891 research outputs found
Replication Data for: "Justice as Checks and Balances: Indigenous Claims in the Courts of Colonial Mexico"
No full textThe centralization of conflict resolution and the administration of justice, two crucial elements of state formation, are often ignored by the state-building literature. This article studies the monopolization of justice administration, using the historical example of the General Indian Court (GIC) of colonial Mexico. The author argues that this court's development and decision-making process can show us how the rule of law develops in highly authoritarian contexts. Centralized courts could be used strategically to solve an agency problem, limiting local elites' power and monitoring state agents. To curb these actors' power, the Spanish Crown allowed the indigenous population to raise claims and access property rights. But this access remained limited and subject to the Crown’s strategic considerations. The author’s theory predicts that a favorable ruling for the indigenous population was more likely in cases that threatened to increase the local elites’ power. This article shows the conditions under which the rule of law can emerge in a context where a powerful ruler is interested in imposing limits on local powers—and on their potential predation of the general population. It also highlights the endogenous factors behind the creation of colonial institutions and the importance of judicial systems in colonial governance
Influence of an empirical Geological Strength Index method for determining linear and nonlinear failure criteria
No full textThe construction of tunnels and underground galleries in mining has as fundamental input data the results of the failure criteria: traditionally Hoek–Brown and Mohr–Coulomb, to determine the failure envelopes that will allow the design of an economically exploitable mining system within viable safety frameworks that these criteria will guide. Therefore, the determination of rock mass resistance becomes fundamental and complex simultaneously due to the very nature of rock mass. Then, to identify a stressful state in which an excavation can be in conditions of stability it is necessary to have certain information both high in quality and economically valuable, which is not available in the early stages of the mining project. Thus, empirical methods and statistical relationships take notoriety, so this research evaluates the influence of an empirical method for the determination of the Geological Strength Index on the Mohr–Coulomb and Hoek–Brown failure criteria, with the benefit of estimating a stress field in which the excavation can self-sustain, evaluated in a first estimate in the pre-feasibility stage of the project, giving a guideline for design engineers. This research argues that the Geological Strength Index estimation method of Vivanco and Avendaño is recommended to estimate the Mohr–Coulomb failure criterion, but not the Hoek–Brown failure criterion
Motility and recovery of alpaca (Vicugna pacos) spermatozoa after centrifugation in a density gradient solution
No full textBackground: One of the factors limiting successful processing of alpaca (Vicugna pacos) semen is the viscosity of seminal plasma. The viscous nature of the collected ejaculate has hindered sperm cryopreservation as well as artificial insemination (AI) under field conditions. Aims: The objective of this investigation was to evaluate recovery, motility, and plasma membrane integrity of alpaca spermatozoa after centrifugation in one of two different solutions at one of three different combinations of speed and time. Methods: A total of 24 ejaculates was recovered from seven reproductively sound Huacaya males using a modified artificial vagina (AV) after training the animals for semen collection. A 2 × 3 factorial treatment arrangement was utilized for this study. Ejaculates were divided into fractions for centrifugation in one of two solutions (Tris extender or PureSperm®80 density gradient solution) at one of three combinations of speed and time (492 × g for 15 min, 1968 × g for 10 min, or 4448 × g for 7 min). The experiment was replicated eight times. Results: Analysis revealed that centrifugation at 4448 × g for 7 min in PureSperm®80 provided a high recovery rate of spermatozoa with the highest sperm motility and functional integrity of plasma membrane post-centrifugation. Conclusion: Results suggest that adoption of this procedure (centrifugation at 4448 × g for 7 min in PureSperm®80) in the initial processing of alpaca ejaculates may enhance subsequent ability to use semen for AI and other assisted reproductive biotechnologies in this speciesFil: Gómez Quispe, O. E.. Universidad Nacional Agraria La Molina; Perú. Universidad Nacional Micaela Bastidas de Apurímac; PerúFil: Gutiérrez Reynoso, G. A.. Universidad Nacional Agraria La Molina; PerúFil: Gallegos Cardenas, A.. Universidad Nacional Agraria La Molina; PerúFil: Fumuso, Fernanda Gabriela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Asparrin, M.. Fundo Mallkini de Michael & Cia S.A.; PerúFil: Asparrin Del Carpio, M.. Fundo Mallkini de Michael & Cia S.A.; PerúFil: Jara, C. W.. Fundo Mallkini de Michael & Cia S.A.; PerúFil: Ponce, D.. Vivanco International SAC; PerúFil: Miguel, M.. Vivanco International SAC; PerúFil: Youngs, C. R.. Iowa State University; Estados UnidosFil: Vivanco, H. W.. Vivanco International SAC; Per
Figure 5—source data 1. Contains source data for Figure 5.
