290 research outputs found

    Letter to E. C. McCarty from John S. Watts

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    Letter to E. C. McCarty from John S. Watts, former judge, attorney, Santa Fe, regarding what he had found out about the estate of his deceased brother, Isaac McCarty. Watts had not received any letters or payment from the McCarty family to do the investigation thus far. He learned that the partner Ceran St. Vrain and Preston Beck were both away for month. St. Vrain had paid the debts of McCarty amounting to 22,000fromtheassetsoftheproperty,valuedat22,000 from the assets of the property, valued at 30.000, the remaining could be divided between St. Vrain and the family. There was also a contract for flour with the goverment, the value of which was unknown. Watts did not want to proceed further without authorization and promise of compensation. A transcript in the handwriting of the author. Document in English, 3 pp/fr, missing heading page

    The Woman Diver and the Dragon Ball

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    A Noh play and temple chronicle, thought to have prehistoric origins in one of the oldest professions, was translated for the Shikoku Bilingual Guidebook by Akiko Takemoto and Steve McCarty. The co-author narrates this podcast, telling the heart-wrenching story of a woman's ultimate sacrifice, with an overlay of Buddhism and archetypal symbolism. After the story, some discussion questions are suggested to have listeners consider the significance of the story and the East Asian cultural value conflicts involved

    二言語による子育てに関する著述 (Interviews & articles in Japanese on bilingual child-raising)

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    Main magazine & online interviews and articles on bilingual child-raising by the author in Japanese from 2007-2010: 1) 「いつ話すかな?英語の言葉」 [When will children start speaking English? - Interview with the author and H. Toyota of Tokyo University of Technology], 2) 「英語を子ども自身の第二言語にする方法」 [How to make English a child’s second language], 3) 「インターネットでできる英語体験」[Experiencing English through the Internet], 4) 「日本でできるグローバル体験~英語や異文化の取り入れ方~」 [Global experiences in Japan by encountering English & other cultures], and 5) 「Steve A. McCarty先生インタビュー」[Interview with the author]. Tokyo: Benesse (an educational information corporation)

    James Watson, Maclyn McCarty, and Torsten Wiesel

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    Torsten Wiesel (right) with Professor Emeritus Maclyn McCarty (center), co-author of the paper with Oswald Avery and Colin MacLeod, and James D. Watson, director of Cold Spring Harbor Laboratory, 1994 Photo by Leif Carlsson To commemorate the fiftieth anniversary of the discovery at The Rockefeller University that genes are made of DNA - considered by many to be the single most important biological discovery of the twentieth century - the university has kicked off a year-long series of events that were running through May 1994. The celebration was formally inaugurated in November 1993 with a lec­ture by Nobel laureate James D. Watson, best known for discovering the double-helical structure of DNA. See also Search Winter 1994, vol. 4, no. 1https://digitalcommons.rockefeller.edu/group-portraits/1013/thumbnail.jp

    Let Yez All Be Irish Tonight

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    First Line: Michael McCarty once gave a big partyFirst Line of Chorus: Let yez all be Irish tonight wow!Key: E Flat Majo

    Pharmacogenetics of ophthalmic topical β-blockers

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    Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure. Genetic variability has been postulated to contribute to interpersonal differences in efficacy and safety of topical β-blockers. This review summarizes clinically significant polymorphisms that have been identified in the β-adrenergic receptors (ADRB1, ADRB2 and ADRB3). The implications of polymorphisms in CYP2D6 are also discussed. Although the candidate-gene approach has facilitated significant progress in our understanding of the genetic basis of glaucoma treatment response, most drug responses involve a large number of genes, each containing multiple polymorphisms. Genome-wide association studies may yield a more comprehensive set of polymorphisms associated with glaucoma outcomes. An understanding of the genetic mechanisms associated with variability in individual responses to topical β-blockers may advance individualized treatment at a lower cost

    Synovial joints: Mechanobiology and tissue engineering of articular cartilage and synovial fluid

