1,720,959 research outputs found
RENOPROTECTIVE POTENTIAL OF FLAVONOIDS-RICH AGAINST DOXORUBICIN-INDUCED IN ANIMAL MODELS: A REVIEW
No full textCancer significantly impacts human health, affecting one in five people during their lifetime. While chemotherapeutic agents like doxorubicin are crucial in treating various cancers, they are also associated with severe side effects, including nephrotoxicity. This review examines the renoprotective potential of flavonoids against doxorubicin-induced renal damage in animal models. Doxorubicin works by intercalating Deoxyribo Nucleic Acid (DNA) and making Reactive Oxygen Species (ROS), which cause apoptosis and the death of cells. A thorough literature analysis was done to collect relevant papers on the impact of flavonoid-rich therapies as renoprotective agents against doxorubicin-induced nephrotoxicity. Databases such as Google Scholar, Scopus, PubMed, Springer, Wiley Online Library, and ScienceDirect were searched using keywords including "flavonoids, doxorubicin, renoprotective, nephrotoxicity, and animal model," focusing on publications from 2014 to 2024. Flavonoids are diverse polyphenolic compounds in many plants with significant pharmacological properties such as antioxidant, anti-inflammatory, and anticancer effects. This review highlights the renoprotective potential of flavonoids like quercetin, rutin, kaempferol, morin, luteolin, apigenin, hesperidin, naringenin, diosmin, and anthocyanins. These compounds reduce renal toxicity through mechanisms that decrease ROS, lipid peroxidation, mitochondrial permeability, and apoptosis
Moringa oleifera Leaf Extract and (Amorphophallus muelleri Blume.) Glucomannan Effects on Obese White Rat Feed Intake and Body Weight
Get PDFObesity significantly raises the rates of illness and death in humans due to its association with several health conditions such as cardiovascular disease, hypertension, hypercholesterolemia, type 2 diabetes mellitus, osteoporosis, depression, breast cancer, and colon cancer. This study aims to determine the effect of Moringa oleifera leaf extract and glucomannan (Amorphophallus muelleri Blume.) on feed intake and body weight of obese white rats. This study used an experimental method with a pretest-posttest-only control grub design using 24 white male rats of the Wistar strain aged 8 weeks which were divided into 2 control groups, namely positive(K1) and negative(K2) and six treatment groups with extract doses Moringa oleifera leaves and glucomannan (Amorphophallus muelleri Blume.) 100mg/kgBW:100mg/kgBW(K3), 80mg/kgBW:120mg/kgBW(K4), 120mg/kgBW: 80mg/kgBW(K5), 50mg/kgBW:50mg/kgBW(K6), 40mg/kgBW:60mg/kgBW(K7), and 60mg/kgBW:40mg/kgBW(K8). Data analysis on body weight and feed intake used the SPSS ANOVA test and paired T-test. The results of the paired T-test (p<0.05) showed that Moringa oleifera leaf extract and glucomannan (Amorphophallus muelleri Blume.) significantly reduced body weight and feed intake. In conclusion, administration of Moringa oleifera leaf extract and glucomannan (Amorphophallus muelleri Blume.) in group K4 (80 mg/kgBW Moringa oleifera leaf extract: 120 mg/kgBW glucomannan Amorphophallus muelleri Blume) can reduce feed intake (4.29 g) and body weight (36.67 g) effectively
Combination effectiveness of glucomannan and moringa oleifera leaf extract on lipid profil of hypercholesterolemia rats
No full textcholesterol levels in the blood. This study aims to determine the effectiveness of the combination of glucomannan (Amorphophallus muelleri Blume) and Moringa oleifera leaf extract on the lipid profile of hypercholesterolemic Wistar rats. This research design used True experimental with a pretest-posttest control group design. The animal used in this study was 24 male Wistar rats (Rattus norvegicus) aged 8 weeks divided into 2 control groups and 6 treatment groups of glucomannan and Moringa oleifera leaf extract. The results of this study showed that there were significant changes in TC, TG, LDL-C, and HDL-C levels (p<0.05). It can be concluded that the combination of glucomannan (Amorphophallus muelleri Blume) and Moringa oleifera leaf extract can change the lipid profile effectively in the P5 (80mg/kgBW GAmB: 120mg/kgBW MoEL) and P4 (120mg/kgBW GAmB:80mg/kgBW MoEL ) as the most influential group in reducing TG, TC, LDL-C levels and increasing HDL-C levels
MOLECULAR DOCKING AND PHARMACOKINETIC EVALUATION OF NANOHERBAL SENDUDUK BULU (MICONIA CRENATA (VAHL.) MICHELANG.) COMPOUNDS AS AKT1 INHIBITORS
No full textObjective: This study seeks to investigate the potential of 36 nanoherbal compounds extracted from senduduk bulu (Miconia crenata (Vahl) Michelang.) as inhibitors of v-akt murine thymoma viral oncogene homolog 1 (AKT1) using molecular docking techniques, pharmacokinetic analysis, safety evaluation, and bioactivity assessment.
Methods: Senduduk bulu leaves were nanoparticle-processed and analyzed via Gas Chromatography-Mass Spectrometry (GC-MS). Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiles and biological activities were predicted, and molecular docking assessed compound interactions with AKT1 using borussertib as a reference.
Results: Findings indicate that 20 out of 36 compounds meet the criteria as drug candidates, demonstrating favorable interactions with the AKT1 protein, although their affinity did not surpass that of the positive control, borussertib. Several compounds exhibited high oral bioavailability, showed no interaction with the liver enzyme Cytochrome P450 2D6 (CYP2D6), and did not inhibit the Organic cation transporter 2 (OCT2) protein in the kidneys. In terms of toxicity, these compounds displayed a range of effects, from non-hazardous to hazardous, with some potentially posing risks of hepatotoxicity, carcinogenicity, and mutagenicity.
Conclusion: This research highlights the potential of nanoherbal senduduk bulu in cancer therapy development; however, further validation through in vitro and in vivo studies is necessary to comprehensively ensure their efficacy and safety
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