No full textThe serine–threonine kinase AKT regulates proliferation and survival by phosphorylating a network of protein substrates. In this study, we describe a kinase-independent function of AKT. In cancer cells harboring gain-of-function alterations in MET, HER2, or Phosphatidyl-Inositol-3-Kinase (PI3K), catalytically inactive AKT (K179M) protected from drug induced cell death in a PH-domain dependent manner. An AKT kinase domain mutant found in human melanoma (G161V) lacked enzymatic activity in vitro and in AKT1/AKT2 double knockout cells, but promoted growth factor independent survival of primary human melanocytes. ATP-competitive AKT inhibitors failed to block the kinase-independent function of AKT, a liability that limits their effectiveness compared to allosteric AKT inhibitors. Our results broaden the current view of AKT function and have important implications for the development of AKT inhibitors for cancer.National Institutes of Health (1R01NS080944–01, U54CA143798, F32 GM096558), the James S McDonnell Foundation, and National Brain Tumor Society Defeat GBM initiativ
Análisis del humor en las obras de María Fernanda Heredia: Amigo se escribe con H y Foto Estudio Corazón
No full textEl análisis del humor en las obras Amigo se escribe con H y Foto Estudio Corazón de María Fernanda Heredia, permite adentrarnos en el maravilloso mundo de la narrativa literaria. Poder relacionar el recurso humorístico con el estilo de escritura de esta talentosa literata, conduce a conocer dos valores fundamentales en la vida de los niños y jóvenes, como es el amor y la amistad, temas característicos en las obras de esta autora, ya que como ella manifiesta “no concibe la vida sin amor y sin humor” Con una gran habilidad literaria y un exquisito humor en la redacción, la autora encarna en cada uno de los personajes ficcionales, aspectos y cualidades tan humanas y reales, logrando que los lectores se sientan identificados con ellos. La lectura de sus obras, a más de producir goce y disfrute, conduce a la reflexión, porque la autora ha logrado plasmar en sus obras temas de la vida real; y, aunque estos a veces suelen ser duros y conflictivos, una dosis de humor los suaviza, haciendo que su lectura sea más divertida y amena.Analysis of humor in the works "Friend writes with H" and "Heart Photo studio" Maria Fernanda Heredia, can get into the wonderful world of literary narrative. To relate resource humorous writing style of this talented literate, it leads to meet two fundamental values in the lives of children and youth, such as love and mistad, characteristic themes in the works of the author, because as she says "can not conceive of life without humor
and without love" With great literary skill and exquisite humor in the writing, the author embodied in each of
fictional characters, aspects and qualities as human and real, making readers feel identified with them. Reading his works, apart from producing enjoyment leads to reflection, because the author has managed to capture in his works real life issues; and although these sometimes harsh and often conflicting, a dose of humor smooths, making reading more fun and enjoyable
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
No full textTransport of macromolecules through the nuclear pore by importins and exportins plays a critical role in the spatial regulation of protein activity. How cancer cells co-opt this process to promote tumorigenesis remains unclear. The epidermal growth factor receptor (EGFR) plays a critical role in normal development and in human cancer. Here we describe a mechanism of EGFR regulation through the importin β family member RAN-binding protein 6 (RanBP6), a protein of hitherto unknown functions. We show that RanBP6 silencing impairs nuclear translocation of signal transducer and activator of transcription 3 (STAT3), reduces STAT3 binding to the EGFR promoter, results in transcriptional derepression of EGFR, and increased EGFR pathway output. Focal deletions of the RanBP6 locus on chromosome 9p were found in a subset of glioblastoma (GBM) and silencing of RanBP6 promoted glioma growth in vivo. Our results provide an example of EGFR deregulation in cancer through silencing of components of the nuclear import pathway.This research was supported by the National Brain Tumor Society (I.K.M.), the National Institutes of Health grants 1R01NS080944-01 (I.K.M.), 1 R35 NS105109 01 (I.K.M.), and P30CA008748 (MSKCC Core Grant), the Geoffrey Beene Cancer Research Foundation (I.K.M.), the Cycle of Survival (I.K.M.), and the Seve Ballesteros Foundation (M.S.). B.O. was supported by an American–Italian Cancer Foundation fellowship and a MSKCC Brain Tumor Center grant. W.