3,775 research outputs found

    Erratum: 3D bioprinted in vitro secondary hyperoxaluria model by mimicking intestinal-oxalatemalabsorption-related kidney stone disease (Applied Physics Reviews (2022) 9 (041408) DOI: 10.1063/5.0087345)

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    © 2023 Author(s).This article was originally published online on 21 November 2022 with an incorrect affiliation identifier for author Dong-Woo Cho. It is correct as it appears above. All online versions of this article were corrected on 23 November 2022. AIP Publishing apologizes for this error.11Nsciescopu

    Unimodality of Betti numbers for Hamiltonian circle actions with index-increasing moment Maps

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    The unimodality conjecture posed by Tolman in [L. Jeffrey, T. Holm, Y. Karshon, E. Lerman and E. Meinrenken, Moment maps in various geometries, http://www.birs.ca/workshops/2005/05w5072/report05w5072.pdf] states that if (M,ω) is a 2n-dimensional smooth compact symplectic manifold equipped with a Hamiltonian circle action with only isolated fixed points, then the sequence of Betti numbers {b0(M),b2(M),...,b2n(M)} is unimodal, i.e. bi(M) ≤ bi+2(M) for every i < n. Recently, the author and Kim [Y. Cho and M. Kim, Unimodality of the Betti numbers for Hamiltonian circle action with isolated fixed points, Math. Res. Lett. 21(4) (2014) 691-696] proved that the unimodality holds in eight-dimensional case by using equivariant cohomology theory. In this paper, we generalize the idea in [Y. Cho and M. Kim, Unimodality of the Betti numbers for Hamiltonian circle action with isolated fixed points, Math. Res. Lett. 21(4) (2014) 691-696] to an arbitrary dimensional case. We prove the conjecture in arbitrary dimension under the assumption that the moment map H : M → R is index-increasing, which means that ind(p) < ind(q) implies H(p) < H(q) for every pair of critical points p and q of H, where ind(p) is the Morse index of p with respect to H. © World Scientific Publishing Company1111sciescopu

    Systems biology for reverse aging

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    Cellular senescence is an irreversible and permanent cell cycle arrest in response to internal and external stresses. Its unresponsiveness to growth factor signals distinguishes it from a potentially reversible state, quiescence. Cellular senescence can inhibit tumor development by blocking proliferation of damaged cells, but as senescent cells become accumulated in a tissue, they can contribute to the promotion of agerelated diseases such as cancer by secreting inflammatory cytokines [1]. © 2021 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

    The antihypertensive effects of the Jamaican Cho-Cho (Sechium edule)

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    The experiments reported in this study constitute a preliminary investigation into the possible hypotensive effect of the Jamaican Cho-Cho (Sechium edule). Experiments were conducted in a random and blind fashion on two sub species of Sechium edule. Both the pulp and the peel were examined for hypotensive activity. Water-soluble extracts were prepared from these components of the fruit and injected into anaesthetised rats. Various cardiovascular parameters were measured including heart rate, mean arterial pressure (MAP) and several ECG intervals. We report that all extracts tested produced a fall in blood pressure with little change in ECG intervals. Extract B produced the least change in heart rate with a fall in MAP of approximately 23 mmHg. Changes in heart rate with all extracts appeared to be minimal as an ED25 value could only be determined for extract A, and ED10 values could not be evaluated for extracts C and D. The mechanism(s) by which these extracts produce their hypotensive effects could not be determined in these preliminary experiments. However, it appears not to involve direct effects on cardiac tissue. This conclusion is based on the finding that it took a minimum of 10 to 15 seconds for the hypotensive action to manifest post bolus. Future experiments will be aimed at delineating the mechanism(s) involved in decreasing MAP.Peer reviewedfinal article publishe

    Nota su Eschilo, Cho. 65

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    The author defends the reading ἄκραντος in the sense of “unfinished” in Aesch. Cho. 65

    Change of craniofacial deformity after sternocleidomastoid muscle release in pediatric patients with congenital muscular torticollis

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    Background: Craniofacial deformity is one of the main features of congenital muscular torticollis. The purposes of this study were to quantify craniofacial deformity and its postsurgical change in patients with congenital muscular torticollis and to analyze this change with reference to the age at surgery. Methods: Eighty patients with congenital muscular torticollis who had successful surgical release of the sternocleidomastoid muscle and had preoperative and follow-up cephalometric evaluation were studied. The craniofacial deformity was evaluated in two aspects: curvature and asymmetry. Postsurgical changes of craniofacial deformity were analyzed in all patients. Two groups of patients were identified: Group 1, which consisted of patients who had surgery before five years of age; and Group 2, which consisted of patients who had surgery at or after five years of age. Preoperative deformity parameters and the postsurgical changes were compared between Groups 1 and 2. Finally, postsurgical changes in the first and second year postoperatively were compared in forty-two patients for whom cephalometric radiographs were made at both the first and second-year follow-up visits. Results: All of the cephalometric parameters improved significantly after surgical release of the sternocleidomastoid muscle (p &lt;0.001). The preoperative craniofacial asymmetry parameters, such as transverse calvarial asymmetry and transverse skull-base asymmetry, were significantly more severe in Group 1 than in Group 2 (p = 0.018 in both), and these parameters improved significantly more in Group 1 than in Group 2 postoperatively (p = 0.029 and 0.003, respectively). No significant difference between Groups 1 and 2 was found in postsurgical changes of craniofacial curvature and mastoid-process length ratio. The improvements were significantly larger in the first year than they were in the second year in all parameters except mastoid-process length ratio. Conclusion: Cephalometry quantitatively showed improvement in the craniofacial deformity after surgical release of the sternocleidomastoid muscle. The results of this series were better when surgery was performed before the patient reached five years of age.More postsurgical change can be expected during the first year postoperatively than during the second year. Level of Evidence: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence. Copyright © 2012 by The Journal of Bone and Joint Surgery, Incorporated.N
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