Wiedemann, 1820a: 8. ORIGINALLY INCLUDED SPECIES: Rhinomyza fusca Wiedemann, 1820. TYPE SPECIES: Rhinomyza fusca Wiedemann, 1820, by monotypy. CURRENT STATUS: Valid genus [teste Sabrosky (1999: 268)]. FAMILY: TABANIDAE.Published as part of EVENHUIS, NEAL L. & PONT, ADRIAN C., 2013, Nomenclatural studies toward a world catalog of Diptera genus-group names. III. Christian Rudolph Wilhelm Wiedemann, pp. 1-75 in Zootaxa 3638 (1) on page 36, DOI: 10.11646/zootaxa.3638.1.1, http://zenodo.org/record/526261
Acanthina Wiedemann 1830
No full text1. Acanthina Wiedemann, 1830a: 50. ORIGINALLY INCLUDED SPECIES: Acanthina hieroglyphica Wiedemann, 1830; Acanthina longa Wiedemann, 1830; Clitellaria elongata Wiedemann, 1824. TYPE SPECIES: Clitellaria elongata Wiedemann, 1824, by subsequent designation (Duponchel in d’Orbigny, 1839: 29). CURRENT STATUS: Preoccupied by Fischer, 1807; senior (but invalid) synonym of Acanthinomyia Hunter, 1900 [teste Woodley (2001: 79)]. FAMILY: STRATIOMYIDAE.Published as part of EVENHUIS, NEAL L. & PONT, ADRIAN C., 2013, Nomenclatural studies toward a world catalog of Diptera genus-group names. III. Christian Rudolph Wilhelm Wiedemann, pp. 1-75 in Zootaxa 3638 (1) on page 25, DOI: 10.11646/zootaxa.3638.1.1, http://zenodo.org/record/526261
Longina Wiedemann 1830
No full text20. Longina Wiedemann, 1830a: 553. ORIGINALLY INCLUDED SPECIES: Longina abdominalis Wiedemann, 1830. TYPE SPECIES: Longina abdominalis Wiedemann, 1830, by monotypy. CURRENT STATUS: Valid genus [teste Steyskal (1968a: 3)]. FAMILY: NERIIDAE. [Loniatia] Wiedemann, 1828: 292. CURRENT STATUS: Incorrect subsequent spelling of Lomatia Meigen, 1822. FAMILY: BOMBYLIIDAE. REMARKS: This misspelling was corrected in the errata in Wiedemann (1828: 604).Published as part of EVENHUIS, NEAL L. & PONT, ADRIAN C., 2013, Nomenclatural studies toward a world catalog of Diptera genus-group names. III. Christian Rudolph Wilhelm Wiedemann, pp. 1-75 in Zootaxa 3638 (1) on page 30, DOI: 10.11646/zootaxa.3638.1.1, http://zenodo.org/record/526261
Plagiocephalus Wiedemann 1830
No full text28. Plagiocephalus Wiedemann, 1830b: 12. ORIGINALLY INCLUDED SPECIES: Plagiocephalus lobularis Wiedemann, 1830. TYPE SPECIES: Plagiocephalus lobularis Wiedemann, 1830, by monotypy. CURRENT STATUS: Valid genus [teste Steyskal (1968b: 21)]. FAMILY: ULIDIIDAE. [Platura] Wiedemann in Meigen, 1826: vi. CURRENT STATUS: Incorrect subsequent spelling of Platyura Meigen, 1803. FAMILY: KEROPLATIDAE. REMARKS: Criteria to make this name available as an emendation were not found to be fulfilled in this work.Published as part of EVENHUIS, NEAL L. & PONT, ADRIAN C., 2013, Nomenclatural studies toward a world catalog of Diptera genus-group names. III. Christian Rudolph Wilhelm Wiedemann, pp. 1-75 in Zootaxa 3638 (1) on pages 33-34, DOI: 10.11646/zootaxa.3638.1.1, http://zenodo.org/record/526261
Polymera Wiedemann
No full textSubgenus Polymera Wiedemann Polymera Wiedemann, 1820: 40 (as genus). Type species, Chironomus hirticornis Fabricius, 1805 (monotypic).Published as part of Ribeiro, Guilherme C. & Santos, Daubian, 2016, FAMILIES TIPULIDAE AND LIMONIIDAE, pp. 73-97 in Zootaxa 4122 (1) on page 84, DOI: 10.11646/zootaxa.4122.1.14, http://zenodo.org/record/25830
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