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    This chapter provides an overview of the components of synovial joints including articular cartilage, synovium, and synovial fluid. Focus is placed on the biomechanical properties of these tissues and models of their behavior. Further insight is given into the influence of mechanical loading on the development of these joint components and changes during pathology. Finally, perspectives on engineering articular cartilage and synovial fluid are provided.\ud \ud Synovial joints allow for the articulation of long bones within a fluid-filled cavity. Articular cartilage (AC) is a connective tissue covering the ends of bones that functions as a load-bearing, low-friction, and wear-resistant surface to facilitate joint movement. Synovial fluid (SF) is the viscous liquid found inside synovial joints that functions as a biomechanical lubricant. The SF is encapsulated within the joint space by the synovium (SYN), a thin membrane-like tissue consisting of cells and extracellular matrix. The extracellular matrix of cartilage allows for load-bearing during joint motion, while the viscous and lubricating properties of SF reduce cartilage wear. The homeostasis of these tissues is dependent on mechanobiology – cell populations receiving mechanical cues to guide biosynthesis and thereby alter their microenvironment and tissue-scale mechanical properties. This chapter includes Tissue engineering (TE) and regenerative medicine (RM) approaches to the in vitro and in vivo development of articular cartilage and SF for the treatment and study of damaged synovial joints. First, the composition, structure, and function of cartilage and SF are discussed, followed by the mechanical properties of these tissues and the theoretical models that have been used to describe them. Next, the effects of mechanical stimuli on chondrocyte biosynthesis and pathological changes in SF composition are covered. Finally, advances in the fields of TE and RM applied to cartilaginous tissue and SF are reviewed, focusing on the mechanobiology of chondrocytes in Tissue engineered constructs

    Prediction of composition-dependent self-diffusion coefficients in binary liquid mixtures: The missing link for Darken-based models

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    Mutual diffusion coefficients can be successfully predicted with models based on the Darken equation. However, Darken-based models require composition-dependent self-diffusion coefficients which are rarely available. In this work, we present a predictive model for composition-dependent self-diffusion coefficients (also called tracer diffusion coefficients or intradiffusion coefficients) in nonideal binary liquid mixtures. The model is derived from molecular dynamics simulation data of Lennard-Jones systems. A strong correlation between nonideal diffusion effects and the thermodynamic factor is observed. We extend the model by McCarty and Mason (Phys. Fluids 1960, 3, 908-922) for ideal binary gas mixtures to predict the composition-dependent self-diffusion coefficients in nonideal binary liquid mixtures. Our new model is a function of the thermodynamic factor, the self-diffusion coefficients at infinite dilution, and the self-diffusion coefficients of the pure substances, which are readily available. We validate our model with experimental data of 9 systems. For both Lennard-Jones systems and experimental data, the accuracy of the predicted self-diffusion coefficients is improved by a factor of 2 compared to the correlation of McCarty and Mason. Thus, our new model significantly expands the practical applicability of Darken-based models for the prediction of mutual diffusion coefficients.Accepted Author Manuscript (the title slightly differs from the publishers version)Engineering Thermodynamic

    A narrative of the mission of the United Brethren among the Delaware and Mohegan Indians : from its commencement, in the year 1740, to the close of the year 1808 ; comprising all the remarkable incidents which took place at their missionary stations dur

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    Label of Bethlehem Book Bindery. Bookplate of Robert Heysham Sayre. [cy.1].; Stamp of American Antiquarian Society. Stamp of Lehigh University, with ""duplicate"" overstamp. [cy.1].; Inscription: Rev\u27d John Renatus Schmidt, Cherokee County, from his friend the Author, Bethm. 1st Nov. 1820. [cy.2].; Cd 108 cy. 2 lacks frontispiece.; Bookplate: Wm. G. Malin, no. 276 (Malin 276).; Inscription: To Bethlehem Library presented by the author, 1820. [CongLib 89].; Label of Congregation of the U.B. of the Borough of Bethlehem and its vicinity, no. 89.; Inscriptions: Geo. W. Huffnagle, with the regards of F. Gaunte, Sept. 1873. Elizabeth G. Cook presented by her father. Geo. W. Huffnagle. Franklin Gaunte, M.D., to Geo. Washington Huffnagle, Sept. 22 1873. [Ead 10 cy.2].; Inscription: Revd. Abraham Luckenbach from his friend John Heckewelder. Baltim. 12th March 1821. [Ead 10 cy.4].; Inscriptions: Ann G. Rice from Owen J. Rice. John H. Rice. [Ead 10 cy.3]
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