-Y.H. is the recipient of a FY15 Horizon Award from the U.S. Department of Defense (W81XWH-15-PRCRP-HA). A.C.-G. is the recipient of the Severo-Ochoa PhD fellowship. Further support was provided by the Sontag Foundation (B.S.T.). We thank all members of the Mellinghoff laboratory for helpful suggestions. We thank Dr. Fiona Ginty (Diagnostic Imaging and Biomedical Technologies, GE Global Research Center, Niskayuna, New York, USA) for assistance with multiplexed immunofluorescence. We thank A.J. Schuhmacher and C.S. Clemente-Troncone for assistance with the in vivo experiments, M. Kaufmann for assistance in the luciferase assays and N. Yannuzzi for assistance in cloning.S
Una nueva versión del mito de Inkarri
No full textThe author, in a paper presented in the VI National Folklore Congress of Huaraz, Ancash, in 1983, exposes the myth that we reproduce in this article.El autor en una ponencia sustentada en el VI Congreso Nacional de Folklore de Huaraz, Ancash, en 1983, presenta el mito que en este artículo reproducimos
La cultura árabe y su historia en Ibn Jaldún. Comentario de: Yamarilis Quevedo Parra
No full textThe Arab Culture and Its History in Ibn Khaldun, by Luis Vivanco Saavedra, is a comprehensive study of Islamic historiography from its origins to the intellectual contributions of Abderrahman Ibn Khaldun. Structured in five chapters and two appendices, Vivanco intertwines historical research with philosophical reflections on knowledge, language, and collective memory. The book highlights key historiographical genres such as biography, chronicles, travel literature, and theoretical treatises. Special focus is given to Ibn Khaldun’s Muqaddimah, where he proposes a “new science” to understand the dynamics of societies. The author offers a critical evaluation of Ibn Khaldun’s seemingly pessimistic view of history while acknowledging the depth and relevance of his thought. This work stands as both a scholarly contribution and a useful reference for those interested in the foundations and evolution of historical thinking in Islamic culture.La cultura árabe y su historia en Ibn Jaldún, de Luis Vivanco Saavedra, es una obra que realiza un recorrido exhaustivo por la historiografía islámica desde sus orígenes hasta la figura de Abderrahmán Ibn Jaldún. A través de cinco capítulos y dos apéndices, Vivanco combina el análisis histórico con profundas reflexiones filosóficas sobre el conocimiento, el lenguaje y la memoria colectiva. El texto destaca la importancia de géneros como la biografía, la crónica, los viajes y los tratados de metodología histórica. Especial atención se dedica a la obra Muqaddimah (Prolegómenos), en la cual Ibn Jaldún propone una "nueva ciencia" para comprender el devenir social. El autor evalúa críticamente la visión pesimista del historiador árabe, reconociendo el valor y la vigencia de sus aportes. Esta obra se presenta como una herramienta útil tanto para especialistas como para lectores interesados en los fundamentos y evolución del pensamiento histórico islámico
El lugar de la lluvia
No full textEsta miniguía se basa en textos de Hernán Cortés, Bernal Díaz del Castillo, Alfonso Medellín Zenil, José Luis Melgarejo Vivanco, Ramón Arellanos M. y Luis Sánchez y otros autores.Desde tiempos precerámicos existieron grupos humanos en Nuevo, Roca Escondida y otros lugares de la f aja costera central del golfo; se sabe de su desarrollo porque se localizó cerámica similar a la de Tehuacán, considerada una de las más antiguas de México. En el Preclásico Medio esos hombres experimentaron el influjo de la cultura olmeca lo que produjo los elementos característicos del grupo totonaca. El territorio totonaca cubrió la serranía poblana y las llanuras costeras. Sus "fronteras" variaron con el tiempo de norte a sur, desde los ríos Cazones hasta el Papaloapan</p
La casa de moneda de Zacatecas 1876-1895: Un caso de empresa regional
No full textTesis para obtener el grado de Licenciatura en Etnohistori
- …
